Ireland 🇮🇪 & N. Ireland are in a serious #COVID19 crisis. Cases surging past 🇬🇧.
➡️Ireland also has increased presence of the B117 variant—now found in **25%** of cases that underwent further testing in week to Jan. 3, up from just 9% two weeks earlier. reuters.com/article/us-hea…
2) This dooms day B117 variant taking over scenario with sharp vertical increase is exactly the most feared scenario Denmark CDC — Denmark 🇩🇰 is also seeing sharp rise. And they fear they will soon lose control. See thread 🧵
3) To be clear—even if we hold the virus in check with a minimum R=0.96... by the time the new virus variant takes hold, it will be woefully insufficient, since the B117 strain is 40-80% more infectious (multiply current R*1.4 or *1.8). Other experts agree....
4) Notably, the virus is such a beast—suppose we have 1000 cases/day now... with an R=0.86 we could reduce it to 500/day in 2 weeks.
➡️But w/ added contagiousness of B117 variant that has ~60% higher R, in 2 weeks, we’d have 3000 new cases/day instead—3x!
6) Now how does the new B117 variant change public health measures? What used to work for Australia and Canada will no longer work anymore. Only aggressive New Zealand and Austria 1st wave restrictions would now be able to stop the more transmissible B117 strain.
7) Now suppose we want to chase #ZeroCovid with Austria’s spring 2020-level aggressive strategy—what would used to take just 45 days to reach zero #COVID19 cases with old variants suppressed to R=0.54, now would require *190 days* w/ B117 strain burning at R=0.864 ➡️4x longer!
8) To be clear, the rise in Ireland 🇮🇪 also coincided with the loosening of restrictions. So some of it due to that, but it may have synergistically combined with the rise of the more infectious B117 variant.
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SICKENING—Rep. Bonnie Watson Coleman, a 75-year-old cancer survivor, has tested #COVID19 positive after taking shelter in a room, where many GOP refused to wear masks. She believes she contracted the virus while in protected isolation room. So avoidable. washingtonpost.com/politics/mob-a…
2) We knew this could happen. Yesterday, Congress’s attending physician sent out a warning someone had Covid in the isolation room already.
⚠️HELP FIND WHO MUTILATED A MANATEE: U.S. Fish and Wildlife Service is investigating who carved the word "Trump" on a Florida manatee. USFWS is looking for any information: cal Florida Fish and Wildlife Conservation hotline at 888-404-3922. chronicleonline.com/news/local/fed…
2) Maybe someone bragged on Parler and will get nailed for it...
Oh shit—British 🇬🇧 traveler visits Japan 🇯🇵 and violates quarantine upon arrival—decides to go out to restaurants instead. Infects 2 other people with #COVID19 while going out. And guess which damn #SARSCoV2 strain it was? ➡️ the #B117 variant from UK. 🤦🏻♂️ nikkei.com/article/DGXZQO…
2) Kudos to fast action of Japanese epidemiologists. Japan 🇯🇵 also helped Brazil 🇧🇷 identify the new worrisome B11248 variant in 4 passengers flying from Brazil. Why is it worrisome? Because it has the bad E484K variant. #COVID19
BREAKING—A new #SARSCoV2 variant (aka B.1.1.248) identified by Japan 🇯🇵 in ✈️pax from Brazil 🇧🇷. This new one has both the more infectious N501Y mutation (not affect vaccine), as well as the disruptive E484K mutation that escapes neutralizing antibodies.🧵 bloomberg.com/news/articles/…
2) Why are we so worried about this one? Because like the SA B1351 variant, this new one also has the E484K mutation. In a recent study by @jbloom_lab, E484 mutation (inside the #SARSCoV2’s spike’s critical receptor binding domain) seemed to escape neutralizing antibodies—bad.
3) More on the E484K mutation. Escaping neutralizing antibodies could mean some convalescent plasma, some antibody drugs, and maybe even vaccines could be disrupted a little. But need more studies to prove it
BREAKING—Ireland 🇮🇪 says the B117 #SARSCoV2 variant now accounts for 45% of all 92 samples sequences. Up from 25% last week, and up from 9% 2 weeks before that. Ireland also loosens restrictions & cases up 10x from last month & seeing surge surpassing even England 🏴. #COVID19