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Dr Elisa Perego Profile picture
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30 Oct, 4 tweets, 4 min read
Working or job loss with #LongCovid

Many complex experiences, some very good points in 🧵 🔽

But also clear evidence of the potentially massive impact of SARS-CoV-2 infection on the workforce. Many will be unable to work again or will need long-term sick leave

#LongCovidWork
I add to this @patientled @itsbodypolitic research survey in a tweet by @ahandvanish

The majority of #LongCovid patients in their survey were unable to work ~7 months in. We've increasing evidence many don't recover beyond

Paper now in @EClinicalMed

Unable to work at all or maintain a full schedule to be more precise: 68%
Further attention on #LongCovidWork in a tweet from @LongCovidSOS

Many with #LongCovid are unable to work full time or return to their previous schedule or tasks

This is a disaster in the making

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More from @elisaperego78

Dr Elisa Perego Profile picture
31 Oct
Covid reinfection | #LongCovid

Long-term immune profiling of renal transplant patient | infected with SARS-CoV-2 a second time and hospitalized ~233 days after first infection

Neutralizing antibodies and humoral memory response level insufficient

🧵

academic.oup.com/jid/advance-ar…
66 ys old man | renal transplant recipient | first infection: March 2020 | analysis of viral genetic strains from 2 infections shows distinct lineages, but without apparent immune escape capacity | immune response by patient potentially below threshold to prevent reinfection
Development of poorly neutralizing antibodies maybe linked to abnormalities in naive CD4 T-cell pools | seroconversion alone may not protect from reinfection in immunocompromised patients ❗| specific immune features seen here possibly linked to this person's status
Read 6 tweets
Dr Elisa Perego Profile picture
30 Oct
Healthcare in the city of Trieste, northeast Italy, is under great strain. No vax demonstrations last week drove a SARS-CoV-2 spread

People with covid pneumonia are waiting at the emergency in a key city hospital: no beds available anymore

corriere.it/cronache/21_ot…
Trieste, northeast Italy, is now the province with one of the highest covid incidences in Italy.

The region of Friuli Venezia Giulia there has a lower vaccination rate than other regions in Italy. Unsafe vax demonstrations are driving SARS-CoV-2 spread

amp24.ilsole24ore.com/pagina/AEZGITt
The Maggiore Hospital in Trieste has now opened a new covid ward to host patients with moderate covid.

Patients are already flowing in from strained emergency departments in Trieste and other cities in the Friul region, like Gorizia

rainews.it/tgr/fvg/artico…
Read 4 tweets
Dr Elisa Perego Profile picture
29 Oct
I'm disappointed by this statement from a number of medical associations in the UK in response to the @NICEComms publication of the new #MECFS guidelines

I've concerns, in particular, about the view of chronic diseases reflected in the statement 🧵

rcplondon.ac.uk/news/medical-l…
A first concern regards the full scope of clinical guidelines for a severe (post) infection disease like #MECFS: growing research on viral/other onset diseases reveals a multi-system, complex pathophysiology
You can't cure this with exercise or psychological therapy (CBT)
We really need the full extent of biomedical research on viral-onset and related diseases to be taken into consideration. Patients need appropriate treatment and support, not poor quality intervention that don't address a complex pathophysiology with severe symptoms

#MECFS
Read 7 tweets
Dr Elisa Perego Profile picture
28 Oct
#LongCovid and sleep disruption.💤🛏 🧵
An area to address with urgency, both in terms of quality of life and as evidence of deeper health issues.
A percentage of patients may reveal sleep patterns indicative of long term neurodegenerative disease, a new study reveals 🔽
For the sleep study in question: a small sample (n=11 patients) mostly men (n=9 patients)
To note: relatively young age (52 years +/- 11 years)
Based on a follow up 60 days after covid diagnosis
64% of patients presented breathing complications

#LongCovid
#LongCovid patients have been reporting sleep problems for long. Sleep disruption is a documented long term effect of SARS-CoV-2 infection in numerous clinical studies.
Sleep problems are significant clinical issues that have often been poorly addressed in primary care and beyond
Read 4 tweets
Dr Elisa Perego Profile picture
15 Oct
Important summary of covid pathology in the lung from newly published tissue biopsies.
Note the truly astounding devastation from SARS-CoV-2 in fatal disease, including clotting.
I add a few points on how paper can be relevant to #LongCovid and non-critical patients 🧵
👉 covid pneumonia can be asymptomatic/ pauci-symptomatic e.g. paper attached 🔽
🔥 phenomena as those found in critical patients, but on a lesser scale, can thus affect non-hospitalized/ "mild" patients . Long term lung damage can be there

#LongCovid

pubmed.ncbi.nlm.nih.gov/32216718/
👉 imaging techniques like the SPECT scan *do* reveal long term lung damage in #LongCovid 🔽
🔥 in view of potential, significant lung damage even in "mild" patients, it's key to stop discussing symptoms like breathing difficulty as "anxiety" and the like
pubmed.ncbi.nlm.nih.gov/34339624/
Read 5 tweets
Dr Elisa Perego Profile picture
13 Oct
In the wake of increasing recognition of failed pandemic responses worldwide, like in the UK

Let's always remember that many early covid patients from Wuhan weren't "old and sick"

This was already clear from January 2020 data in @TheLancet

#LongCovid

thelancet.com/journals/lance…
This evidence of early known clinical evidence from Wuhan is especially damning for ideologies like the Great Barrington Declaration, which posited, erroneously, that SARS-CoV-2 infection is not that dangerous in the young. This was already patently not the case in January 2020
#LongCovid and #LongCovidKids are the nail in the coffin of public health "measures" and ideologies that encouraged to let SARS-CoV-2 rip through the population.
SARS-CoV-2 is virus with high mortality, but an even more egregious morbidity rate i.e. long term damage
Read 4 tweets

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