Yes they should. Dexamethasone, Bromhexine, Melatonine and a few others like Colchine had in-silico interesting results as early as 1st of March. With the exception of dexa still waiting for the large scale RCTs.
https://twitter.com/gummibear737/status/1355654603703021570
Haven't said this publicly before but early on with a group of MDs, biotech and others researchers we built a protocol coupling statistical exploration techniques from AI with low toxicity drugs for profilaxis use. Apparently it was too innovative and rejected by our government.
With the exception of dexamethasone, all the others were already identified to be used in the early treatment of at risk with high probability contract protocol. Probably ivermectin that appeared later would have made the cut too, given the profile.
It is still alien to me why in cases like a pandemic the medical professionals don't embrace nonparametric statistics in order to perform fast and efficient discovery of treatment. Instead they go with the standard parametric n-arm trials which are very inneficient.
Instead a RCT using multi-armed bandit can hone in into a treatment pretty fast (if any one -or several- of them is good) using exploration techniques widely used in AI. Funny thing, the mathematics required are more than 40 years old.
But to add insult to injury, every day that passes many of our hypothesis like for instance that there may have been some casuality to the correlation of mortality and Melatonine behavior in age and sex could have been investigated early on. scitechdaily.com/melatonin-prod…
Should have read "causality". Sorry to be blunt, but this is on the medical professionals (not all of them but many didn't know best either). It's not that the tools didn't exist, it's that they don't understand them. And lets not start with how epidemiology is doing.
How many more confirmations they need to see that ours is probably the most accurate and most importantly highly predictive model out there? The waves, the 'with' the virus, asymptomatic, presymptomatic and short infectious period. What else do they need to take us seriously?
Rant over. Thanks but I need to say it. This is beyond infuriating.
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