Trieste, northeast Italy, is now the province with one of the highest covid incidences in Italy.
The region of Friuli Venezia Giulia there has a lower vaccination rate than other regions in Italy. Unsafe vax demonstrations are driving SARS-CoV-2 spread
66 ys old man | renal transplant recipient | first infection: March 2020 | analysis of viral genetic strains from 2 infections shows distinct lineages, but without apparent immune escape capacity | immune response by patient potentially below threshold to prevent reinfection
Development of poorly neutralizing antibodies maybe linked to abnormalities in naive CD4 T-cell pools | seroconversion alone may not protect from reinfection in immunocompromised patients ❗| specific immune features seen here possibly linked to this person's status
Many complex experiences, some very good points in 🧵 🔽
But also clear evidence of the potentially massive impact of SARS-CoV-2 infection on the workforce. Many will be unable to work again or will need long-term sick leave
I'm disappointed by this statement from a number of medical associations in the UK in response to the @NICEComms publication of the new #MECFS guidelines
I've concerns, in particular, about the view of chronic diseases reflected in the statement 🧵
A first concern regards the full scope of clinical guidelines for a severe (post) infection disease like #MECFS: growing research on viral/other onset diseases reveals a multi-system, complex pathophysiology
You can't cure this with exercise or psychological therapy (CBT)
We really need the full extent of biomedical research on viral-onset and related diseases to be taken into consideration. Patients need appropriate treatment and support, not poor quality intervention that don't address a complex pathophysiology with severe symptoms
#LongCovid and sleep disruption.💤🛏 🧵
An area to address with urgency, both in terms of quality of life and as evidence of deeper health issues.
A percentage of patients may reveal sleep patterns indicative of long term neurodegenerative disease, a new study reveals 🔽
For the sleep study in question: a small sample (n=11 patients) mostly men (n=9 patients)
To note: relatively young age (52 years +/- 11 years)
Based on a follow up 60 days after covid diagnosis
64% of patients presented breathing complications
#LongCovid patients have been reporting sleep problems for long. Sleep disruption is a documented long term effect of SARS-CoV-2 infection in numerous clinical studies.
Sleep problems are significant clinical issues that have often been poorly addressed in primary care and beyond
Important summary of covid pathology in the lung from newly published tissue biopsies.
Note the truly astounding devastation from SARS-CoV-2 in fatal disease, including clotting.
I add a few points on how paper can be relevant to #LongCovid and non-critical patients 🧵
👉 covid pneumonia can be asymptomatic/ pauci-symptomatic e.g. paper attached 🔽
🔥 phenomena as those found in critical patients, but on a lesser scale, can thus affect non-hospitalized/ "mild" patients . Long term lung damage can be there
👉 imaging techniques like the SPECT scan *do* reveal long term lung damage in #LongCovid 🔽
🔥 in view of potential, significant lung damage even in "mild" patients, it's key to stop discussing symptoms like breathing difficulty as "anxiety" and the like pubmed.ncbi.nlm.nih.gov/34339624/
This evidence of early known clinical evidence from Wuhan is especially damning for ideologies like the Great Barrington Declaration, which posited, erroneously, that SARS-CoV-2 infection is not that dangerous in the young. This was already patently not the case in January 2020
#LongCovid and #LongCovidKids are the nail in the coffin of public health "measures" and ideologies that encouraged to let SARS-CoV-2 rip through the population.
SARS-CoV-2 is virus with high mortality, but an even more egregious morbidity rate i.e. long term damage