NEW—Emerging evidence indicates #COVID19 has distinctive pathophysiological features that set the disease apart from respiratory failure of other origins.

A new 4-part Series in @LancetRespirMed explores COVID-19: Pathophysiology of Acute Disease: hubs.li/H0NyR540
.@osuchm et al. provide a comprehensive Review of the pathophysiology and phenotypes of #COVID19. Read in @LancetRespirMed: hubs.li/H0NySMY0.
The challenges and promise of therapeutically targeting the pleiotropic cytokine interleukin-6 are considered in the 2nd & 3rd papers.

#Interleukin-6: obstacles to targeting a complex cytokine in critical illness—Oliver McElvaney et al: hubs.li/H0NyRjW0 (1/2)
#Interleukin-6 receptor blockade in patients with #COVID19: placing clinical trials into context—@fedeangriman, @BrunoFerreyro, et al: hubs.li/H0NyRKB0. (2/2)
The 4th paper, from Dennis McGonagle et al, considers the contributions of viral infection of the alveolar compartment and immunothrombosis of the juxtaposed pulmonary vascular compartment in severe #COVID19: hubs.li/H0NyRQ90.

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More from @TheLancet

17 May
Cardiovascular disease is responsible for 35% of deaths in women yearly—yet remains:
❣️Understudied
❣️Under-recognised
❣️Underdiagnosed
❣️Undertreated

NEW @TheLancet Commission outlines 10 recommendations to improve health outcomes for millions of women: hubs.li/H0Ns28Y0
275 million women were diagnosed with cardiovascular disease (CVD) in 2019. Acknowledging sex and gender-specific risk factors is the key to understanding #CVD in women and reducing the 🌍 burden.

Read the #LancetWomenCVD Commission: hubs.li/H0Ns28Y0
The global prevalence of cardiovascular disease in women has declined by 4.3% since 1990, but has risen in some of the world's most populated nations—🇨🇳(10%), 🇮🇩(7%), 🇮🇳(3%).

@TheLancet #LancetWomenCVD Commission provides regional recommendations: hubs.li/H0Ns28Y0
Read 5 tweets
26 Mar
Migraine affects over 1 billion people worldwide, is the 2nd leading cause of disability, and a major source of losses to the 🌍 economy—yet professional and political awareness is lacking. Read a new @TheLancet Series on #Migraine by @MessoudAshina et al. hubs.li/H0J-73-0
In 2011, migraine cost Europe an estimated €50-€111 billion. Evidence suggests primary care could meet the needs of most #migraine patients, where available. Read an overview of migraine epidemiology, global burden, and migraine care challenges. hubs.li/H0J-73-0
Migraine diagnosis is based on clinical criteria—criteria that do not capture migraine’s heterogeneity. Read about recent progress in disease characterisation, biomarkers of #migraine, and precision medicine for affected patients: hubs.li/H0J-73-0
Read 4 tweets
24 Mar
63 million lives have been saved since 2000 by global efforts to #EndTB—efforts at risk from #COVID19. Achieving @WHO's #EndTB Strategy targets requires urgent action and investment.

On #WorldTBDay, access related content from across The Lancet titles 👇
Every day, nearly 4000 people die from #tuberculosis. Although considered a public health emergency for over 25 years, only modest progress has been made.

On #WorldTBDay, explore how recent advances could revolutionise #TB control & care in this Seminar: hubs.ly/H0JPlsv0
An estimated 568,000 missing childhood #tuberculosis cases in 2019 were neither diagnosed nor adequately treated. With childhood TB cases on the rise, the case detection gap must be narrowed, writes @Esinofils, @TogunToyin, and @BeateKampmann. Read how: hubs.li/H0JPk5p0
Read 5 tweets
8 Mar
Maternal & child undernutrition remains a major health concern—the last decade saw little progress despite proven interventions & recent gains may be offset by #COVID19. A follow-up #LancetNutrition Series calls for global recommitment.

Read hubs.li/H0HRXR80
From 2005-15, nearly 5% of children had concurrent stunting & wasting in LMICs. For maternal nutrition, prevalence of undernutrition ⬇️, but anaemia & short stature remain high.

Read the #LancetNutrition Series: hubs.li/H0HRFfS0 & hubs.li/H0HRFlX0
Previously highlighted interventions continue to be effective at reducing stunting, micronutrient deficiencies & child death. Delivering nutrition interventions within the #first1000days of life if key.

Read the @LancetChildAdol Review: hubs.li/H0HRR310 #LancetNutrition
Read 4 tweets
18 Dec 20
NEW—COVID-19 causes more severe disease than seasonal influenza, confirms a Study of French national data from over 130,000 hospitalised patients published today in @LancetRespirMed: hubs.li/H0CRd__0 (1/4)
Nearly twice as many people were admitted to hospital for COVID-19 at the height of the pandemic than were for influenza at the peak of the 2018/2019 flu season; (COVID-19, 89,530 patients vs influenza, 45,819 patients) (2/4)
The death rate among COVID-19 patients was almost three times higher (number of deaths: COVID-19 15,104/89,530 [16.9%] vs influenza 2640/45,819 [5.8%]), and a greater proportion of COVID-19 patients experienced severe illness requiring intensive care. (3/4)
Read 4 tweets
16 Dec 20
Designed in 1948, the #NHS pay structure has not kept up with the changes in women’s position in society. The medical #genderpaygap in England has worsened as a result of #COVID19, and does not narrow until aged 65. Jane Dacre et al. Comment: hubs.li/H0CHQfJ0 Panel: Recommendations acro...
A recent review shows that the total medical #genderpaygap in England is 24·4% for hospital doctors, 33·5% for general practitioners, and 21·4% for clinical academics.
A severe reduction in child-care provision during the #COVID19 pandemic will have disproportionately stalled the careers of women in medicine; it is likely that most accommodations to adjust to the shortage of child-care will have been made by female doctors.
Read 4 tweets

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