FASTEST SURGE TO DATE—The #OmicronVarient is up swinging much faster in both new daily cases and positivity, than all previous waves in South Africa 🇿🇦, according to @nicd_sa data illustrated by @jburnmurdoch. This supports the faster transmission theory of #Omicron. 🧵
2) and the upswing in South Africa is not just localized to one area. It’s seen across most provinces together. That a bad sign too.
3) a small early upswing of probable #Omicron is likely happening in England too.
4) the only neutral news is that hospitalization rate is on pace with other waves. But this is a lagging indicator that is slow to report. But it doesn’t seem “milder” considering the 5x hospitalization increase in 2 weeks seen. Mortality data we have to still see.
5) Some say “but but but hospitalization tied, but cases faster means milder”… that’s not necessarily true. 🇿🇦 is now more heavily vaccinated than before. This would temper the rise in hospitalizations compared to earlier waves with less/no vaccines. John mentions this too.
6) #Omicron has hugely displaced Delta in South Africa 🇿🇦 . #B11529 Omicron now sits around~ 80% while both lineages of Delta are now low.

Figure by @Mike_Honey_
7) Ummmm… Ghana has entered the #Omicron chat. In Accra 🇬🇭, #B11529 has also massively displace both older Delta strains. Omicron is now also 80% there.

Figure by @Mike_Honey_
8) What is the latest in estimate relative growth rate (transmission) of #Omicron vs #Delta? 5.2x!

This confirms @JPWeiland’s 5x last week and yesterday’s 4.5x relative transmission advantage. THAT. IS. HUGE.
9) random thoughts of a virologist I trust…. don’t delude yourself that #Omicron will be mild on some BS anecdotal stuff. The real data doesn’t support that so far.
10) hospitalizations meanwhile up 5x in 2 weeks in GP 🇿🇦
11) based on modeling of the Rt values, @JPWeiland estimates #Omicron to be ~4.5x of #DeltaVariant (3.0/0.67)

Assuming no changes in mitigations - which the likely is in recent days — which would make Omicron even faster if it’s since been tempered by more new mitigation.
12) here is how fast #OmicronVariant wave is surging. Positivity now over 12% nationwide. It took just 50 days to hit what took 70-75 days for other waves.
13) What is partly explaining the surge? #Omicron has notable evasion against past immunity from past infections. Reinfections are soaring - 2.4x risk! See study below 👇
14) ACCELERATION— cases and hospitalizations continue to accelerate. If you look at the increase ⬆️ on a log scale… you can more easily identify the upswing in all the metrics.
15) And yes hospitalization is getting worse… notice that as time goes, more hospitalizations are backfilled. It’s getting worse if you follow the data daily. I’m not trying to sensationalize— but it’s the clear conclusion from the data.
16) Delayed hospitalization reporting…

👀 OBJECTS IN THE REARVIEW MIRROR MAY APPEAR SMALLER THAN THEY ARE!!! 👀

⚠️Bottomline hospitalizations are surging. Almost 10x rise in 2 weeks!

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More from @DrEricDing

3 Dec
⚠️KIDS HOSPITALIZATIONS—The “highly transmissible” #Omicron variant is putting disproportionately large numbers of children under the age of 5 years old in hospitals, a top South African government medical adviser said Friday. #COVID19 🧵
thedailybeast.com/omicron-varian… Image
2) “for example, that in the city of Tshwane Metro, more than 100 children under the age of 5 were admitted to hospitals with COVID in the first two weeks of the new fourth wave (Nov. 14 to 27). In the first two weeks in May 2021 wave, <20 children were admitted to hospitals.”
3) She said that with adults increasingly vaccinated, children are the ones who are “getting sick and need to be admitted.”

thedailybeast.com/omicron-varian…
Read 10 tweets
2 Dec
BREAKING—Five cases of the #Omicron variant have been confirmed in New York, Gov. Kathy Hochul says. This follows MN cases today that traveled to NYC recently. #COVID19
newyork.cbslocal.com/2021/12/02/5-c…
2) One case in MN— it took a long time over the holidays to find it.
3) NY meanwhile…. Stats not good regardless of variant.
Read 4 tweets
2 Dec
REINFECTION RISK—New #Omicron study finds huge surge in #COVID19 **reinfections**. Worse, relative to old waves—➡️ huge numbers of infections in new Omicron wave are reinfections. How much? 📍2.4x higher reinfection risk with Omicron. 🧵 HT @SACEMAdirector
medrxiv.org/content/10.110… Image
2) Not just merely a 2nd infection — is possible to also get a **THIRD INFECTION** with #COVID19. Let’s look at this graph - many people got a third infection recently too in the #omicron wave. 👇 Image
3) There has been 332 people in South Africa 🇿🇦 documented with a 3rd infection (aka a two reinfections). And 35k with one reinfection. Image
Read 10 tweets
2 Dec
BREAKING—New domestic-travel only #Omicron case identified in Minnesota of a travelers who visited New York City and attended an anime convention at the Javits Center Nov 19-21, and got symptoms on Nov 22nd. ➡️With such timeline, it could be now across US. content.govdelivery.com/accounts/MNMDH… Image
2) This one is more significant than the SF case yesterday because SF #Omicron had South Africa travel. This MN case had only domestic travel. And Nov 19-21 in NYC dates it before the variant was discovered and reported for the first time by South African authorities! 👀
3) Only a matter of time for more cases.
Read 12 tweets
2 Dec
A rise in possible #Omicron in England—tripling (0.1 to 0.3) of S-Gene dropout PCR signal, which is a proxy for Omicron (before 🧬 sequencing confirms). @_nickdavies estimates this represents around ~60 cases in 🏴󠁧󠁢󠁥󠁮󠁧󠁿. Still early—but it displacing #DeltaVariant is not good sign. 🧵
2) I again stress it’s early, but it’s a signal to watch. @_nickdavies notes these PCR signals all in the last 5 days.
3) to be clear, the “60” number is a excess number of SGTF beyond random lab error background levels.
Read 4 tweets
1 Dec
BREAKING—the @CDCgov has identified first case of the #Omicron variant in the US in California, via CNN source. #COVID19
2) we need initiate INTERNATIONAL arrivals testing + followup testing ASAP.
3) THIS. IS. DE. JA. VU. … feels like the the US is back in February 2020 all over again.
Read 9 tweets

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