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30 Oct, 20 tweets, 5 min read
Sudden cardiac arrest & Sudden cardiac death (SCD) refer to the sudden cessation of cardiac activity with hemodynamic collapse, typically due to sustained ventricular tachycardia/ventricular fibrillation; mostly occur in patients with previously undiagnosed diseaes.
1 of N
Results from Framingham heart study suggests that more men are affected with increasing age.
Not rare, 15 percent of the total mortality in the United States & other developed nations is due to SCD. (pubmed.ncbi.nlm.nih.gov/11684624/)

2 of N https://www.sciencedirect.com/science/article/pii/S000287039
-It is the initial clinical manifestation of 15% of coronary heart diseases (CHD).
-SCD is the mechanism of death in over 60% of patients with known CHD.
-Risk increases by a number of factors: Age, underlying cardiac diseases, post-menopausal women, CHD risk factors
3 of N
The risk increases
-6- to 10 fold with heart disease
-2- to 4 fold with risk factors modifiable by specific preventive measures.

To reduce the risk of death,
- regular health checkups for heart disease
- Adopt better and healthy lifestyle (next)

4 of N
2/3rd of CHD is from tobacco, unhealthy diet & physical inactivity
9 risk factors
1. Smoking
2. Dyslipidemia
3. Hypertension
4. Diabetes
5. Abdominal obesity
6. Psychosocial factors
7. Diet
8. Regular alcohol consumption
9. Physical inactivity
sciencedirect.com/science/articl…
5ofN
Exercise —
-Regular exercise is associated with a lower resting heart rate and increased heart rate variability and reduced risk of SCD.
-The small transient increase in risk during exercise is outweighed by a reduction in the risk of SCA at other times.
6 of N
Risk of sudden cardia arrest (SCA) is transiently increased during and up to 30 minutes after strenuous exercise compared to other times. The actual risk during any one episode of vigorous exercise is very low (1 per 1.51 million episodes of exercise) .
7 of N
Do not stigmatize exercises and physical activity. -Magnitude of the transient increase in risk during acute exercise is lower among men who are regular exercisers compared with men for whom exercise is unusual.
8 of N
The lower overall risk associated with intensive exercise occurs in patients with certain, often unrecognized underlying heart diseases. (Hypertrophic cardiomyopathy, myocarditis & Arrhythmogenic right ventricular cardiomyopathy) Let the cardiologists decide and treat
9 of N
At the population level, there are two approaches to reduce the risk of SCA.
- Reduce SCA risk in every person: smoking cessation & other lifestyle modifications.
-Screening & risk stratification to identify individuals who may benefit from clinical treatment.

10 of N
There is strong advocacy, communication and services available for screening and risk stratification in persons who can afford or have health insurance. Since cardiac surgeries are covered under PMJAY an state health programs, there are efforts to utilize by hospitals.
11 of N
It is time primordial, primary & secondary prevention of heart diseases and related deaths take the centre stage of health services.
-Primoridial to is to get rid of risk factors.
-Primary prevention involves preventing the onset of disease in those who have risk factors.
12 ofN
Secondary is to ensure people with diseases get adequate and timely treatment to prevent deaths or complications.
- 1 in 3 adults have high blood pressure
- 1 in 10 adults have T2 diabetes mellitus.
Nearly 50% of them are not diagnosed & present with complications/death.
13 ofN
To help yourself and others, assess risk factors, seek or provide help. For example, inform those who use: smoking even 1 cigarette per day is associated with approximately 50% increased risk for CHD and approximately 25% increased risk for stroke.
pubmed.ncbi.nlm.nih.gov/29367388/
14 of N
On whom to screen?
Advanced obstructive coronary heart disease (CHD) can exist with minimal or no symptoms, with manifestations that can progress suddenly, often associated with significant morbidity and/or mortality.
Should everyone get screened? see next
15 of N
Screening with additional tests is appropriate for persons in certain high-risk occupations (eg, pilots, bus drivers) where an acute cardiac event could endanger large numbers of people, or for individuals with higher risk of CHD or those starting intensive exercises.
16 of N
Rationale for screening & detection of CHD during subclinical stages of disease is hope that appropriate treatment (medical or coronary revascularization) may improve prognosis. However, limited evidence that such screening actually improves outcomes at population level.
17 of N
Screening and taking actions are recommended to prevent sudden cardiac death in athletes and those who engage in strenuos, high intensity exercise schedule. It
Refert to Recommendations and Considerations here: ahajournals.org/doi/full/10.11…

18 of N
Screening should include a complete personal, family history, physical examination in all athletes of any age. Performing a screening ECG in athletes and exercise stress test in athletes age 35 years or older is recommended and should be repeated at periodic intervals.
19 of N
For all those who are concerned about sudden cardiac deaths, please refer to #uptodate for evidence based recommendations.

uptodate.com/contents/scree…

uptodate.com/contents/overv…

Do not heed to any uninformed advice on social media. Stop #misinformation.

