MIXING SHOTS—The elephant in the room that FDA/CDC has completely failed to address is mixing boosters—especially for J&J & Moderna recipients who are still waiting—J&J most urgently. Angela Merkel 🇩🇪 had gotten AZ + Moderna. Canada allows mRNA mixing. 🧵 medpagetoday.com/special-report… 
2) mixing and matching became something of a necessity in Europe, as vaccine hesitancy with AstraZeneca ran high there following reports of unusual blood clotting. Many European countries moved ahead with mixing and matching AstraZeneca with mRNA vaccines. medpagetoday.com/special-report…
3) Two trials from across the pond -- one in Spain (CombiVacs) and one in England (Com-COV) -- as well as smaller cohort studies, "consistently show that you get a stronger antibody response when you give AstraZeneca followed by one of the mRNA vaccines," Moore said.
4) "Two AstraZeneca shots are weaker than anything containing mRNA," he said. "It's weaker than one AstraZeneca plus an mRNA or two mRNA shots."
5) to be fair— CDC's Advisory Committee on Immunization Practices (ACIP), many panelists seemed to be in favor of "heterologous boosting." — but they just pondered it, no action taken yet. Too much talk. Too little action. medpagetoday.com/infectiousdise…
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