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@epigiri

30 Oct

Sudden cardiac arrest & Sudden cardiac death (SCD) refer to the sudden cessation of cardiac activity with hemodynamic collapse, typically due to sustained ventricular tachycardia/ventricular fibrillation; mostly occur in patients with previously undiagnosed diseaes.
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Results from Framingham heart study suggests that more men are affected with increasing age.
Not rare, 15 percent of the total mortality in the United States & other developed nations is due to SCD. (pubmed.ncbi.nlm.nih.gov/11684624/)

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-It is the initial clinical manifestation of 15% of coronary heart diseases (CHD).
-SCD is the mechanism of death in over 60% of patients with known CHD.
-Risk increases by a number of factors: Age, underlying cardiac diseases, post-menopausal women, CHD risk factors
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@epigiri

12 Aug

@DHFWKA

This tweet thread is about the results from the second serosurvey done in the #Karnataka state. Ahead of sharing the link, some caveats first.
1. The @DHFWKA has used the data from this round of serosurvey in late March to update testing and surveillance strategies.

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2. The study found Lower levels of IgG seroprevalence, mostly due to antibody waning.
3. A substudy was done to confirm the antibody waning. This study was delayed due to rapid surge of cases in April.
4. We found near 0 prevalence of active cases during mid-February 2021.
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5. There was a subsequent surge seen in Karnataka state due to a mix of alpha, delta which was picking up speed in April, and a large susceptible population were infected.
6. Results from the substudy on antibody waning was necessary for releasing the final report & paper.
3/n

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@epigiri

2 Aug

Polio anywhere could be a threat to countries that had eradicated it. It took decades to eradicate polio in most parts while some are yet to eradicate. Not just this necessity, it was possible mostly due to a collaborative approach & strong leadership at the global level.
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Lessons from Polio Eradiation, Cochi S et al
-Strong political & social support in each country
-Strategic planning & policy development
-Partnership management & donor coordination
-Program operations & tactics
-Oversight and independent monitoring.

polioeradication.org/wp-content/upl…

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If there was high polio circulation in one region, other countries could prevent the possibilities of its import by vaccinating the children in their countreis. Therefore, all countries are continuing polio vaccination till other regions accomplish eradication.

3/N

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@epigiri

31 Jul

One and half years without school is a great toll on the children. The difficult part is to answer how to reopen schools with strict enforcement of #COVID appropriate behaviours. How can schools be made safe and protected bubbles for children?

School transmission varies according to student age and incidence in the local areas. The outbreaks in the school settings are substantially reduced with mitigation measures. Regular testing, teacher and staff vaccination can help reduce transmission.
acpjournals.org/doi/full/10.73…

As per the ECDC, there is very little possibility that schools are not associated with accelerating community transmission.
ecdc.europa.eu/en/publication…

However, large outbreaks can occur within 2 weeks of school reopening as per this Israel study.
eurosurveillance.org/content/10.280…

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@epigiri

6 Jun

@jeevanrakshaa

Source: @jeevanrakshaa @Mysore_Sanjeev

The 7-Day Moving Growth Rate
-#Mumbai: < 2% for over 4 weeks, city ready phase 4?

-#Delhi & #Ahmedabad: <2% for 2 weeks.Phase 2 or 3?

-#Bengaluru, #Chennai & #Kolkata: little over 2% Phase 1?

Phases 1-4:

https://twitter.com/epigiri/status/1401469425836978183?s=20

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Case Fatality Rate (CFR) is increasing.
Why?
CFR= # Deaths / # Positive cases
- ↑ in numerator: Poor detection and treatment --> higher deaths
- Low Denominator ↓: Under-reporting of COVID Cases due to poor testing.

Higher the CFR in the city, poorer the TTT strategy.

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The review of positive Cases, active Cases, and death moving growth rate in juxtaposition will give wholistic view on the situation.
#Bengaluru & #Delhi have some work to do.

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@epigiri

6 Jun

Once test positivity is under 5 over a week, what's safe to #unlock in the first phase ?

In Phase-2, what's safe to #unlock?
No more than 10 people in the following settings.

In Phase-3, what is safe to #unlock?
Not more than 50% of the capacity

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