Becoming pretty clear now that dogs & cats can become infected by #B117.

Also, a London hospital had noticed a sharp uptick in the number of dogs and cats with myocarditis: From Dec 2020 to Feb 2021, the incidence jumped from 1.4% to 12.8%. #COVID19 🧵
sciencemag.org/news/2021/03/m…
2) That coincided with a surge of 🇬🇧 #B117 variant. Studying 11 pets: “eight cats and three dogs. None of the animals had a previous history of heart disease, yet all had come down with symptoms ranging from lethargy and loss of appetite to rapid breathing and fainting.”
3) “Lab tests revealed cardiac abnormalities, including irregular heartbeats and fluid in the lungs, all symptoms seen in human cases of COVID-19.”
4) “Seven of the animals got polymerase chain reaction tests, and three came back positive for SARS-CoV-2—all with the B.1.1.7 variant, team reported yesterday in preprint. antibody tests on 4 of the other animals picked up evidence that 2 of them had been infected.”
5) “Earlier this week, researchers at Texas A&M University detected the B.1.1.7 variant in a cat & a dog from the same home in Brazos county.
The Texas owner was diagnosed with COVID-19, and owners of 5 of 11 U.K. pets tested positive—all before their animals developed symptoms.
6) “The Texas pets showed no symptoms at the time they were tested, though they both began to sneeze several weeks later. All of the U.S. and U.K. animals have since recovered, though one of the U.K. cats relapsed and had to be euthanized.
7) “It’s “impossible to say” that pets infected with B.1.1.7 might play a more serious role in the pandemic, he adds, but “this hypothesis has to be seriously raised.”
8) scientists and veterinarians should do studies on role variants play in myocarditis among pets. The virus can cause the condition in people, so it’s worth exploring in companion animals. “It might be real,” he says, “but there’s no reason for people to freak out right now.”

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More from @DrEricDing

23 Mar
BREAKING—“A new pandemic”—Germany 🇩🇪 announces strict Easter lockdown. "What we have is essentially a new pandemic," Merkel said. The new variant #B117 is "significantly more deadly, significantly more infectious."

I’ve warned a new #COVID19 wave coming.
dw.com/en/germany-imp… Image
2) “German federal and state leaders have agreed on a radical shutdown over the Easter holidays.
Germany is extending the current lockdown through to April 18, German Chancellor Angela Merkel announced on Tuesday.
3) “The country will enter an even stricter lockdown from April 1 to April 5, over the Easter holiday period when shops, including grocery stores, will largely have to close.
Talks between leaders of 🇩🇪’s 16 federal states and Merkel lasted until the early hours of the morning”
Read 12 tweets
23 Mar
‘ONE NEAT TRICK’ for #COVID19 vaccine:

Yes, sounds clickbait-y, but there actually was a special technique developed to enhance the vaccine to be more effective—by adding a “double proline” (2-P) to stabilize the spike.

Took years to discover it! Neat.
cen.acs.org/pharmaceutical… ImageImage
2) “Graham’s lab had a template to work from because they’d spent several years designing an experimental mRNA vaccine for MERS.
But there’s a third, more subtle secret to their success: a tiny but oh-so-important tweak to a critical viral component called the spike protein.”
3) “Viruses multiply by dumping their genes into our cells and hijacking our cellular machinery to crank out new virus particles. But first, they need a doorway into our cells. Coronaviruses are studded with spikes, which grab hold of proteins decorating our cells like doorknobs.
Read 21 tweets
23 Mar
What caused plummet in business—#COVID19 or lockdowns?

@Austan_Goolsbee’s shutdown study:

“By comparing counties w/ & without restrictions, only 7% points of the 60% point overall decline in business activity can be attributed to legal restrictions."

➡️Virus was the reason.🧵 Image
2)
“Comparing consumer behavior within the same commuting zones but across boundaries with different policy regimes... While overall consumer traffic fell by 60% points, legal restrictions explain only 7 of that.”
nber.org/papers/w27432 Image
3) “Traffic started dropping before the legal orders were in place; was highly tied to the number of COVID deaths in the county; and showed a clear shift by consumers away from larger/busier stores toward smaller/less busy ones in the same industry.”
Read 12 tweets
22 Mar
SCHOOLS: Belgian Prime Minister says that schools are a hotbed of contamination and that children transmit the virus to their parents.

As result? 50% of all #COVID19 hospitalizations in 🇧🇪 are now under age 48 (parents of school children). This is affirmed by the Belgian leader.
2) Belgium 🇧🇪 Prime Minister also says: “The track & trace analysis shows that infections occur mainly in two places: in school and at work,” De Croo said at a press conference at the end of the Consultative Committee meeting.

brusselstimes.com/news/belgium-a…
3) “It has therefore been decided, where schools are concerned, that “the ministers of education need to come up by Monday with a list of measures to limit, to the maximum, the risk of infection,” he explained.”
Read 8 tweets
22 Mar
NO BLOOD CLOT RISK—In new AstraZeneca #COVIDVaccine trial in the US, Peru, and Chile:

➡️ No effects on blood clots observed in the 21,583 who were vaccinated, even with 60% of the people having some type of co-morbidity.

Really reassuring! 🧵 #COVID19
astrazeneca.com/media-centre/p… Image
2) 79% efficacy for symptomatic #COVID19 overall—100% efficacy for severe disease is amazing.

Even better - 80% efficacy in elderly. That’s super good that efficacy didn’t drop in the elderly. (In contrast, natural infection’s protection against reinfection plummets in elderly)
3) “This AstraZeneca-led US Phase III trial included two doses administered at a four week interval. Previous trials have shown that an extended interval of up to 12 weeks demonstrated greater efficacy, which was also supported by immunogenicity data...”
Read 5 tweets
22 Mar
Good: AstraZeneca vaccine has 79% efficacy in new trial in US, Peru, and Chile. 100% efficacy for severe #COVID19. Good safety profile.

WHAT WOULD HAVE BEEN BETTER: if US approved the vaccine back in Dec 2020, like UK 🇬🇧. Could have saved more lives. nytimes.com/2021/03/22/bus…
2) Dr @VincentRK is right again, we should not have waited for an “American trial” before approving something if clinical trial evidence already showed it was 60-90% efficacious back in December.

Lives have been lost by this “American trial first” approach.
3) AstraZeneca is now FINALLY filing for EUA with the FDA.

It hadn’t done so for all these months yet in the Us!!!
Read 5 tweets

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