Mia Malan Profile picture
Dec 3, 2021 16 tweets 9 min read Read on X
[Thread] @nicd_sa, Michelle Groome and Waasila Jassat:

1. SA's 7-day moving average of new daily #COVID19 cases has increased from 332 on 16 Nov to 4,814 on 1 Dec (particularly high increase over the last 2 days)
2. This increase is unprecedented (higher than in any other wave)
2. The most rapid increase in new #COVID cases has been seen in Gauteng (red line on left graph)
3. Test positivity rates are a good indication of how rapidly a virus is spreading. + rate = nr of tests coming out +.

Over the past week SA's test +rate for #COVID19 has increased from 1-2% to Thurday's 22.4%. Increases over the last 3 days have been particularly high.
4. Here you can see how + rates have increased in provinces. +rates in Gauteng (34%) and Limpopo (28%) are the highest.
5. This graph shows the test positivity rate among different age groups. Although more young people tested + initially in Oct/Nov, that is now moving into older age groups.
6. This table shows the reproductive (R) nr for provinces. It tells you how many people an infected person will infect. It's concerning when it's higher than 1.

All SA provinces have an R higher than 1. GP = 2.33.

This means each person in GP will infected more than 2 others.
7. What about hospital admissions?
1. Over the past 2 weeks, hospital admissions have increased across SA.
2. The highest increase has been in GP.
3. There have been small increases in NW, LP, MP, EC.
8. By how much have hospital admissions and deaths increased over the past 14 days?
1. The biggest hospital admission increases are in GP (304%), NW (65%) and LP (13%)
2. The biggest hospital death increases are in NW (140%), GP (17%) and EC (16%)
9. What's happening in Gauteng with #COVID19 cases in age groups?

Initially the largest group of people who tested positive = people between 10 and 29 years, but that is now extending to other age groups (outbreaks started @ universities, where 20-29 hangs out)
10. Hospital admissions in all districts in Gauteng are not starting to rise rapidly. There are steep week on week increases (blue line in graph = new #COVID19 cases; orange line = new COVID hospital admissions)
11. Gauteng has seen a significant increase in hospital admissions of kids of 5 and younger. Older people (60+) still constitute most new admissions, but kids of under 5 are now a much larger proportion of admissions than previously.
12. This graph compares hospital admissions in Tshwane (where the #OmicronVariant outbreak started) during the 3rd and 4th wave.

3rd wave: People of 50+ mostly got admitted
4th wave: People below 40 years are mostly getting admitted (look at the high nrs for 30-39 and 0-4 yrs)
13. Northwest: There is an increase in #COVID19 cases and hospital admissions in all districts

Limpopo: There is a small increase in hospital admissions in Vhembe, Capricorn and Waterberg districts
14. MP:
1. Small increases in #COVID19 hospital admissions in Ehlazeni and Nkangala
2. Increases in new #COVID19 cases across the province
15. EC: Increases in new #COVID19 cases and small increases in #COVID19 hospital admissions
FS: No increases in hospital admissions yet
16. Summary:
1. There is early evidence that the #OmicronVariant = more transmissible + poses an increased risk 4 reinfection
2. We don't know what Omicron's impact is on severe disease - cases are mild so far, but = takes time 2 fall very ill, so we need 2 wait for better data.

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More from @miamalan

Jul 24
🧵1. BREAKING: The peer-reviewed results of the study of a 6-monthly jab, #lenacapavir, in which not a single of the 2134 women between 16-25 years who received the jab contracted #HIV, were released at #Aids2024.

Find the full study here:

bhekisisa.org/wp-content/upl…
Image
2. Women often find it hard to adhere to daily #oralPrEP. In the Purpose 1 trial, 91.5% of women returned on time for their next #lenacapavir jab at 26 weeks and 92.8% at week 52. Image
3. Only 4 women out of 2134 (0.2%) who received #lenacapavir dropped out of the trial because of injection-site reactions. Image
Read 15 tweets
Jan 17
[Thread] 12 things to know about the the proportion of pregnant women infected with #HIV from SA’s latest antenatal HIV survey. The survey is conducted by the @nicd_sa.

(Analysis of our 95-95-95 goals in my next thread later in Jan).

1/12 Image
2. What is the antenatal #HIV survey?

1. It measures the % of HIV+ pregnant women between the ages of 15 + 49.
2. Only women using state pregnancy clinics take part.
3. The survey has been conducted each year between 1990-2015, then in 2017, 2019 +2022. Image
3. How many pregnant women between 15-49’s blood was tested for #HIV? 37 828 out of 40 542 collected samples.
- 37 7171 = Black African women
- 37 541 didn’t live with the dad of their child
- 35,635 of dads were 5 years+ older than moms (this makes them more likely to get HIV) Image
Read 12 tweets
Jan 10, 2023
JUST IN [Thread]:
1.@healthza's Lesley Broomberg:
An extra #COVID19 booster jab for people of 18+ in SA will become available towards the end of JANUARY
- People of 50+ qualify for a 5th dose
- People of 18+ qualify for a 4th dose
2. Lesley Broomberg: Can you mix and match with additional boosters? Yes. You can choose whether you want a #JnJ or #Pfizer booster.
3. Lesley Broomberg:
Will teens of 12-17 qualify for boosters? Not at this stage. Why not? The #VMAC = not recommended booster doses for 12-17, based on an understanding that the protection provided by 2 #Pfizer doses = adequate, as 12-17 = @ low risk of severe #COVID19 illness
Read 5 tweets
Jan 10, 2023
[Thread] #JoePhaahla:
- Genomic surveillance Network reported the detection of the new subvariant XBB.1.5 in SA of a sample of a patient tested on 22 Dec
- Details of the patient = not known, it was a random sample taken for testing
- XBB.1.5 = also common in US
2. XBB.1.5 = common in US
#JoePhaahla:
- 97%+ of #COVID19 cases worldwide = still #Omicron
- XBB.1.5 cases = no major change in hospitalisations or deaths
- Immunity of SAs (vax and natural immunity) = still strong, so that is why we haven't seen much change in terms of hospital admissions/deaths
Read 5 tweets
Dec 13, 2022
🧵1. SA's @aspenpharma will be making 4 jabs (fill + finish) — pneumococcal, rotavirus, meningococcal, hexavalent — from 2023.

How will they finance this?
With a $30 million grant from @CEPIvaccines + @gatesfoundation.

Which APIs will Aspen use?
India's Serum Institute's
2. Why is it NB that an African company makes these jabs?

#Africa imports almost all its jabs. #COVID19 showed us this results in Africa being last in line to get vaccines during pandemics. The grant to Aspen is 1 of the 1st steps to change that.
3. What's the goal?

By 2040, the African Union wants #Africa to make 60% of the jabs the continent uses.

Why?
So that Africa is better equipped 2 respond 2 outbreaks (by developing the ability to make jabs + have technology in place to also make new jabs during pandemics).
Read 6 tweets
Dec 2, 2022
🧵1. BREAKING: @SAHPRA1 has confirmed the registration of the #HIV prevention jab, #CABLA in South Africa. On Thursday, #ViiVHealthcare issued their statement. ImageImage
2. Who can use the jab? @SAHPRA1 didn't specify restrictions for use in their statement, only that it is "a highly effective option for people at substantial risk of #HIV infection." Image
3. How does the jab work? It uses an #ARV called cabotegravir that prevents #HIV from replicating and entering someone’s cells. It’s taken every two months. Read my latest story for more. bit.ly/3ER7ejq
Read 5 tweets

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