2) That is about 38% higher than the current death estimate from the Centers for Disease Control and Prevention, 561,594.
➡️The new figure also surpasses the estimated number of U.S. deaths in 1918 flu pandemic, which was estimated to have killed approximately 675,000 Americans.
3) “We’re probably not yet at the global toll of Spanish flu and certainly not at the death rate from Spanish flu. But given what’s unfolding in India right now, Covid is going to rival Spanish flu at global level in terms of the count before we see the end of this epidemic”
2) To be clear, in the @NEJM article, the authors failed to define 1st dose and didn’t exclude the first 14 days of post vaccination followup. It was not disclosed until someone @supermarioelia asked in a direct written communication. Thus the paper’s 1st dose number too low.
3) For protection against severe disease, efficacy was 100% for 2 doses for the variants, 97% overall for all #COVID19 cases. That’s great.
2) Rundown hospital “conditions the government doesn’t want people to see. So we filmed secretly. Covid patients being treated amid other illnesses, cared for by their own family.” With toilets overrun in ICU.
3) “the people here are angry. The PM @narendramodi makes announcements on TV, but nothing reaches us”.
2) “variants are extremely concerning. Most data at this point shows anywhere from a 10-fold to a 30-fold reduction in nAb against the variants”
3) “When we mix these variants with elderly immune systems that will wane - we will see new cases emerge amongst fully vaccinated vulnerable in our communities this year. it will be bad in this fall and it will lead to outbreaks and deaths again.” 🔥
📍GET BOTH DOSES! Great variants & #COVID19 vaccine news—Pfizer/BioNTech vaccine had great efficacy of 89.5% vs #B117 🇬🇧 variant & 75% vs #B1351 🇿🇦 variant for infection—but only with 2 doses. The 1 dose efficacy was just ~29% vs #B117 & ~17% vs #B1351. 🧵 nejm.org/doi/full/10.10…
2) “Viral genome sequencing conducted from February 23 through March 18 indicated that 50.0% of cases of Covid-19 in Qatar were caused by B.1.351 and 44.5% were caused by B.1.1.7. Nearly all cases in which virus was sequenced after March 7 were caused by either #B1351 or #B117.”
3) To be clear—this was not a trial, but an observational case-control study. “Vaccine effectiveness was estimated with a test-negative case–control study design, a preferred design for assessing vaccine effectiveness against influenza (see the Supplementary Appendix).”