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Dr. Rick Barnett, PsyD ❄️✨🔥 Profile picture
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3 Jan, 5 tweets, 2 min read
For those interested in #cannabis #pharmacology review: ncbi.nlm.nih.gov/pmc/articles/P… “in this short review we tried to shed light on the potential drug interactions of medicinal cannabis” 1/4 @division_55
“potential outcome of a drug interaction can be additive (1 + 1 = 2), synergistic (1 + 1 > 2), or antagonistic (1 + 1 < 2). Therefore, a drug interaction may lead to an enhanced drug response or modified or unexpected adverse reactions” 2/4
“Cannabis has been used in various forms as crude extracts or purified ingredients (different THC/cannabinoids ratios); therefore, drug interactions caused by cannabis depend not only on drugs involved but also chemical components/profiles of the cannabis preparations used” 3/4
“systematic review by Stout & Cimino (2014) showed P450 involved in metabolizing several exogenous cannabinoids, i.e. tetrahydrocannabinol (THC; CYP2C9, 3A4), cannabidiol (CBD; CYPs 2C19, 3A4) cannabinol (CBN; CYPs 2C9, 3A4), supported by data on THC and CBD metabolism” 4/4
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More from @drrickbarnett

Dr. Rick Barnett, PsyD ❄️✨🔥 Profile picture
31 Dec 20
psychedelicinsights.com/blog/
The Top 10 Psilocybin Research Papers of 2020
- FS Barrett, MK Doss, ND Sepeda, et al. – Emotions and brain function are altered up to one month after a single high dose of psilocybin. @FredBarrettPhD 1/10
SB Goldberg, BT Pace, CR Nicholas, et al. – The experimental effects of psilocybin on symptoms of anxiety and depression: A meta-analysis. “meta-analysis of studies using psilocybin along with behavioral interventions to treat elevated symptoms of anxiety and depression.” 2/10
GI Agin-Liebes, T Malone, MM Yalch, et al. – Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer. “follow-up approx 3.2 and 4.5 years later, w/ 15 of the 16 participants still alive” 3/10
Read 11 tweets
Dr. Rick Barnett, PsyD ❄️✨🔥 Profile picture
29 Dec 20
Fascinating @JAMANetworkOpen article on #schizophrenia treatments .. limits of #pharmacotherapy and benefits of added #psychosocial treatments. Here’s a snippet with eye towards how this relates to treating other mental health conditions. 1/4 @division_55
jamanetwork.com/journals/jama/…
“Among responders (to meds), some are able to function independently, others remain disabled despite control of their psychotic symptoms...residual disability attributed to negative symptoms and cognitive deficits, which are less responsive than psychosis to drug treatments.” 2/4
“persistence of disability and ↘️ quality of life, poor medication adherence necessitated delivery of evidence-based psychosocial services, including CBT; family psychoeducation; social skills training; assertive community treatment; and assistance w/work, education, housing” 3/4
Read 4 tweets
Dr. Rick Barnett, PsyD ❄️✨🔥 Profile picture
16 Dec 20
I got a degree in Clinical Psychopharmacology after getting my license to practice as a Doctor of Psychology because I started working w/older adults who struggled emotionally AND were prescribed a TON of meds. Something wasn’t right. I had to know more. @division_55 1/7
Not only did i learn basic clinical medicine, pathophysiology, review of systems, lab workups, etc.. but also learned about effects of drug-drug, drug-disease interactions on mood, mind, behaviors, and stress. One tool i still find useful is the #BeersCriteria (not etoh..lol) 2/7
Here’s a link to 2020 Updated from 2015 guidelines from @aafp aafp.org/afp/2020/0101/… Inappropriate Medication Use in Older Adults. If you have an older adult in your life, check their med-list. You’ll be surprised. Or maybe not. Here are “key points of practice”: 3/7
Read 7 tweets
Dr. Rick Barnett, PsyD ❄️✨🔥 Profile picture
15 Dec 20
Gonna highlight some of this article in a thread. Thank you @headdock et al. This is a must read for those interested in drug death crisis. #polypharmacy and #polydrug is the problem #notjustopioids
dovepress.com/the-polysubsta… @apadivision50 @division_55 @APADiv28
1/5
“It is time to take the blinders off. It is time for everyone – clinicians, legislators, insurers, media, family members, and all others, including the general public – to recognize the complexities of the issues surrounding the crisis of polysubstance overdose deaths.” 2/5
“The terms “opioid-induced respiratory depression” and “opioid-overdose death” are outdated, as they fail to reflect current realities and only further continue the errant notion of simplicity. They should be abandoned for the more accurate and clinically-helpful terms” like..3/5
Read 5 tweets
Dr. Rick Barnett, PsyD ❄️✨🔥 Profile picture
26 Nov 20
#gratitude thread 1/12
“Appreciation is a wonderful thing. It makes what is excellent in others belong to us as well.” Voltaire
#grateful for classics @CIIS_SF
#gratitude thread 2/12
“When eating fruit, remember the one who planted the tree.” Vietnamese Proverb @BreneBrown
@grateful for cultures
#gratitude thread 3/12
“Got no checkbooks, got no banks, still I’d like to express my thanks. I got the sun in the morning and the moon at night.” Irving Berlin @PolarisInsight
#grateful for music
Read 13 tweets
Dr. Rick Barnett, PsyD ❄️✨🔥 Profile picture
27 Aug 20
“Of potential harms of getting distracted by a more progressive model of mental healthcare by polarized ideas is that it could prevent people from seeking care that they may want, or invalidate experiences of people who have been helped by psychiatry” vice.com/en_us/article/… 1/4
@jonathanstea @JonathanShedler @AllenFrancesMD @VICENews “By claiming that mental illness doesn't exist at all, anti-psychiatry could also lead us astray from much-needed reform within psychiatry, precisely because it seeks not to improve psychiatry, but to tear it down.” 2/4
“There are useful discussions and summaries on Mad in America. Importantly, there are also real experiences and trauma behind many of the posts that discuss the harms patients suffer from psychiatry.” @Mad_In_America @sandysteingard 3/4
Read 5 tweets

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