Thread by @EricTopol

First evidence in man that there is #SARSCoV2 vaccine resistance to B.1.351 ("South African") variant
nytimes.com/2021/01/28/hea… Not good to see
@Novavax by @katie_thomas @carlzimmer @SharonLNYT

South African trial of >4,000 participants
49.4% efficacy
Of 44 participants with infection events, sequencing of their virus showed B.1.351 in 25 samples

@novavax slide via @kakape shows differences in participants with or without HIV and different denominator for sequencing than above.
--25/27 infection events were B.1.351

To emphasize, there were mixed data regarding immune escape for B.1.351, and vaccine "resistance" is not all or none. That there is relative (some) loss of vaccine protection reinforces the in vitro studies suggesting E484K and other mutation's escape potential