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Dr Sumaiya Shaikh Profile picture
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3 May, 4 tweets, 2 min read
Do not treat yourself with steroids like dexamethasone at home for asymptomatic and mild infections. It will prolong the length of the disease and you won’t be able to recover as easily. It can also add to more variants.

#CovidIndia
And where my opinion is coming from:
From people asking where this is coming from: see the last point of 2nd yellow box under mild disease. Recent ICMR protocol for Covid-19 treatment.

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Dr Sumaiya Shaikh Profile picture
17 Apr
Yesterday's report by @PriyankaPulla on the ANVISA decision of COVAXIN was heavily criticised suggesting the inactivation test was conducted and published by @BharatBiotech- contrary to ANVISA claim. However, the test was only ex-vivo. BB has not tested this in-vivo (rodents)..1n
...A 2nd step involving inoculation of amplified virus within in-vivo model followed by monitoring for the onset of disease symptoms should be performed. In the past, 2 inactivated vaccines, measles & respiratory syncytial virus (RSV) has had disastrous outcomes due to...2n
...the lack of appropriate testing for inactivation kinetics. Although COVAXIN is inactivated using beta-propiolactone & not formalin- like the other 2 vaccines, manufacturers need to practice immense precaution during development to avoid creating immuno-compromised people. 3n
Read 4 tweets
Dr Sumaiya Shaikh Profile picture
16 Apr
Is the health ministry doing enough to inspect the cause of COVID-19 surge?
To change strategy, we need to identify & sequence

Dr Vardhan claims SARS-CoV-2 genomics consortium is effectively processing the samples of the double variant.

Lets fact check:

#COVID19India #Thread
1. Yesterday, Indian State health officials said the double variant’s role cannot be ruled out in Maharashtra’s second wave. The state is recording over 50,000 new cases every day and has 5.64 lakh active cases, half of India’s Covid burden.
indianexpress.com/article/cities…
2. The B.1.617 variant has two mutations, E484Q & L452R. Both separately found in many other variants, but together, it was found for the first time in India on 5 Oct 2020
Both mutations are found in the spike protein that helps the virus to bind to our cell’s receptors....
Read 12 tweets
Dr Sumaiya Shaikh Profile picture
12 Apr
Lessons for professional & personal life. 🧵

For life during the COVID-19 2nd wave & beyond.
1. In medical education, teach an extra course called PPD (personal & professional development) which includes medical ethics, difficult conversations about end of life, breaking bad news to family, inequality in health, conflicts & global crisis,etc...
... in my medical school in Sydney, PPD was taught interactively for two hours, about 4 times a semester. They learn about conflicts as an issue of public health. (Looking at IMA’s response to Lancet). My class discussed Rohingya. In ‘end of life’ session, nearly everyone cried
Read 14 tweets
Dr Sumaiya Shaikh Profile picture
12 Apr
Sputnik V has 91.6% efficacy against COVID-19 & 100% against severe covid. 5 countries producing domestically incl. India & China. Aka GAM-COVID-Vac, it’s made of recombinant (S protein expressing gene of SARS-CoV2) adenovirus of 2 different serotypes (26 & 5)
Approved in India✅
PS it’s not Sputnik 5, it’s Sputnik V (the alphabet) probably a short to suggest it’s a viral vector vaccine. Sputnik 1 was also the first human-made satellite to orbit the earth.
Sputnik V is a double dose, 21 days apart vaccine. Both doses contain different serotypes of adenovirus. Single dose is not so effective (~85%). 2 way storage: 1. As a ready made water solution stored at -18•C OR 2. the freeze dried powder stored at 2-8•C & later mixed in water
Read 4 tweets
Dr Sumaiya Shaikh Profile picture
3 Mar
PSA for those who have registered/about to get COVID-19 vaccine via the Co-WIN app.
It is absolutely essential that those who have had immune suppressants like chemotherapy or during organ transplants, etc should make it known during the inoculation and avoid the #Covaxin jab.
Covaxin and other live attenuated vaccines should be avoided by:

1. HIV,
2. Cancer & chemotherapy,
3. Organ transplants
4. Taking steroids
5. Congenital immune deficiencies including complement deficiencies
6. phagocyte dysfunctions

Contd..
Read 5 tweets
Dr Sumaiya Shaikh Profile picture
24 Jan
COVAXIN Efficacy: A thread...

n0
Q1: Is there a method to hypothesise the efficacy of COVAXIN when no data has been released?
Q2: How is this efficacy enhanced & measured?
Q3: Why can’t COVAXIN be compared with other mRNA vaccines like COVISHIELD (AstraZeneca), ModeRNA and Pfizer?
n1
We know that COVAXIN, also known as BBV152, is based on a tested technology which inactivates or weakens the whole virus, in this case, SARS-CoV-2. NIV isolated the virus strain (NIV-2020-770) of the coronavirus from a COVID-19 patient and sequenced its genome.
n2 Schematic drawing of the 1D structure of coronavirus spike.
Read 26 tweets

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