Today is #WorldAidsDay2021
Sharing our new review on "Impact of Chronic HIV Infection on SARS-CoV-2 Infection, COVID-19 Disease and Vaccines” by @YYexin. A short thread (1/)
link.springer.com/article/10.100…
Sharing our new review on "Impact of Chronic HIV Infection on SARS-CoV-2 Infection, COVID-19 Disease and Vaccines” by @YYexin. A short thread (1/)
link.springer.com/article/10.100…
Despite a number of studies, whether HIV infected individuals are at higher risk of COVID-19 diagnosis, hospitalization, and mortality remains unclear due to variable results found in the population studies, cohort studies, and case series. (2/)
People with chronic HIV infection have distinct immune profiles, such as reduced IFN-I, chronic inflammation, CD4 ⬇️, CD8 exhaustion, poor B cell responses, which impair immune defense against SARS-CoV-2. (Beautiful figure 🎨 by @YYexin) (3/) 
Such immune impairments in HIV infected individuals make it possible for SARS-CoV-2 to replicate for an extended time period, accumulating mutations. (4/)
medrxiv.org/content/10.110…
medrxiv.org/content/10.110…
However, the good news is that current vaccines are well tolerated and still work well, albeit at lower efficacy, in HIV infected people in preventing infection and severe disease. We do not know the relative longevity of this protection in this population. (5/)
This reinforces the importance of vaccinating people in HIV endemic regions, to protect them from COVID and preventing emergence of new variants. Importance of #VaccineEquity cannot be overemphasized. (End)
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