COVAX facility just published a forecast of what country will receive how much of what #covid19 vaccine in the first half of this year.
Lots of caveats of course. This is mostly AZ vaccine, which does not have emergency use listing yet, for instance.
gavi.org/sites/default/…
Big picture:
Countries can expect to receive vaccine to cover on average 3,3% of their population in first half of 2021, "enough to protect the most vulnerable groups such as health care workers”.
Here is “A” to give you an idea (SFP are self financing countries)
Most vaccine here is AstraZeneca’s:
240 million doses of AZ vaccine licensed to Serum Institute of India (SII)
96 million doses directly from AZ (this was supposed to be 153 million, but some shipments delayed to Q3)
Also 1,2 million doses of Pfizer vaccine
Because of low number, says @GaviSeth, "as well as the complexity of the ultra cold chain equipment that is required to deploy, we've had to use a very specific methodology for determining distribution of these first vaccines."
@GaviSeth Allocation of the 1,2 million Pfizer doses took into account country readiness, but also prioritised countries that had not started any immunisations yet and countries where health care workers were exposed to high transmission, says @ann_lindstrand.
@GaviSeth @ann_lindstrand "Many of these doses will go to health workers in urban areas, who are at highest risk of exposure to #COVID19 infections”, says @unicefchief. Says work has begun for instance in Bosnia-Herzegovina, which will early recipient. First 2 of 8 refrigerators from Unicef have arrived.
@GaviSeth @ann_lindstrand @unicefchief "We are on the path to really start balancing out a global map, which so far has shown how many lower income countries are yet to start vaccinating a single person, while other, wealthier countries go ahead towards mass vaccination”, says @frekris of @CEPIvaccines.
@GaviSeth @ann_lindstrand @unicefchief @frekris @CEPIvaccines “We certainly still have a long way to go”, says @frekris. “We cannot afford to lose sight of the fact that this pandemic cannot be ended unless safe and effective vaccines are made made available to all."
@GaviSeth @ann_lindstrand @unicefchief @frekris @CEPIvaccines Immunizations should start end of February or beginning of March, says @ann_lindstrand. “We're not saying a set date because there are certain caveats that we really need to set, and get ready”, mentions regulatory authorisation, indemnification and liability, logistics.
@GaviSeth @ann_lindstrand @unicefchief @frekris @CEPIvaccines New variants need to be watched, says Lindstrand. “The most important though is that we use fast the vaccines we now have, and get them, distributed to all of the populations that need them around the world."
@GaviSeth @ann_lindstrand @unicefchief @frekris @CEPIvaccines "CEPI is working with all of the manufacturers now to ask the question: How might we adapt vaccines? Do we need to think about booster doses or additional antigens or other ways to work?”, says @GaviSeth.
@GaviSeth @ann_lindstrand @unicefchief @frekris @CEPIvaccines “Of course, we would like more Biontech vaccines in the first and second quarter”, says @GaviSeth. "That is what we were offered given the demand and supply that was there.”
@GaviSeth @ann_lindstrand @unicefchief @frekris @CEPIvaccines “We encourage every manufacturer to make the largest number of doses they can available early, so that we can make sure that we get equitable distribution going, so that with that we can then help control this pandemic as quickly as possible”, says @GaviSeth.
@GaviSeth @ann_lindstrand @unicefchief @frekris @CEPIvaccines Variants open a plethora of R&D questions, says @frekris. “We're working very closely with all the manufacturers in terms of being as ready as possible to do what's called strain variation, so small tweaks to the vaccine so that they can actually work with new strains."
@GaviSeth @ann_lindstrand @unicefchief @frekris @CEPIvaccines I asked about the impact of bilateral deals.
One purpose of COVAX was “to keep the number of bilateral deals down as much as possible”, says @GaviSeth. “For a while that happened but there's most recently been a lot of deals being made."
@GaviSeth @ann_lindstrand @unicefchief @frekris @CEPIvaccines I assume Germany and other EU countries that have bilateral deals in place decided to not take any doses through COVAX because of this. “Of course it helps because that means there are more doses available for others”, says @GaviSeth.
@GaviSeth @ann_lindstrand @unicefchief @frekris @CEPIvaccines COVAX also hopes to get donations from some of these countries, say @GaviSeth. “Our hope is that ultimately countries will make their vaccines available if they have access doses or even options to the COVAX facility, so we can increase the speed of rollout."

