Jake died last May, presumably from taking a Xanax mimic containing fentanyl, the family released yesterday. This tragic death is sure to shed light on the growing problem of "fake pills," so here's everything you need to know about them. A 🧵. si.com/college/2021/1…
"Fake pills" have been around for a long time, but they received national attention in late 2015, when several people in SanFransisco died after taking Xanax bars purchased off the street. They were not alprazolam, but contained fentanyl, instead. cbsnews.com/news/fake-xana…
Much like bootleg Gucci bags, there's some terminology here regarding these knockoff pills:
Counterfeit - looks real, has the actual drug
Fake - looks real, has no drug
Mimic - Looks real, has other drugs
The most common mimic is Xanax bars and oxycodone pills. Almost all these contain fentanyl instead of alprazolam and oxycodone, respectively.
Where does fentanyl come from? Mostly from overseas labs, like in China. Labs can make *TON* quantities of fentanyl quick and cheap.
It is so much cheaper to make fentanyl than to grow a field of opium poppy, harvest it, transform the latex into heroin, and ship it. So much cheaper. We are literally flooded with fentanyl.
How flooded? The FedEx hub in Memphis receives 35K packages a day from China! In 2017, they seized 552 kg of fentanyl. For scale, that's 552 million 1 mg doses of fentanyl. And imagine what they *didn't* catch.
How does this relate to pills? Also in Memphis, agents raided a house that had three commercial pill presses, capable of spewing out 56K pills per hour! Here's 4935 M30 oxycodone mimics...all with fentanyl.
Some mimics look legit, others look janky. Here's generic pharmaceutical oxycodone and a mimic. You can probably guess which is which. So why mimic oxycodone? Purdue pharma created a huge demand and addicted millions. Legit oxy sells for ~$1/mg, so a 30 mg pill sells for $30!
Like with any drug on the street, you don't know what you're getting. Here's an extreme example (a slide from a death investigation talk of mine) that contained 20 different drugs! Why so many? I dunno, it's a witch's brew.
So do people know they aren't getting the "real deal" when they buy pills? Just like every user should know by now that "heroin" is really fentanyl, most *should* know that these pills aren't what they pretend to be. Should, but young college kids? Probably not.
It's a huge and growing problem, not just in the United States, but around the world. In the US it's fueled by our shoddy health care system, corporate greed that addicted millions, and antiquated drug laws. Pill mimics have killed thousands (maybe tens of?).
As a reminder, this is how Prince died - from a Vicodin (hydrocodone) mimic that was really fentanyl, and much, much more potent. nbcnews.com/news/us-news/n…
Nothing much came from Prince's death, but I have a feeling politicians, particularly from Texas where Jake and his brother Sam (now a QB with the Indianapolis Colts) are immensely popular, will speak out about the pill problem. I'll let you figure out why.
Did Prince know he was taking fentanyl? I dunno. Did Jake know he was taking fentanyl? I dunno, and neither you nor I should speculate on either. Just know that these deaths could have been prevented.
The end.
Happy Friday and enjoy your weekend!
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A toxicologist's take on the ONLY MURDERS IN THE BUILDING finale.
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SPOILER ALERT
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SPOILER ALERT
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YOU'VE BEEN WARNED
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Let's dive into the murder and poisoning of Tim Kono, and other things, a 🧵:
Tim Kono's autopsy report revealed the immediate cause of death was acute secobarbital poisoning. So what's secobarbital? It's a barbiturate, a class of drugs used for anxiety, as a sleep aid, and for seizures. They are widely called "sedative-hypnotics" because they....sedate.
So far, so good. Jan poisons Tim with secobarbital and we see Tim become drowsy, confused, and unable to move freely. This generally fits with secobarbital overdoses and toxicity and mimics what you might expect from alcohol intoxication.
Here's something fun and different for Toxicology Thursday: a self-guided poison plant tour at @ncartmuseum. Admittedly, it's centered around Raleigh-Durham folks, but these plants can be found throughout the southeast and other parts of North America. [link to PDF at the end]
Starting at the main lot, we'll walk down into the open clearing to find POKEWEED. The berries are poisonous and will stain your hands. Mature plants are poisonous too, but small young ones used to be sold in cans.
You'll also find (unless the groundskeepers recently mowed over everything) CAROLINA HORSENETTLE. It's like a tiny, prickly tomato, but it's not edible. All parts contain solanine and are toxic.
It's Thursday and time for toxicology, so enough politics, let's talk poisons (I think I need this more than you!). Today it's all about one of our favorite condiments, HORERADISH. It may seem simple, but its pungency is due to a binary weapon!
So that's horseradish growing in my garden, in case you were wondering where it actually came from. It goes amazingly well and the young leaves are edible - they add a nice little kick to a sandwich.
But horseradish sauce doesn't come from leaves, it's made from horseradish roots, like these that I harvested:
Happy Thanksgiving to those of you in the US! Happy Thursday to the rest of y'all.
I told you these were coming during my #amwriting breaks! In the spirit of overeating and edible things, here's the toxic tale of COPRINE.
The inkcap mushrooms, or "inky caps", are edible mushrooms with a mild flavor. I know, you're here for the poisonous mushrooms, not the edible ones. It is edible, but not when you consume them with alcohol! Weird, I know, but I'll explain. [pic by Nick Saltmarsh (CC BY-2.0)]
The ink caps contain a chemical called COPRINE. It's not too special, though the cyclopropyl group (the triangle part) is always fun to see in natural products. The problem with COPRINE is when it is metabolized. When ingested, the body breaks it down to AMINOCYCLOPROPANOL.
As promised, more toxic tales as I take a break from #amwriting. What I love about poisons is where it takes you: chemistry, biology, history... maybe the ED or a shallow grave.
Today we'll talk about the neurotoxic, hiccup-inducing, destroyer of kidneys CARAMBOXIN.
Caramboxin is found in starfruit, the fruit that is, uh, shaped like stars. It grows throughout Southeast Asia and tastes like a citrusy apple to me. It's a unique flavor and I rather like it. [pic by Ting W. Chang (CC BY-2.0)]
But you don't want to eat too much of it. I already spoiled it - I'm rightfully accused of being too "telly" in my writing - because of caramboxin.
Caramboxin is a non-proteinogenic amino acid - it's not encoded into our DNA or needed for anything. It's strictly a poison.
I have the rest of the week off, so when I take a break from #amwriting, expect a bunch of these.
You've heard of capsaicin, right? The the "hot" chemical in chili peppers? Today I present you with RESINIFERATOXIN. It's 🔥🔥🔥!
The resin spurge plant, Euphorbia resinifera is a cactus-y type thing found in north Africa. If you cut it open, it exudes a milky latex that contains resiniferatoxin. But watch out! [Pic by James Steakley (CC BY-SA 3.0)]
Resiniferatoxin is about 1000-times "hotter" than capsaicin. It's likely the hottest, most painful toxin on the planet, so I advise not putting it in your chili or making a hot sauce out of it.