There's a lot to dig in here but a few things that jump out about Delta particularly:
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Delta objectively spreads faster than the original COVID strain. The original strain was less transmissible than polio & smallpox; Delta is more transmissible than those as well as Ebola, MERS, SARS, & the Spanish Flu.
Delta is *as* transmissible as chicken pox.
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Delta is associated with a higher viral load and longer duration of shedding.
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A big one: breakthrough cases from Delta may be as transmissible as unvaccinated cases.
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Data suggesting that Delta may cause more severe disease.
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Some preliminary data show that the vaccines may be less protective against non-hospitalized symptomatic infections of Delta. (This is bad news & will likely mean more #LongCOVID cases.)
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From the CDC's model, Delta cannot be controlled without universal masking!
This seems to be where their change in policy is coming from.
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Finally, a list of much needed changes to public communication from the CDC, including to "acknowledge the war has changed". Delta is different & concerning, and vaccinated individuals still are at risk.
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In short: we are not through the woods, and the CDC's de-masking recommendations came too early.
Everyone should return to masking & should be aware that being vaccinated can't be the sole means of protection on its own, but instead used alongside other precautions.
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Vaccinated individuals are less likely to be hospitalized & die, but with Delta they risk transmitting COVID to others, including unvaccinated kids (who seem to be at greater risk from Delta).
They also remain at risk of contracting #LongCOVID from breakthrough infections.
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There are many ways to engage with #LongCOVID patients as a researcher without joining support groups, which compromises patients' privacy.
In addition to @patientled (associated with the @itsbodypolitic support group), here are a few options researchers may not know about.
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The COVID-19 Research Involvement Group has been around since spring 2020 and run by patient-researcher @Know_HG. It's associated with @long_covid support group and has over 2500 patients and researchers discussing Long COVID.
The Medical & Scientific Collaboration group has been around since summer 2020 & is run by the renowned Long Haul COVID Fighters support group (@Amy_Ant, @katemeredithp). It also has about 2500 researchers & patients discussing avenues of research:
Happening now! I'll try to live tweet as I'm able.
Note: there are a few times where Q&As are welcome from the public! Questions can be pasted in the chat and will be answered during specific time slots. See the agenda for those times.
Proud to have been a Subject Matter Expert to the POTUS Health Equity Task Force!
They're presenting today on what they learned about #LongCOVID (hhs.gov/live) & their presentation is so full of good recommendations that I can't even keep up.
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I'm thrilled at their takeaways, including 1) lab confirmation of COVID can't be required for care, 2) creating a federal advisory committee including LC patients, ME experts, & disability advocates, 3) help patients navigate the disability system & expediting claims, & others 2/
Excellent public comments from Michael Sieverts on how biases in PCR and antibody testing will trickle their way into research. Super important as research plans for #LongCOVID are currently being decided....
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On those who participated in the survey on the clinical case definition - Patient AND Researcher is a new category (requested by @Dr2NisreenAlwan and yours truly) :)
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The parts of the clinical case definition that have reached consensus:
@itsbodypolitic and @patientled worked together to give feedback on these and it's really emotional to see our research, including the first report we did back in April 2020, cited here. 1/
It's going to take a while to go through & see what ended up in here, but a few things stand out to me that we pushed hard for:
A) The inclusion of a comprehensive symptom list, including PEM (and a definition for PEM!) and lesser-discussed but common symptoms. 2/
B) Instructions not to use lab confirmation: "Objective laboratory/imaging findings shouldn't be used as the only assessment of a patient’s well-being; lack of laboratory/imaging abnormalities does not invalidate the existence, severity, or importance of a patient’s symptoms." 3/
These areas of research are less known, including metabolic profiling, antiviral response phenotypes, neuroimmunology, cerebral blood flow, mitochondrial fragmentation, viral persistence, hypermobility, craniocervical issues, altered T&B cells, metabolomics & proteomics, etc. 2/
These researchers have made astounding post-viral findings in the above areas. Everyone interested in #LongCOVID should stop treating this as an illness unlike any other and instead dive into the massive amount of research that has already been done. 3/