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More from @kakape

4 Feb
I‘m struck that it still hasn’t sunk in how much #b117 may change the course of this pandemic.

The initial shock about it being more transmissible seems to have worn off. But we are barely beginning to see its real-world impact.

A story: sciencemag.org/news/2021/02/d…
And a thread
After #b117 was identified in England and seemed to be taking off there, many people like me started looking at Denmark for clues.
Why Denmark? It sequences a lot! Here is a graph from @ECDC_EU from late December showing EU sequencing (look at B and note that it’s a log-scale): Image
@ECDC_EU Denmark has actually massively scaled-up its sequencing since then.
@MadsAlbertsen85 and his team, who have basically been doing all the sequencing for the whole country, are now getting close to 70% which is about as much as is possible (30% have low virus concentrations).
Read 15 tweets
2 Feb
Interim results from Russia’s #covid19 vaccine Sputnik V are out and looking good.

Vaccine efficacy was 91.6%

And once again an even stronger signal on moderate/severe cases:
20/4902 in placebo group
0/14964 in vaccine group
„The development of the Sputnik V vaccine has been criticised for unseemly haste, corner cutting, and an absence of transparency. But the outcome reported here is clear and the scientific principle of vaccination is demonstrated ...“
thelancet.com/journals/lance…
Authors end that comment in Lancet by pointing that the result „means another vaccine can now join the fight to reduce the incidence of #COVID19“.
Read 4 tweets
2 Feb
First results (yes, really!) on what #b117 + E484K might mean from @GuptaR_lab:
„Introduction of the E484K mutation in a B.1.1.7 background to reflect newly emerging viruses in the UK led to a more substantial loss of neutralizing activity by vaccine-elicited antibodies“
Quick explainer:
The researchers took blood from 23 people vaccinated with Pfizer vaccine and then checked how well it neutralized retroviruses that they had engineered to contain the spike protein of #b117 with or without E484K.
Preprint is here: citiid.cam.ac.uk/wp-content/upl…
Interpretation:
This is roughly what I expected given B.1.351 and P.1 data.
If you‘ve followed my reporting the last weeks you know that it is difficult to know whether/how much a drop in neutralization in the lab will translate into a drop in vaccine efficacy in the real world.
Read 7 tweets
1 Feb
And now for the bad news. *sigh*
It looks like #B117, the more transmissible variant first detected in England, has now picked up the E484K mutation as well. That is the one linked to evading SOME immunity in SAfrica and Brazil.

h/t @_b_meyer
assets.publishing.service.gov.uk/government/upl…
@_b_meyer "Preliminary information suggests more than one acquisition event.”

If this is true, it is one more sign that this mutation is a relatively easy way for the virus to acquire some advantage in populations with some immunity.
I worry that we will see this in many places with B117.
@_b_meyer And as @_b_meyer points out it may very well be that a mutation like N501Y makes it more likely for the virus to acquire this mutation because it almost “needs" it.
(Or as @K_G_Andersen would probably say: Maybe Nelly kinda seeks out the bad guys… )

Read 6 tweets
1 Feb
With all the breaking news on vaccines and variants I’ve barely had a chance to talk about this piece on microbes moving between humans and animals.
I think it’s important for the conversations we’re having around #sarscov2.
So, piece is here: sciencemag.org/news/2021/01/w…
And a thread
I’ve long been interested in the way infectious diseases affect wild animals and what we can learn about human disease from this.
So in 2019 I joined @Leendertz_Lab on a research trip to Taï National Forest in Cote d’Ivoire, where he has been studying this for 20 years.
@Leendertz_Lab The research station in Taï goes back to Christophe Boesch and Hedwige Boesch-Achermann who came to the forest in 1979 to study the chimpanzees. It took them years to habituate the animals (get them used to humans). Ever since then, researchers have been following them.
Read 15 tweets
29 Jan
More vaccine news, this time from phase 3 trial of Johnson&Johnson:
According to the company, their vaccine based on an adenovirus was 66% effective at preventing moderate and severe #covid19, 28 days after vaccination.

prnewswire.com/news-releases/…
Good news:
- Big study with 45,000 participants across multiple countries
-Vaccine was 85% effective in preventing severe disease overall
- all hospitalisations and deaths in placebo group
- efficacy against severe disease increased over time (no cases in vaccinees after day 49)
Most importantly:
This is a single-dose vaccine and only needs standard refrigeration.
That means of vaccines so far it is the easiest to distribute.
And plan is to produce one billion doses this year, so protection for one billion people hopefully.
Read 9 tweets

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