Absolute terror reigns over many #AVCT shareholders this week- simply because @avacta hasn't announced orders for its LFT yet.
Question: would #AVCT be lining up 30m per month capacity overseas, if it thought its existing 5m per month capacity in the UK wouldn't be filled? 1/13
Many seem obsessed with the UK market, thinking that's the be-all and end-all for #AVCT's AffiDX LFT.
My view is that mgmt had turned its back on the UK market several months ago, when it was apparent that there was, at best, complete ineptitude; or, at worst, corruption... 2/13
...at the top of certain UK Gov bodies. I'm referring to both the continued inexplicable support of Innova, and to the stonewalling of @mologic and UK Diagnostics PLC in general.
The FDA's actions against Innova may well have changed #AVCT's stance re: dealing with HMG. 3/13
Indeed, given AffiDX's world-leading sensitivity, its easy-to-use AN sample collection method, its ability to detect Delta without issue, and its "Made in the UK" tag line - I do think many will question DHSC, if #AVCT's LFT is not used going forward in schools / the NHS. 4/13
If it does, then #AVCT's LFT output could reach 60m+ pm quite quickly.
But instead of getting wound up by potential DHSC contracts, and setting oneself up for potential disappointment, I think the focus should be on reaching that goal of 35m per month sold into EU within Q4 5/13
The fearmongers are out in force on Twitter and the bulletin boards this week, calling for the end to the age of testing. These online platforms can be a great source of info to investors, but equally very dangerous. As it's not financial advice, I do feel comfortable in... 6/13
...advising: filter, mute and block - liberally. It's counter-productive arguing with a troll that wants to be argued with.
As to #COVID19 testing coming to an end - I will repeat the analogy I've used before: 9/11. Airport security was changed materially and irrevocably... 7/13
...in its wake.
The economic, social and psychological damage that #COVID19 has caused to mankind is so extensive and long lasting that the most effective countermeasures - vaccines AND highly accurate rapid testing - will be around for many years.
The current issue... 8/13
...at least in the UK, is that Innova has severely damaged the reputation of the LFT as a tool.
The majority of the public will not yet realize that there are dozens of different LFT models, nor appreciate the gulf of difference in quality between them - so great that... 9/13
...they are hardly comparable. The highest quality LFT may pick up 95+ cases out of 100 of infectious cases with low viral loads. The low quality LFTs may correctly identify <10 of that population.
In time, however, particularly after the UK Gov stops handing out free... 10/13
...LFTs to the public, product quality - and thus brand recognition - will come to the fore. Boris is leaving the handling of #COVID19 to the people going forward: what LFT will people want to use - will they buy for themselves - when they want to visit elderly relatives?
11/13
Major orders for AffiDX will come; of that I have no doubt. But as I Tweeted recently, the even greater benefit to #AVCT of launching the AffiDX #COVID19 LFT is that the global diagnostics industry has now seen what the Affimers Diagnostics platform is capable of. 12/13
@avacta has the global patent over usage of Affimers in Diagnostics into the 2030s. The AffiDX brand has huge growth ahead.
My view: Affimer Diagnostics will ultimately be acquired for (much) more than #AVCT's current mkt cap.
The three Therapeutics platforms: a free ride 13/13
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@guildesports#GILD is making all the right steps, is expanding incredibly quickly, and winning more trophies than it has had any right to do in its first year of operations.
The Academy could quickly become a key competitive advantage. 1/7
It could create value for #GILD in so many ways. Monthly subscription revs could build quickly - only 17k subscribers would be £1m ARR.
It provides an incredible scouting outlet and feeder system for upcoming talent. Hopefully we’ll see the first academy contracts in the… 2/7
…not too distant. Imagine in a few years’ time #GILD being able to field teams largely or even wholly comprised of Academy-generated talent.
My take on player transfers is that in 2-3 years, Esports transfer values could be 10x the size of what they are today. In 5-7… 3/7
University of Leeds (@avacta's academic partner) has been able to bind Affimers to the mutated form of the RAS protein, AKA the Death Star, which is responsible for 20-30% of all cancers.
Amy Turner, co-author: "RAS really is the Holy Grail of therapeutic targets. The fact that it has previously been termed 'undruggable' has allowed us to demonstrate the huge impact that our Affimer technology can have when it comes to treating challenging pathologies."
2/5
We have seen in recent months how #AVCT's Affimer Diagnostics platform has outperformed monoclonal antibodies (and other antibody mimetics), in the Affimer-based #COVID19 LFT and ELISA.
Now we have an example of Affimers' superiority (dare I say uniqueness?) in Therapeutics. 3/5
Fabulous to see @guildesports' @taysonFN win the Fortnite Champion Series All-Star Showdown last weekend.
#GILD talent has been a tad subdued on field the past couple of months, but three top 40 finishes (including first place ⬆️) in a major FNCS event is superb.
...construction ready. It's doubtful that any new production will be able to come online within the next two years - apart from the primary producers, #BMN and $LGO, expanding their operations.
@BushveldMin_Ltd owns two of only four primary production operations worldwide. 2/11
It is incredibly leveraged to the V price, which itself is illiquid and prone to exceptional moves.
With the global economic recovery driving steel output to all-time highs, demand for V (which is primarily used to strengthen steel) is steadily increasing.
ST trade: multiple purchases this week in #AVCT, av. 169p. Separate from core LT hold.
'Bad' news (i.e. slower build up in manufacturing capacity than envisaged by most; no commercial orders yet) now out of the way; potential for major and frequent positive news flow ahead. 1/12
Worst case scenario for #AVCT is that it'll sell 3m to 5m LFTs a month from August, for the next 3 years. That'll be £3m to £5m gross profit per month.
With clinical trials now commencing, assume annual cash burn increases to c.£30m.
@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.
A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10
In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.
The pre CISION tech is simply an attempt to improve the safety profile... 2/10
...of the chemo.
Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.
In pre-clinical mouse models for #AVCT's AVA6000 3/10