📍Nearly 2/3 of Russians say they do not plan to get the Sputnik vaccine. Analysts attribute hesitancy to: widespread distrust of 🇷🇺 authorities, & frequent state television reports that #COVID19 as mostly defeated or not dangerous… And now a new surge.🧵
2) “Russian officials scrambled on Saturday to slow the spread of a new wave of the coronavirus, ordering workers in Moscow to take next week off and pleading with the populace to make use of widely available vaccines.
3) “The biggest spike appeared to be in Moscow, the Russian capital, which reported 6,701 new cases on Saturday — more than double the rise five days ago, and the highest single-day total since December. “
4) “Mayor Sergey S. Sobyanin said the situation had “sharply worsened” in the past week, and that thousands of hospital beds were being repurposed to provide care for Covid-19 patients.
5) ““According to epidemiologists, it is now necessary to at least slow down the speed of, if not stop, the spread of the virus,” Mr. Sobyanin said on his blog.
6) “Most employers will be required to keep workers home — with pay — next week. However, Mr. Sobyanin ***did not impose new restrictions on indoor dining*** beyond the 11 p.m. cutoff”

Hellooooo… #COVIDisAirborne

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More from @DrEricDing

14 Jun
⚠️New CDC warning on rising RSV again. Coincided with dropping of mask mandates & usage. ➡️ “The CDC is issuing this health advisory to notify clinicians and caregivers about increased interseasonal respiratory syncytial virus (RSV) activity across parts of the Southern US.” 🧵 Image
2) CDC: “Due to this increased activity, CDC encourages broader testing for RSV among patients presenting with acute respiratory illness who test negative for SARS-CoV-2, the virus that causes COVID-19. RSV can be associated with severe disease in young children and older adults”
3) “RSV is the most common cause of bronchiolitis and pneumonia in children under one year of age in the United States. Infants, young children, and older adults with chronic medical conditions are at risk of severe disease from RSV infection.
Read 7 tweets
14 Jun
So, vaccines good against hospitalizations, yes, but not when just 1 dose against #DeltaVariant, not when <50% fully vaxxed. Despite new controversial case-control efficacy study (very small & assumption laden)—🇬🇧hospital #COVID19 surges just don’t lie.🧵 assets.publishing.service.gov.uk/government/upl… Image
2) Note how much weaker 1 dose is versus 2 doses for the #DeltaVariant for both infection and hospitalization. ImageImage
3) What is the first clue the new controversial study is unreliable? The Pfizer 2 dose results aren’t even significant due to wide 95% CIs. Second, the 1 dose is stronger than 2 dose for Pfizer? Hog wash. We know that’s not true and opposite. This is why this study unreliable. Image
Read 4 tweets
14 Jun
Masks are coming off—the cold and flu is now back. Coincidence? No. The CDC just issued a health advisory about increased cases of respiratory syncytial virus, or RSV, across parts of the southern US — something CDC hadn’t seen since April 2020. #MaskOn
2) RSV is a cold-like respiratory illness that produces symptoms similar to COVID, and can cause severe illness in older adults and young children. It disappeared for a year because of #COVID19 mitigations. It’s now back because masks are coming off, especially in the South.
3) Since the state’s mask mandate was lifted at the end of May, face coverings have started to come off — and stay off. But according to infectious diseases doctors, the return of facial freedom might come with some downsides, like a resurgence in cases of the common cold and flu
Read 10 tweets
14 Jun
So a controversial #DeltaVariant study did not find a sig 2-dose effect for Pfizer, yet still claims a significant efficacy. It also claims AstraZeneca hospitalization relative risk is lower than Pfizer—opposite last week—also from weak case control design—wouldn’t bank on it. 🧵 Image
2) This (left photo) is the standard VE formula. Yet this (right photo) is the modified calculation of VE used in this study. It requires a completely diff set of assumptions and then mashes the two different sets of numbers together. ImageImage
3) there are many assumptions in order for their formula. It’s very risky and tricky.

“Biased [vaccine efficacy] effect-size estimates arise if either condition is unmet.”

pubmed.ncbi.nlm.nih.gov/30099505/ Image
Read 5 tweets
14 Jun
⚠️Annoyed—the US CDC still does **not seem to classify the #DeltaVariant as a “Variant of Concern”**!! #B16172 is still merely “variant of interest” on @CDCgov website, updated just this weekend. Both @WHO & 🇬🇧 upgraded Delta to VOC weeks ago. CDC act now! cdc.gov/coronavirus/20… Image
2) Because this is what new cases of #DeltaVariant #COVID19 is doing in the UK 🇬🇧… US 🇺🇸 is a trouble if don’t act now
3) Is #DeltaVariant growing quickly in the Us? Yes. Hell yes. Yet CDC doesn’t rate it a VOC.
Read 10 tweets
14 Jun
Good news—Novavax protein-subunit vaccine phase 3 trial shown to to be 90.4% effective overall, 100% against moderate to severe disease. This is different type from mRNA and from AZ/J&J adenovirus vaccines, and different from inactivated types. #COVID19
2) Here is a good refresher on how the Novavax vaccine works. nytimes.com/interactive/20…
3) The protein units of the spike are harvested and then assembled together. There is no virus—just proteins linked together.
Read 5 tweets

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