Heading out to vaccinate “people” in Rhode Island today
It may not be a big stadium, it may only be a VFW, it may only be 450 little shots, but these “people” are somebody’s world ... let’s give their community a big shot in the arm #cmgsays
The COVID vaccination is an intramuscular injection. It is NOT a subcutaneous injection. To give a #COVID19 IM injection DO NOT pinch the skin & Do NOT angle the needle at 45 degrees. This will cause the injection to go into the subcutaneous fat rather than the deltoid muscle.
To give an IM injection, aim the needle perpendicular to or at 90 degrees to the skin. The CDC does not recommend that you draw back on the needle (there are no big vessels in the deltoid muscle),
You don't want the vaccine to leak back out of the muscle through the needle track.
So use the Z technique where you pull the skin sideways with the hand you are not injecting with so that when you let go, there is not a straight line from the muscle to leak out of the body.
Why give vaccines into the muscle (IM) instead of under the skin (sub q)?
The muscle has more blood vessels & the vaccine gets absorbed into the body better & you are more likely to get an immune response compared with the fatty tissue under the skin. ncbi.nlm.nih.gov/pmc/articles/P…
There is a temptation to want to massage or rub the vaccinate area after vaccination.
Try to avoid this as it may again squeeze some of the vaccine out of the muscle where all the good blood flow is into the fatty tissue under the skin which does not have as good of blood flow.
In summary:
Do Pull the skin sideways
Don't Pinch the skin
Don't Massage the skin
You have now been "armed" for your injection and don't be shy!
If you see someone pinching the skin and injecting at 45 degrees like I have seen on TV, speak up!
Tell them to not pinch and to go in at 90 degrees!
Use the short needle on the left for smaller people
Use the longer needle on right if if looks like it is a long way to the muscle
"They require twice as much attention as a typical intensive-care unit patient, for three times the normal length of stay. “It was doable over the summer, but now it’s just too much,”
“Last Monday we had 25 patients waiting in the emergency department. They had been admitted but there was no one to take care of them.” I asked her how much slack the system has left. “There is none,” she said.
The analysis evaluated 94 confirmed Covid-19 infections among 43,538 participants.
The vaccine efficacy rate was above 90% at seven days after the second dose.
This is far above the 50% rate required by the FDA.
This is preliminary data.
The companies said they plan to submit the data to the FDA for emergency use authorization as soon as they have two months of data, which is currently on track for the third week of November.
Breaking: Astra Zeneca halts vaccine trial for safety review due to a serious adverse event. Anonymous source says volunteer developed transverse myelitis, an inflammatory syndrome that affects the spinal cord and is often sparked by viral infection. nytimes.com/2020/09/08/wor…
The Duration of the safety review is unknown.
The Relationship of the case of transverse myelitis to the vaccine is unknown.
AZ’s vaccine uses a chimpanzee adenovirus to carry the #COVID19 genes into human cells. Although adenovirus are generally harmless,
they “can sometimes trigger their own immune responses, which could harm the patient without generating the intended form of protection.”
There are tears and holes in the canvas and missing paint.
Art restoration brings together my love of restoring things to vitality, painting, science and woodworking / cabinetry making.
I started by patching the tears & holes by using archival acid free glue to add new linen canvas to the back of the painting.
You can see how deep the holes are. Lots of layers of gesso, hide glue, & paint had been used 300 years ago. I have filled in the holes with Gesso, a kind of stretchable plaster. I added Lots of small layers until the gesso was just a little higher than the surface of painting
1. The follow-up is 2 years after the 2cd dose in the Moderna trial. You cannot enroll if you plan to get another vaccine.
If I get randomized to placebo, & the drug gets approved, will the blind be broken at that time & will I be told I got placebo?
2. Is it ethical to have 15,000 people who were enrolled but received placebo, and don't know that they were randomized to inactive placebo in the context of this and other vaccines being approved?
If they knew, they could elect to get an active vaccine.
3. You could argue that the blind should be maintained to collect 2 year safety & effectiveness data. This is a valid argument to look at long term effects.
But the placebo patients are not being vaccinated, and there is an approved, effective vaccine available.
Is this fair?