Dear Pandemic Profile picture
Jan 27 17 tweets 8 min read
1/ Q: Are cases peaking? That means it’s all downhill from here, right?

A: Sort of…. Remember that even if cases come down as quickly as they rise, there will be as many cases *after* the peak as before (think area under the curve).

dearpandemic.org/are-cases-peak…
2/ ➡️ And if the downward slope is *slower* than the rise, we will see *more* cases during the decline from a surge.
3/ Burning fast could be a silver lining of super transmissible #Omicron. Cases rose & fell quickly in S. Africa (w/ hospitalizations & deaths still lagging). The UK appears to have turned the Omicron corner. Many US states appear past their peak in cases, w/ regional variation:
4/ When cases peak, it can feel like we are in the clear. It would be welcome news if Omicron falls as fast as it has risen. The Nerdy Girls are cheering on that “exponential decay”. But we do need to temper this feel-good moment with a bit of caution.
5/ Even on the ⬇️side of a steep peak 📉, there are A LOT of cases.

That feeling of everyone having COVID will likely stick around a bit longer. This means your chances of being exposed are still high, even if those chances are getting smaller rather than larger each day.
6/ We also need to be aware that the fall may *not* be as fast as the rise in cases. What starts as a decline can easily turn into a high plateau. The UK is a bit ahead of most of the US in its Omicron wave, but recent big declines are now leveling off at still high levels:
7/ This is reminiscent of the Delta wave in the UK which never really came down from its high plateau over the summer after some initial fall from the peak. Denmark is showing that a seeming decline in cases can swiftly turn around into an even higher peak.
8/ Where is it all going?

Like most public health scientists, we are completely done making predictions. This pandemic has humbled everyone.
9/ But the shape of the curve is not determined purely by nature- human behavior still plays an important role. w/o formal restrictions, UK mobility data showed that people voluntarily changed their behavior a lot & went out less as Omicron surged in Dec. ft.com/content/dea539…
10/ When cases go ⬆️ people step up their precautions such as masking or testing before gatherings. These small adaptations can add up big at the population level & slow the spread, contributing to getting past that ever-important peak. BUT—the opposite is also true.
11/ While getting past the peak is psychologically soothing, don’t use it as an excuse to kiss strangers and throw all caution to the wind.
12/ It’s natural to have an optimism bias—if cases are moving in the right direction, we feel comfortable relaxing some of our precautions. But relaxing too much can put us individually at risk while cases are still super high & put the brakes on that downhill momentum.
13/ As mentioned above, if the downward slope is slower than the rise, we will see *more* cases during the decline from a surge. More cases still mean more hospitalizations and deaths—and the U.S. is currently seeing more than 2000 COVID-19 deaths A DAY.
14/ In weighing up your own risk budget, keep an eye on absolute levels in your local area, not just whether cases are declining or not (spoiler alert-they are still high EVERYWHERE).
15/ We recognize that for many who are boosted or not high risk themselves, your daily decisions may not change much at all. On the other hand, the immunocompromised & those with kids in school may feel very vulnerable. scientificamerican.com/article/latest…
16/ If you are high risk, it’s worth holding steady a bit longer until that downhill slide of the curve gets even more momentum. As a bonus, the more people–high risk or not–who make those “tiny wise decisions” the faster & steeper that “exponential decay” will be.
17/ So that means that on the downhill is when we want to ….STEEPEN THE CURVE! 📉

Despite all the rhetoric, we still are in this together.

Love,
Those Nerdy Girls

#SteepenTheCurve #ExponentialDecay #AreaUndertheCurve #Omicron #TinyWiseDecisions

dearpandemic.org/are-cases-peak…

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More from @DearPandemic

Dec 30, 2021
1/ Q: Case numbers are jumping QUICK! What should I be doing?

A: Share your gifts without sharing COVID. Helpful gestures come in many shapes.

dearpandemic.org/what-should-i-…

#Omicron #ThoseNerdyGirls
2/ One HUGE help: Cancel non-essential plans.

Unfortunately, this includes New Year’s Eve plans. The perfect storm of a new variant & holiday get-togethers is hitting communities & health care w/ FORCE! Testing is in short supply.
3/ Health care is under extreme pressure with surging cases. If you can avoid even one additional contact, you are helping. This is a temporary and urgent request (from a health care provider).

#MedTwitter #HCWs @IMPACT4HC
Read 10 tweets
Dec 21, 2021
1/ Q: Is it true that #Omicron is less severe than previous variants?

A: We HOPE so, but we don’t know yet. The evidence so far is mixed.

dearpandemic.org/is-omicron-les…
2/ We are WAY past due for some good variant news. But pinning our #Omicron hopes on a less virulent variant is not wise for 2 reasons:

1) It might not be less severe in those who are “immune naïve” (neither vaccinated nor with a previous infection—still millions of people).
3/ 2) Many more infections *even* if less severe can still lead to an avalanche of hospitalizations and deaths, and the risk of long Covid.

@AdamJKucharski raised this last December w/ the rise of Alpha:
Read 25 tweets
Dec 16, 2021
1/ Nerdy Girl @drjenndowd (🇺🇸 in 🇬🇧 ) writing from not-so-sunny England, home of the strangest shaped epidemic curve ever seen.

"Buckle up America."

dearpandemic.org/buckle-up-amer…
2/ And by buckle up, I mean BOOST-UP. And take other sensible precautions, especially leading up to the holidays. Things are not looking so good.
3/ Omicron has a significant foothold here, currently estimated at over 30% of current cases in the UK and doubling every 2-3 days 😳. In London where Omicron is a whopping 60+% of the cases, Omicron cases are adding to, but not displacing Delta…yet .
Read 24 tweets
Apr 16, 2021
1/ Q: Do we know more about whether the vaccines reduce transmission?

A: YES! Evidence continues to mount that the vaccines DO in fact reduce transmission.

#vaccineswork
dearpandemic.org/do-vaccines-re…
2/ ➡️ While the Nerdy Girls are still dreaming of transmission being tested in the clinical trials (call us☎️), the data pouring in from around the world strongly suggests that the vaccines are very good (but not perfect) at reducing ALL infections & by extension transmission.
3/ Recall the clinical trials (largely) tested only participants who developed symptoms. One possibility is that vaccines reduce the severity of COVID-19 to the point of no symptoms, but still allow the virus to replicate in the nose and throat & potentially be spread to others.
Read 20 tweets
Apr 13, 2021
1/ Breaking news: Federal officials hit the pause button on #JohnsonandJohnson vaccine.

Giving themselves runway to perform all appropriate due diligence, the @US_FDA & @CDCgov have called for a temporary pause in the use of the #JandJ vaccine. Image
2/ Their diligence will analyze the cases of 6 U.S. women who developed very rare blood clots after receiving the J&J vaccine. Nearly seven million people have received this vaccine to-date in the U.S.
3/ Clinical notes:

All 6 events happened in women ages 18-48. All happened within three weeks post-vaccination. The pause is specific to the #JohnsonandJohnson vaccine, & not the #Pfizer & #Moderna vaccines.
Read 8 tweets

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