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Aleena Banerji, MD

26 Jan, 4 tweets, 6 min read

@MGHAllergy

1/ @MGHAllergy @BWHAllergy @vumc_cdsi_rsch #vaccine and #drugallergy experts provide a clear and concise approach to safely evaluate those with a history of #anaphylaxis and anyone with an #allergicreaction reaction to the first dose of @Pfizer or @Moderna #CovidVaccine.

@JACIInPractice

2/ See our updated manuscript @JACIInPractice that includes information on #skintesting using non-irritating skin test concentrations to #PEG and #polysorbate and when to consider #skintesting jaci-inpractice.org/action/showPdf…

3/ The potential life-saving benefit of vaccination makes it essential that we carefully evaluate every possible #allergicreaction to prevent denying access to the vaccine unnecessarily. Our knowledge is rapidly evolving and future recommendations may change with more data.

@KimberlyBlumen1

4/ Special thank you to my co-authors who supported this effort and helped get this across the finish line (a second time) despite quite a few hurdles. What a marathon! @KimberlyBlumen1 @AnnaWolfsonMD @rebeccasaff @PaigeWickner @LaceyRobinsonMD @AidanLongMD

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Aleena Banerji, MD

@AleenaBanerjiMD

10 Jan

@US_HAEA

1/ New guidelines from the @US_HAEA Advisory Board are now available @JACIInPractice. We provide an update on classification, diagnosis, on-demand/prophylactic tx with special considerations for women/children along with guidance on development of a comprehensive management plan.

2/#HAE can be broadly divided into #HAE due to C1INH deficiency (type 1 and type 2) and HAE with normal labs (4 mutations now identified - factor XII, plasminogen,
angiopoetin-1, and kininogen). Early diagnosis is critical. If you suspect send C4, C1INH level and function.

3/All patients with #HAE must have ready access to effective on-demand medication and trained in self-administration. Encourage on-demand treatment of all #HAE attacks. Four FDA approved on-demand treatments available (ecallantide, icatibant, pdC1INH, or rhC1INH)

Read 5 tweets

Aleena Banerji, MD

@AleenaBanerjiMD

1 Jan

1/ As #Allergists, built upon the recommendations of U.S. regulatory agencies, we can provide clear steps to the medical community on how to safely administer both doses of the #COVID vaccine in individuals with #allergic histories. #AIMedEd jaci-inpractice.org/article/S2213-…

2/ Neither the #PfizerBioNTech nor #Moderna #COVID19 mRNA vaccines are formulated with any food, drugs, or latex, but both contain the excipient #PEG. However, to date, confirmation that PEG is the cause of reactions to #CovidVaccines is lacking.

3/ Complement-activation-related pseudoallergy, vasovagal reactions (well known cause of hypotension), anxiety symptoms or vocal cord dysfunction can mimic symptoms of severe allergic reactions. Serum #tryptase, complement studies, and #PEG antibodies may be helpful.

Read 6 tweets

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