A short thread on a recent publication from @HiyaaLab, in Translational Psychiatry. The study shows that the dendritic structure & electrical properties of adult neurons in healthy brains depend on proactive regulation by the gene Tcf4, a high risk allele for #Schizophrenia.
1/7
1/7
The #research reveals unexpected gene-networks, previously known to be involved in ciliary pathways, underlie #structural and #functional integrity of mature neurons in the healthy adult brain.
2/7
2/7
Given that the elaborate #dendrites & spines enable a neuron’s physical and electrical connectivity in a #neural circuit, alteration in the structure disrupts neuronal function, affecting the circuits and #cognition. 3/7
Thus, revelations about these new and unanticipated networks of genes—regulating adult neuronal structure—are likely to open new directions of investigations for better insights into neuronal maintenance in the adult mammalian brain.
4/7
4/7
What’s next?
Understanding a) how the identified gene-networks maintain structure-function of adult neurons, and b) why neurons have the innate ability to morph their structure.
5/7
Understanding a) how the identified gene-networks maintain structure-function of adult neurons, and b) why neurons have the innate ability to morph their structure.
5/7
These next steps can provide important insights into neuro-pathologies, ranging from #psychiatric, #developmental, to #degenerative. 6/7
#neuroscience #brainhealth
#neuroscience #brainhealth
Read how they found "Adult brain neurons require continual expression of the schizophrenia-risk gene Tcf4 for structural & functional integrity": rdcu.be/cy8pz
@DipannitaSark15 @Shariq73901065 @hiyaa_ghosh @Deepanjali25 @bhalla_lab
#openaccess #neuroscience #brain
@DipannitaSark15 @Shariq73901065 @hiyaa_ghosh @Deepanjali25 @bhalla_lab
#openaccess #neuroscience #brain
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