A mixed schedule of vaccines where a shot of Pfizer #COVID19 vaccine is given four weeks after an AstraZeneca shot will produce better immune responses than giving another dose of AstraZeneca, an Oxford study said on Monday. 🧵 reuters.com/world/uk/immun…
2) study compared mixed two-dose schedules of Pfizer and AstraZeneca vaccines, and found they produced high concentrations of antibodies against the spike protein. The data provides support for the decision of some countries offering alternatives to AstraZeneca as a second shot
3) The highest antibody response was seen in people receiving two doses of Pfizer vaccine, with both mixed schedules producing better responses than two doses of AstraZeneca vaccine.
4) An AstraZeneca shot followed by Pfizer produced the best T-cell responses, and also a higher antibody response than Pfizer followed by AstraZeneca.
5) Com-COV is also looking at mixed schedules over a 12-week interval, and Snape noted that AstraZeneca's shot was known to produce a better immune response with a longer interval.
In 🇬🇧, officials use an 8-week gap between doses for over-40s and a 12-week gap for other adults.
In 🇬🇧, officials use an 8-week gap between doses for over-40s and a 12-week gap for other adults.
6) this Oxford study confirms the earlier Spain study that found the exact same thing - switching from AZ first dose to Pfizer second dose better than two AZ doses.
https://twitter.com/drericding/status/1394788638303539200
7) 3rd dose also tested as well. Pretty neat results.
https://twitter.com/DrEricDing/status/1409684402662117387
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