@sash_andy@samwoolfe@lisa63artist@jonathanstea@bmj_latest@hrw@C4Dispatches@gmcuk Fact is, testimony of injured patients on social media shows adverse effects are real, not just tiny print in gray ink on a pill packet insert. Adverse effects are real, & they may happen to you. If prescribers find this complicates their sales pitch, maybe vary the pitch? /12
@awaisaftab Hello, Awais. I will attempt to answer your excellent questions. @HengartnerMP may wish to add his perspective as well. /1
@awaisaftab@HengartnerMP Re your #2: This was a retrospective study. Duration & symptom criteria from Chouinard & Chouinard, 2015 were used in selecting subject population. Other of C&C's criteria (C) were addressed in analysis & discussion. The paper only weakly corroborates C&C's criteria (C). /2
@awaisaftab@HengartnerMP "Greater severity of illness": We relied upon subjects reporting symptoms were qualitatively different than prior to treatment. It is impossible to quantify "greater severity", the symptoms being so various & most unlike original condition. They certainly were distressing. /3
Let's unpack why @psychunseen publishes posts such as this one, seeking to delegitimize patient movements he's observed on Twitter. He's been doing this for more than a year. /1
First, everyone should be aware @psychunseen is a #psychiatrist who treats inpatients for the Veterans Administration in Los Angeles.
The target of the tweet is the "drop the disorder" people, but, ill-advisedly, he swipes at chronic Lyme & CFS patients as well. /2
@psychunseen has been working on this thesis for a long time: That patient campaigns on social media are driven by pathological psychiatric conditions, not the desire of patients for better care from doctors. /3
@DepressionLab@tkaiser_science@Martin_Ploederl@HengartnerMP@CVolkmannMD@f_hieronymus So search for the reason "antidepressants" are "antidepressant" is doomed. Ultimately, you'd find any psychotropic causes neurobiological adaptation, that's the definition of a psychotropic, & some humans will subjectively interpret the effect as antidepressant. Others won't.
Lack of physician confidence in tapering plays a large role. Their patients don't trust their knowledge, either, & rightly so. This is a subject nobody wants to unpack.
@DrFulli@lapsyrevoltee I do agree, Dr. Fulli. Response to the drug most certainly is not a diagnosis, & those physicians who conclude an adverse reaction to an #antidepressant is diagnostic of bipolar disorder not only have poor pharmacology knowledge but poor logical skills as well. /1
Conversely, any psychotropic might relieve "depression" in someone, eg. amphetamines or opiates. This is another law of psychotropics. /2
@DrFulli@lapsyrevoltee For what it's worth, I have a collection of case studies where people had immediate severe adverse reactions to #antidepressants & even though they quit within a handful of doses, suffered symptoms identical to post-acute withdrawal syndrome #PAWS for months or years. /3
"Professionalism in any field requires keeping pace with change, & nowhere is it more true than medicine....valid knowledge may come from the patient as well as from clinician resources: a sociological change driven by technological change." #psychiatry /1 journals.sagepub.com/doi/10.1177/00…
"Case after case is presented showing that patients today have generated undeniable value, violating the expectations and assumed best practices of the old model." doi.org/10.1177/009121… /2
"standards of professionalism & appropriate care must be updated, lest we fail to achieve best possible care....new standard must be to teach clinicians to recognize, welcome, & work with empowered #epatients in the new model of participatory medicine." doi.org/10.1177/009121…