BREAKING🎄 The 6th preprint from G2P-Japan - #Omicron is less infectious and pathogenic than #Delta and even an early pandemic SARS-CoV-2 in infected hamster model. 1/5 
How come?
We have recently reported that Delta spike is efficiently cleaved into two subunits, and therefore, Delta is highly fusogenic and highly pathogenic @Nature . 2/5
nature.com/articles/s4158…
We have recently reported that Delta spike is efficiently cleaved into two subunits, and therefore, Delta is highly fusogenic and highly pathogenic @Nature . 2/5
nature.com/articles/s4158…
In sharp contrast, Omicron is less fusogenic (left panel) and its spike is faintly cleaved (right panel). Our data suggest that the efficacy of spike protein cleavage, fusogenicity and pathogenicity are well correlated each other. 3/5
Moreover, our statistical analysis shows that Omicron is >3-5-fold more transmissible than Delta. 4/5
Our pre-preprint has been uploaded (free available from the URL below). It will be come out as a preprint (and hopefully a peer-reviewed paper) pretty soon.
And yes, we are G2P-Japan🇯🇵
Happy Xmas🎄 5/5
drive.google.com/file/d/1rhCazF…
And yes, we are G2P-Japan🇯🇵
Happy Xmas🎄 5/5
drive.google.com/file/d/1rhCazF…
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