20 of 20

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More from @epigiri

12 Aug
This tweet thread is about the results from the second serosurvey done in the #Karnataka state. Ahead of sharing the link, some caveats first.
1. The @DHFWKA has used the data from this round of serosurvey in late March to update testing and surveillance strategies.

1 of N
2. The study found Lower levels of IgG seroprevalence, mostly due to antibody waning.
3. A substudy was done to confirm the antibody waning. This study was delayed due to rapid surge of cases in April.
4. We found near 0 prevalence of active cases during mid-February 2021.
2/n
5. There was a subsequent surge seen in Karnataka state due to a mix of alpha, delta which was picking up speed in April, and a large susceptible population were infected.
6. Results from the substudy on antibody waning was necessary for releasing the final report & paper.
3/n
Read 8 tweets
2 Aug
Polio anywhere could be a threat to countries that had eradicated it. It took decades to eradicate polio in most parts while some are yet to eradicate. Not just this necessity, it was possible mostly due to a collaborative approach & strong leadership at the global level.
1/N
Lessons from Polio Eradiation, Cochi S et al
-Strong political & social support in each country
-Strategic planning & policy development
-Partnership management & donor coordination
-Program operations & tactics
-Oversight and independent monitoring.

polioeradication.org/wp-content/upl…

2/N
If there was high polio circulation in one region, other countries could prevent the possibilities of its import by vaccinating the children in their countreis. Therefore, all countries are continuing polio vaccination till other regions accomplish eradication.

3/N
Read 11 tweets
31 Jul
One and half years without school is a great toll on the children. The difficult part is to answer how to reopen schools with strict enforcement of #COVID appropriate behaviours. How can schools be made safe and protected bubbles for children?
School transmission varies according to student age and incidence in the local areas. The outbreaks in the school settings are substantially reduced with mitigation measures. Regular testing, teacher and staff vaccination can help reduce transmission.
acpjournals.org/doi/full/10.73…
As per the ECDC, there is very little possibility that schools are not associated with accelerating community transmission.
ecdc.europa.eu/en/publication…

However, large outbreaks can occur within 2 weeks of school reopening as per this Israel study.
eurosurveillance.org/content/10.280…
Read 5 tweets
6 Jun
Source: @jeevanrakshaa @Mysore_Sanjeev

The 7-Day Moving Growth Rate
-#Mumbai: < 2% for over 4 weeks, city ready phase 4?

-#Delhi & #Ahmedabad: <2% for 2 weeks.Phase 2 or 3?

-#Bengaluru, #Chennai & #Kolkata: little over 2% Phase 1?

Phases 1-4:

1ofN
Case Fatality Rate (CFR) is increasing.
Why?
CFR= # Deaths / # Positive cases
- ↑ in numerator: Poor detection and treatment --> higher deaths
- Low Denominator ↓: Under-reporting of COVID Cases due to poor testing.

Higher the CFR in the city, poorer the TTT strategy.

2ofN
The review of positive Cases, active Cases, and death moving growth rate in juxtaposition will give wholistic view on the situation.
#Bengaluru & #Delhi have some work to do.

3 of N
Read 7 tweets
6 Jun
Once test positivity is under 5 over a week, what's safe to #unlock in the first phase ?
In Phase-2, what's safe to #unlock?
No more than 10 people in the following settings.
In Phase-3, what is safe to #unlock?
Not more than 50% of the capacity
Read 4 tweets
4 Jun
Not just that the technology is a barrier, this is the first time that India uses anything as a mandatory requirement for getting vaccinated. #CowinApp
Nothing can be a prerequisite for getting vaccinated or getting tested. #VaccineForAll
"It is easier to get married in India than to get vaccinated"

- @Dr_Aqsa_Shaikh , MBBS, MD Community Medicine is an Associate Professor of Community Medicine at Hamdard Institute of Medical Science and Research, Jamia Hamdard, Delhi.

Read 4 tweets

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