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Eric Feigl-Ding Profile picture
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15 Dec, 5 tweets, 3 min read
NEW—The new #Omicron variant can likely now infect RODENTS 🐁 — the coronavirus couldn’t bind 🐭 ACE2 receptor before… but looks like Omicron can now. I vote for elimination, because I don’t want forever #COVID19 or play whack-a-rat repeated waves of COVID.
2) To be clear, other variants theoretically can bind / infect, but at much lower likelihood. The new study now proves direct binding of Omicron to mouse 🐁 ACE2.
3) notice that other variants only weakly bound mouse 🐁 ACE2. But this study shows #Omicron binding mouse ACE2 is much much stronger than variants (red line in bottom panel), and now binds almost as strong as Omicron binding human ACE2. 👀
4) the same study also reports the most comprehensive vaccine study to date on neutralization results against #Omicron. There is good news and bad news 👇

8) more virus in the bronchus with #Omicron may explain why it’s so much more contagious.

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More from @DrEricDing

Eric Feigl-Ding Profile picture
16 Dec
The #Omicron variant is surging in the US exponentially… CDC data shows that New York / New Jersey region is now over 10% Omicron of all #COVID19 cases. The rest of US is not far behind—likely dominant by Christmas 🎄 — please be careful during holidays.

Figure by @DrWilliamKu. Image
2) I’m glad that NYC will be distributing free COVID tests and KN95 masks. Thank you @NYCHealthCommr @davechokshi!
3) NYC positivity has doubled in just 2 days. That’s bad bad bad. Image
Read 5 tweets
Eric Feigl-Ding Profile picture
15 Dec
📍The coronavirus is airborne. Very airborne. Even if you don’t see anyone—doesn’t mean the aerosols aren’t in the air. WATCH📺

➡️ you need high quality N95 / KN95 / KF94 / FFP2/ FFP3 masks.

➡️ also please ventilate, get HEPA filters, get upper room UV.
2) VENTILATION is key. Both ventilation and masks needed to reduce risk indoors. But most buildings not ventilated well enough.

3) AEROSOLS ARE AIRBORNE.

“Until we recognise that #COVID19 is airborne we are setting ourselves up for repeated failure”
Read 8 tweets
Eric Feigl-Ding Profile picture
15 Dec
💡New VACCINE RANKING of ability to neutralize #Omicron—Moderna appears to be the strongest against Omicron in this study, but still big drop. Pfizer next best (but we know infection efficacy is 30-34%), AstraZeneca & Sinopharm poor. J&J & Sputnik = zero.🧵biorxiv.org/content/10.110…
2) Natural infection immunity is on the left … “convalescent” = practically no neutralization against #Omicron in this study by itself without vaccine.
3) Meanwhile for SinoVac —one of the world’s most widely used vaccines, doesn’t provide sufficient antibodies to neutralize the #omicron variant, said 🇭🇰 researchers. But a 3rd shot booster seemed up help. bloomberg.com/news/articles/…
Read 13 tweets
Eric Feigl-Ding Profile picture
15 Dec
Don’t count on monoclonal antibody drugs to save you—German researchers have found that #COVID19 synthetic antibody therapies developed by Eli Lilly and Regeneron lose most of their effectiveness when exposed in laboratory tests to the #Omicron variant.
reuters.com/business/healt…
2) While many drugs work, I don’t think they will end the pandemic. Stopping transmission and opportunities for mutation will be what saves us in the end. Not just milder cases with expensive pharma treatment.
3) Many monoclonal antibody drugs are now in trouble against #Omicron
Read 5 tweets
Eric Feigl-Ding Profile picture
15 Dec
HIGHEST kids COVID hospitalization ever in England 🏴󠁧󠁢󠁥󠁮󠁧󠁿 of the whole pandemic… ➡️ But but but… I thought some politicians & economist had once said “kids are practically immune” to #COVID19. 🤦🏻‍♂️
2) Kids are known transmitters. They are not just like vaccinated adults. Kids are kids. Every hospitalization is a tragedy.
3) a 3 million person Danish study shows more kids in a household, more transmission. This is why we need to vaccinate to both protect kids and protect others in the household.
Read 10 tweets
Eric Feigl-Ding Profile picture
14 Dec
BREAKING—Largest study of 2-shot Pfizer vaccine effectiveness against #Omicron from largest health insurer in 🇿🇦:

📌33% VE against #Omicron (symptomatic?) infection

📌70% VE against #Omicron hospitalization (93% against #DeltaVariant before in 🇿🇦)

➡️Urgently need boosters.🧵
2) the new study also mentions 20% greater risk of hospitalization among kids with #Omicron compared to an older strain last year.
3) Also, the protective effects of prior infection has waned and further erode by #Omicron. ➡️ Bottomline: don’t rely on past infection immunity!
Read 13 tweets

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