Covid reinfection | #LongCovid
Long-term immune profiling of renal transplant patient | infected with SARS-CoV-2 a second time and hospitalized ~233 days after first infection
Neutralizing antibodies and humoral memory response level insufficient
🧵
academic.oup.com/jid/advance-ar…
Long-term immune profiling of renal transplant patient | infected with SARS-CoV-2 a second time and hospitalized ~233 days after first infection
Neutralizing antibodies and humoral memory response level insufficient
🧵
academic.oup.com/jid/advance-ar…
66 ys old man | renal transplant recipient | first infection: March 2020 | analysis of viral genetic strains from 2 infections shows distinct lineages, but without apparent immune escape capacity | immune response by patient potentially below threshold to prevent reinfection
Development of poorly neutralizing antibodies maybe linked to abnormalities in naive CD4 T-cell pools | seroconversion alone may not protect from reinfection in immunocompromised patients ❗| specific immune features seen here possibly linked to this person's status
Cytokine + other immunological analysis from first infection, too, showed immunological dysfunction and inflammation | this persisted even after covid symptoms improved
The study was carried out by @VirusesImmunity et al
I add here 🔽 a link to Prof Iwasaki 🧵 on the case study, with more information
I add here 🔽 a link to Prof Iwasaki 🧵 on the case study, with more information
https://twitter.com/VirusesImmunity/status/1454795445130219520?t=hGSpnBjLvgF_5SjVeYaZLw&s=19
Prof Iwasaki provided deeper insights into the case study and the immunological processes of SARS-CoV-2 re infection in this 🧵🔽
when the paper was published first as a pre-print
when the paper was published first as a pre-print
https://twitter.com/VirusesImmunity/status/1375555971964137478?t=v4Z_QYsxCOtsmOoIDj-Azw&s=19
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