[Thread] 1. Glenda Gray, @MRCza: How effective are different #COVID vaccines @ the Beta variant (B.1.351)?
* #JnJ: 64%
* Novavax: 48.6%
* AstraZeneca: 10%
2. Early lab data shows that the #JnJ vaccine works against both the Beta and Delta variants, but better against the #DeltaVariant.
3. Do we need to boost the #JnJ vaccine with a second shot (currently you only get one shot)? Not yet. Data shows that an immune response is maintained over time from a single shot for up to eight months after vaccination.
4. This slide shows how the #JnJ jab works @ the Beta + #DeltaVariants (Beta = B.1.351; Delta = B.1. 617.2). Why don't we have a final answer re if we need to boost the 1st #JnJ shot? We only have data for 8 mnths after vaccination. We don't know if immunity will wane after that.
5. Data from the #Sisonke study that will be released soon, shows real-word effectiveness of the #JnJ vaccine and that it works well against both the Beta and Delta variants in South Africa.
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🧵1. BREAKING: The peer-reviewed results of the study of a 6-monthly jab, #lenacapavir, in which not a single of the 2134 women between 16-25 years who received the jab contracted #HIV, were released at #Aids2024.
2. Women often find it hard to adhere to daily #oralPrEP. In the Purpose 1 trial, 91.5% of women returned on time for their next #lenacapavir jab at 26 weeks and 92.8% at week 52.
3. Only 4 women out of 2134 (0.2%) who received #lenacapavir dropped out of the trial because of injection-site reactions.
[Thread] 12 things to know about the the proportion of pregnant women infected with #HIV from SA’s latest antenatal HIV survey. The survey is conducted by the @nicd_sa.
(Analysis of our 95-95-95 goals in my next thread later in Jan).
1/12
2. What is the antenatal #HIV survey?
1. It measures the % of HIV+ pregnant women between the ages of 15 + 49. 2. Only women using state pregnancy clinics take part. 3. The survey has been conducted each year between 1990-2015, then in 2017, 2019 +2022.
3. How many pregnant women between 15-49’s blood was tested for #HIV? 37 828 out of 40 542 collected samples.
- 37 7171 = Black African women
- 37 541 didn’t live with the dad of their child
- 35,635 of dads were 5 years+ older than moms (this makes them more likely to get HIV)
JUST IN [Thread]:
1.@healthza's Lesley Broomberg:
An extra #COVID19 booster jab for people of 18+ in SA will become available towards the end of JANUARY
- People of 50+ qualify for a 5th dose
- People of 18+ qualify for a 4th dose
2. Lesley Broomberg: Can you mix and match with additional boosters? Yes. You can choose whether you want a #JnJ or #Pfizer booster.
3. Lesley Broomberg:
Will teens of 12-17 qualify for boosters? Not at this stage. Why not? The #VMAC = not recommended booster doses for 12-17, based on an understanding that the protection provided by 2 #Pfizer doses = adequate, as 12-17 = @ low risk of severe #COVID19 illness
[Thread] #JoePhaahla:
- Genomic surveillance Network reported the detection of the new subvariant XBB.1.5 in SA of a sample of a patient tested on 22 Dec
- Details of the patient = not known, it was a random sample taken for testing
- XBB.1.5 = also common in US
2. XBB.1.5 = common in US
#JoePhaahla:
- 97%+ of #COVID19 cases worldwide = still #Omicron
- XBB.1.5 cases = no major change in hospitalisations or deaths
- Immunity of SAs (vax and natural immunity) = still strong, so that is why we haven't seen much change in terms of hospital admissions/deaths
Which APIs will Aspen use?
India's Serum Institute's
2. Why is it NB that an African company makes these jabs?
#Africa imports almost all its jabs. #COVID19 showed us this results in Africa being last in line to get vaccines during pandemics. The grant to Aspen is 1 of the 1st steps to change that.
3. What's the goal?
By 2040, the African Union wants #Africa to make 60% of the jabs the continent uses.
Why?
So that Africa is better equipped 2 respond 2 outbreaks (by developing the ability to make jabs + have technology in place to also make new jabs during pandemics).
🧵1. BREAKING: @SAHPRA1 has confirmed the registration of the #HIV prevention jab, #CABLA in South Africa. On Thursday, #ViiVHealthcare issued their statement.
2. Who can use the jab? @SAHPRA1 didn't specify restrictions for use in their statement, only that it is "a highly effective option for people at substantial risk of #HIV infection."
3. How does the jab work? It uses an #ARV called cabotegravir that prevents #HIV from replicating and entering someone’s cells. It’s taken every two months. Read my latest story for more. bit.ly/3ER7ejq