There is a #B16172 variant-driven surge in parts of 🇬🇧—Bolton (near Manchester), where cases are rising fast in children & young adults. Some say this is a fewer vaccination effect in kids, some say it’s a testing surge, but it’s not clear if just testing. Need vigilance & masks.
2) some argue it’s surge testing because positivity is flat. But I’m not sure. See, if positivity % is flat, but cases rising—that means the new excess cases is real. Only if positivity dropping would it be testing driven.

Positivity flat + more cases = real increase.
3) Nerding a little: So surge testing increases volume of tests, which finds more cases, yes—but if Positivity is flat, it’s then sampling same underlying case fraction—ergo actual incidence is (likely) growing. If P% dropping, then it’s oversampling and incidence likely not up.
4) But it depends on a special ratio (which @euromaestro and I discussed it a lot last year). One can think of it more precisely as the ratio of relative “case increase : testing volume increase” — if the ratio >1, then then case increase is likely true incidence increase….
5) (continued)… however if that ratio is <1 —I.e. testing volume increase outstripping case increase (aka usually positivity % down), then incidence ~not going up. This ratio works even if testing volume drops too (volume drops faster than cases drop). @euromaestro @jburnmurdoch
6) many experts in the UK are asking for school mask mandate to be reinstated. Bolton UK is seeing a likely true surge.

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More from @DrEricDing

23 May
NEW—UK reports that 2 doses of AstraZeneca vaccine efficacy for #B16172 India variant: just 60%. And latest study says #B117 efficacy just 66% (lower than before). 1-dose efficacy 33% for #B16172.

Clearly #B16172 problematic in 🇬🇧 when 2/3 of shots is AZ
gov.uk/government/new… Image
2) that said, the Pfizer-BioNTech vaccine was 88% effective against symptomatic disease from the B.1.617.2 variant 2 weeks after the second dose, compared to 93% effectiveness against the B.1.1.7 variant
3) “both vaccines were 33% effective against symptomatic disease from B.1.617.2, 3 weeks after the first dose compared to around 50% effectiveness against the B.1.1.7 variant”
Read 4 tweets
23 May
Staggering—at least 3 million excess deaths in 2020–which is **1.2 mil** more than the 1.8 mil official numbers: WHO estimates that is the excess in the America & Europe alone (data not yet including Asia, Africa, Middle East).

I’m also imagining India 😢
who.int/data/stories/t… ImageImage
2) “Excess mortality is defined as the difference in the total number of deaths in a crisis compared to those expected under normal conditions. COVID-19 excess mortality accounts for both the total number of deaths directly attributed to the virus as well as the indirect impact”
3) what about undercount? “A recent assessment of health information systems capacity in 133 countries found that the percentage of registered deaths ranged from 98% in the European region to only 10% in the African region.” Damn! who.int/data/data-coll…
Read 7 tweets
22 May
Muzzling risks in schools—Downing Street (Boris Johnson) censored @PHE_uk and prevented crucial data on spread of new #COVID19 variant in schools—notably blocking data on Indian variant school spread. Scientists & teachers said it was “deeply worrying”. 🧵
theguardian.com/world/2021/may…
2) “The focus of their anger concerns the pre-print of a PHE report that included a page of data on the spread of the India Covid-19 variant in schools. But when the report was published on Thursday 13 May, the page had been removed.”
3) “It was the only one that had been removed from the pre-print. Days later, the government went ahead with its decision to remove the mandate on face coverings in English schools.”
Read 11 tweets
22 May
TWO DOSES NEEDED—New UK vaccine data finds 1-shot protection for symptomatic infection of #B117 variant is 51%, and just 33% versus #B16172 from India. However, after 2 doses—87% for #B117 & 81% for #B16172. But mixed 3 vaccine types—unclear AZ vs mRNA. 🧵
ft.com/content/a70d42… Image
2) “This suggests a single shot offers 35 per cent less protection against B.1.617.2 compared with B.1.1.7, according to Financial Times analysis.
The PHE figures aggregate data from the BioNTech/Pfizer and Oxford/AstraZeneca jabs.”
3) “The rapid spread of B.1.617.2 in pockets of England has cast doubt on the country’s road map out of lockdown, with the next phase due to take place on June 21. “PHE scientists are evaluating the effectiveness of vaccines against B.1.617.2 variant” & will publish data later.
Read 8 tweets
22 May
Reopening schools in Texas potentially led to ~40,000 cases of #COVID19 and hundreds of deaths in Texas last year, study finds— “robust evidence that reopening Texas schools gradually but substantially accelerated the community spread of COVID-19." 🧵
abcnews.go.com/Health/rapid-s…
2) according to an analysis by economists and public policy experts from the University of Kentucky, analysis estimate that ~43,000 people contracted COVID-19 and 800 people possibly died in Texas two months after schools reopened statewide, when virus transmission was high.
3) The research highlights how in-person learning and its potential "spillover" can affect nearby communities.
Read 11 tweets
22 May
CDC needs to up its game:

“Forget ‘Stop the spread,’ you should be calling it ‘Stop the shrink!'”

HT @nbcsnl #COVID19 #CovidVaccine Image
2) new study—“two men following bouts with #COVID19 infections. 6-8 months afterwards, they still had virus particles in their penises. Not only that. They had developed severe erectile dysfunction (ED) even though they hadn’t had ED prior”. @bruce_y_lee
google.com/amp/s/www.forb…
3) “Examination found Covid-19 coronavirus particles near the blood vessel endothelial cells in the samples from the two patients who had had Covid-19. Blood vessel endothelial cells are cells lining the insides of the blood vessels in the penile tissue.”
Read 5 tweets

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