THREAD on cases in the UK:

TLDR things going in right direction overall but some areas of concern for deprived communities & in schools. 1/19
Overall cases in the UK have fallen over last week after a long flat period. Note that tests have fallen too though (mainly lateral flow device (LFD) tests as schools are on holiday). 2/19
The ONS infection survey with data to 3 April - which tests random sample every week - reports new cases going *up* in England, flat in Wales and NI & going *down* in Scotland. 3/19
Cases are now 6-7 times lower than they were at January peak - back to where we were in mid-September last year.

But we're still almost 10x higher than in July last year (our lowest point). 4/19
There is also a difference regionally. The REACT study which tests about 100K people each month, found that while all regions decreased a lot since Feb, Northern regions have the highest rates (2x higher than the South) 5/19
And that difference in cases is also seen in hospital admissions - yes all regions have much reduced admissions (good) but the North has distinctly more than the South. 6/19
Part of the reason the North might be seeing higher cases is that it has more deprived regions than the South.

The most deprived communities have almost 3x as many cases as the least deprived as we leave lockdown. 7/19
I am worried about inequalities getting worse as we emerge from lockdown, with larger, more serious outbreaks in more deprived areas and concentrated in the North. 8/19
If we look at schools, ONS infection survey released modelled rates of Covid by year of age for each nation.
data here:
ons.gov.uk/peoplepopulati…

Let's look at Scotland which open schools first. 9/19
On 20th February, cases were mostly in working age adults.

On 22nd Feb, Scotland had a phased return to primary schools. 10/19
The ONS modelled estimates for 6th March (yellow), a couple of weeks later, show that while cases drop in older age groups, they have risen in younger ones. 11/19
And by 20th March (red), the modelled estimates are much higher again in younger people while among adults cases keep falling.

Now for some pros and cons... 12/19
Firstly pros: ONS is a random weekly sample so does not rely on people coming forward for testing or whether you have classic covid symptoms (important for kids). It's the best population indicator we have. 13/19
Cons: Number of people sampled in Scotland is not that high and there are quite large uncertainties attached. Plus the following week, ONS shows drops but the most recent week is usually an underestimate in ONS (& they flag it as more uncertain) so I've left it out here. 14/19
Also, ONS infection survey today shows overall cases in Scotland decreasing. This could be cos decreases in adults are offsetting increases in children or inaccuracies in the model or a combo of both 15/19
The confirmed case data in Scotland by age (dependent on testing behaviour and symptoms (in primary school kids)) does show increase in kids after schools open but with a flat trend in late March and declines over Easter holidays (as we'd expect) 16/19
In England, where all schools open on 8 March, ONS sees some increase in children and then a decrease in most recent week in primary school. 17/19
The REACT study shows a clear shift in most cases being in 5-12 year old children in the last two weeks of March in England. 18/19
Cases are likely to decrease during holidays. But by May, with schools open and shops, hairdressers, gyms etc opening we should expect increases. The question is: by how much? in which age groups? are deprived communities going to be hit harder? How much increase is "ok"?! 19/19

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More from @chrischirp

9 Apr
Three charts to highlight vaccine impact in England... Hospitals: For almost all the second wave hospitalisations were highest in the over 65s - but at the end of February the under 50s (unvaccinated) overtake over 65s in admissions... This is good news on vax impact! 1/3
Deaths: REACT released its latest report this week. In it they overlaid actual deaths onto infection trends adjusted for the time lag between infection & death and scaled for case fatality rate. Since Jan deaths have dropped off the infection line - more vaccine impact! 2/3
Deaths *and* Hospitals: Using published case, hospital and death data we see similar trends as this beautiful plot from @jburnmurdoch shows.

PHE estimates that vaccines have saved 10,000 lives so far! assets.publishing.service.gov.uk/government/upl…… 3/3
Read 4 tweets
9 Apr
Quick THREAD on vaccine progress in UK:

Firstly, vaccines have slowed down a bit since March - 1.6m jabs last week (but includes Easter weekend).

We are now giving mostly 2nd doses. Expect that to continue until end of May... should still be able to jab 40+ by end May tho. 1/6
53-58% of adults in UK have had a first dose of vaccine and 11%-18% have received a second dose.

Wales is storming ahead with its second doses! 2/6
Digging into English data now...

Almost 60% of over 80's have had their second dose which is great.

One thing to watch out for is whether we will get *everyone* coming back for their second dose across age groups - it's important to get full benefit from the vaccines. 3/6
Read 7 tweets
7 Apr
SHORT UPDATE THREAD on COVID and DEPRIVATION

This week @ShaunLintern highlighted the growing divide in case numbers between North and South in England.

Just adding a few more graphs as context for this really important issue. 1/5

independent.co.uk/news/health/co…
Firstly, overall there is a big difference in case rates between most and least deprived - almost threefold.

That means more deprived areas are in a much more precarious situation as we open up. 2/5 Image
But the size of the gap varies a lot by region - it's higher in the north and midlands than the south and highest by far in Yorkshire & the Humber.

This will be contributing to the higher case rates in the north.

London is by far lowest differential. I'm not sure why. 3/5 Image
Read 6 tweets
7 Apr
THREAD on English vaccine supply & what this might mean for the roadmap.

It was reported the other day that England will have relatively restricted supply for the foreseeable future
theguardian.com/politics/2021/… 1/9
This is based on the recent SAGE SPI-M modelling where the central estimate for vaccine supply was 2.7m doses a week in England from April -July and then 2m doses a week. This compares to 3.2m doses a week in February & March & the previous plan of increased supply. 2/9
This means that most of April AND May will taken up honouring second doses for the over 50s.

Under 50s won't be getting their first doses in any big numbers until June and July...

What does this mean for the roadmap? 3/9
Read 10 tweets
3 Apr
THREAD ON VARIANTS:
Some key bits from latest PHE report on Covid variants currently under surveillance in England.

TLDR: v low levels of everything apart from our Kent strain (B117) but S. African & Brazilian strains spreading.

Full report: assets.publishing.service.gov.uk/government/upl… 1/10
Variants with the "Eek" mutation (E484K) are of particular concern since this mutation is thought to help covid evade antibodies so that it can more easily infect people who have had covid already or (potentially) the vaccine.

bmj.com/content/372/bm… 2/10
Two variants with this mutation (the Bristol strain which is our Kent variant+E484K, and the Brazilian P2) are *not* spreading, but four variants with this mutation *are*. 3/10
Read 10 tweets
1 Apr
The latest @ONS infection survey includes breakdown by age for all home nations.

ons.gov.uk/peoplepopulati…

We're seeing two different epidemics by age (thx to @dgurdasani1 for phrase).

(expand gif to see corresponding dates and whole thing) 1/4
The increase in younger children after schools go back is very obvious in Scotland (after 22 Feb) and in England (after 8 March) while decrease in older ages continues.

So vaccination & restrictions offsetting opening of schools - this is good! BUT 2/4
With the release of latest long covid estimates from ONS infection survey today as well, I still don't think we should be complacent about lots of younger people reporting long covid (10%-13%).

ons.gov.uk/peoplepopulati… 3/4
Read 5 tweets

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