What is the incidence of VITT after 2nd AZ vaccination? The MHRA are saying 1.3 per 1 million. I say it may be a lot less and could be zero. #VITT #COVIT19 1/7
We do not know much about the 2nd dose VITT cases that the MHRA claims to have had reported to them. They are all >50 but we do not know anything else. Why do they not publish type of thrombosis, age, sex, co-morbidities, anti-PF4? 2/7
It is accepted that the MHRA have had 18 reports of thrombosis with thrombocytopenia after 2nd dose AZ vaccine. But are they VITT? Do they definitely not have cancer or sepsis? Do they fulfil the attached typical VITT definition? 3/7 Image
Why would the age of the VITT affected persons be so completely different if it is after a 1st or 2nd AZ dose? Could it be that the older persons have alternative co-morbidities that could account for the thrombosis and thrombocytopenia? 4/7
Why has there been only 1 new report of 2nd AZ dose VITT in 1 week, if so many more people are being vaccinated with 2nd AZ doses in the UK? 5/7
I have still not heard a convincing case of 2nd AZ dose VITT, nor spoken to a UK haematologist who has seen a case. 6/7
It is possible that cases may still appear as more people get a 2nd AZ vaccination. However in the UK so far, 13.4 million persons have had a 2nd AZ vaccination and this includes 2.7 million aged 18-49 years. 7/7

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More from @ProfMakris

29 May
Health care workers and carers >18 years in the UK could get any vaccine relatively early on. Because of the Pfizer storage requirements, it was used largely in hospital vaccination sites. So in UK, hospital staff largely got Pfizer in contrast to Norway/Germany who got AZ. 1/4
In the UK this was a logistics issue since prior to March we knew nothing about VITT. Many European countries felt the efficacy data for the AZ vaccine were not strong for >65, so gave Pfizer to >65 and AZ to <65. 2/4
In Norway and Germany where the decision was to use AZ for <65 years, they also decided to give it to health care staff first. Since health care staff are more likely to be female, there was a large female excess in the persons who developed VITT. 3/4
Read 4 tweets
22 May
What is the risk of vaccine-induced immune thrombocytopenia and thrombosis (VITT) after a 2nd AZ vaccine dose? This is the commonest question I get at present on twitter, email and in clinic. 1/6
The information released by the MHRA (the UK regulator) two days ago on their website stated that they have had 15 cases of 2nd dose VITT after 9 million 2nd doses of the AZ vacc administered (ie 1 VITT case every 600,000 2nd doses of the AZ vaccine). tinyurl.com/s53nf2w 2/6
If the rare of VITT in the UK after 2nd doses of the vaccine was the same as after the the 1st dose, we should have had (309-15)x9/23.9= 110.7 cases. According to the MHRA we have had 15 but expected 110. 3/6
Read 6 tweets
20 May
I am pro-vaccine and especially so when it comes to #COVID19. I have participated in the vaccine clinical trial and will do so again. I have had AZ x2. I believe people should be provided with all the available information to allow them to make a decision before vaccination. 1/4
Q1 to @MHRAgovuk: It is great that you provide the cases of VITT post AZ vaccine by decade of age. Please also provide the number of persons vaccinated with AZ by decade of age so the rates of VITT can be calculated. 2/4
Q2 to @MHRAgovuk: Have there been any VITT cases after Pfizer vaccination reported? If yes, how many? 3/4
Read 4 tweets
22 May 20
Today has been the most important day in terms of high quality publications on COVID-19. Up to now amazingly 15425 manuscripts have been published in scientific journals. However 4 of the top 10 papers ever published on COVID-19 were published today. #COVIDー19 #Coronavirus 1/5
PAPER 1: The trial which was presented by Fauci on Remdesivir in COVID-19 has just been published by the New England Journal of Medicine. The benefit is modest but it is one of the very few RCTs with a positive result. tinyurl.com/y8s46vc7 2/5
PAPER 2: Huge observational study shows that the use of hydroxychloroquine in COVID-19 is associated with reduced survival. OK not an RCT but sufficiently powerful to limit use of hydroxychloroquine to clinical trials only. tiny.cc/gywjpz 3/5
Read 5 tweets

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