UPDATE: 5x COVID hospitalizations increase ⬆️ in 2 weeks in Gauteng Province 🇿🇦, #Omicron epicenter. This is an increase from 3x over the weekend (for same 2 week period). Partial report of latest week also suggests hospitalizations are accelerating. 🧵 #COVID19 (from @nicd_sa)
2) first noticed this worrisome trend on Sunday. It’s grown from ~400 to now 647 with updated hospital admissions numbers.
REINFECTION RISK—New #Omicron study finds huge surge in #COVID19 **reinfections**. Worse, relative to old waves—➡️ huge numbers of infections in new Omicron wave are reinfections. How much? 📍2.4x higher reinfection risk with Omicron. 🧵 HT @SACEMAdirector medrxiv.org/content/10.110…
2) Not just merely a 2nd infection — is possible to also get a **THIRD INFECTION** with #COVID19. Let’s look at this graph - many people got a third infection recently too in the #omicron wave. 👇
3) There has been 332 people in South Africa 🇿🇦 documented with a 3rd infection (aka a two reinfections). And 35k with one reinfection.
BREAKING—New domestic-travel only #Omicron case identified in Minnesota of a travelers who visited New York City and attended an anime convention at the Javits Center Nov 19-21, and got symptoms on Nov 22nd. ➡️With such timeline, it could be now across US. content.govdelivery.com/accounts/MNMDH…
2) This one is more significant than the SF case yesterday because SF #Omicron had South Africa travel. This MN case had only domestic travel. And Nov 19-21 in NYC dates it before the variant was discovered and reported for the first time by South African authorities! 👀
(Whisper) ummm… a new subvariant of #Omicron has now been spotted with **P681R** spike mutation instead of P681H. The “681R” amino acid mutation is a key “bad” mutation that made Delta ⬆️more infectious. Most Omicron samples didn’t have it before➡️ now 1 has acquired it. 👀
FASTEST SURGE TO DATE—The #OmicronVarient is up swinging much faster in both new daily cases and positivity, than all previous waves in South Africa 🇿🇦, according to @nicd_sa data illustrated by @jburnmurdoch. This supports the faster transmission theory of #Omicron. 🧵
2) and the upswing in South Africa is not just localized to one area. It’s seen across most provinces together. That a bad sign too.
A rise in possible #Omicron in England—tripling (0.1 to 0.3) of S-Gene dropout PCR signal, which is a proxy for Omicron (before 🧬 sequencing confirms). @_nickdavies estimates this represents around ~60 cases in 🏴. Still early—but it displacing #DeltaVariant is not good sign. 🧵
2) I again stress it’s early, but it’s a signal to watch. @_nickdavies notes these PCR signals all in the last 5 days.