Thread by @BooSoonYew67

This is a very good & objective study showing that waning antibody levels in vaccinated individuals will be inevitable.. 1/n
thelancet.com/journals/lance…

The sample size is good.. n = 605, from participants in England & Wales.. 2/n
thelancet.com/journals/lance…

And the results..
A significant trend of declining S-antibody levels seen in BOTH ChAdOx1 & BNT162b2 #vaccines or the #AstraZeneca & #PfizerBiontech respectively.. 3/n
thelancet.com/journals/lance…

A closer scrutiny shows the following groups having higher initial S-antibody levels:
1) women > men
2) 18-64y > 65y or more .. 4/n
thelancet.com/journals/lance…

Here is the immediate comparison of full results for ChAdOx1 (AstraZeneca) & BNT162b2 (Pfizer) #vaccines .. the antibody levels .. are different times of sampling; in terms of days after receiving dose.. 5/n thelancet.com/journals/lance…

With this result.. should we express concern ? At the moment no..
As mentioned, data suggests "substantial underlying heterogeneity" within the clinical vulnerability groupings.
Plus, memory B-cell populations appear to be maintained.. 6/n
thelancet.com/journals/lance…

And there are admitted confounding factors like:
1) age
2) dosing interval
3) even small sample size
(n = 605 was considered was these researchers !!) ..
To improve, repeat with:
1) bigger sample
2) longer longitudinal follow-up till 6-12 months.. 7/n
thelancet.com/journals/lance…

It's accepted that higher antibody levels offer greater protection, and whatmore with the VOCs right now, especially #DeltaVariant ..

Yet, there is accumulating data suggesting T-cell-mediated immunity. More to learn actually !! .. 8/n
thelancet.com/journals/lance…

Lastly an apt closing remark by the researchers who declare no competing interests. Mentions the funding from a grant, that even received USD 15,000 of Facebook advertising credit to support pilot social media recruitment campaign !! 👍🏻👍🏻
thelancet.com/journals/lance…

@threadreaderapp .. unroll .. TQ