As businesses & restaurants reopen, it’s important to remember that #COVID19 is still here, waiting for opportunities to infect as many people as possible.
We can take some basic measures to limit spread, but it requires an understanding of why that’s still important. Thread⬇️
We still don’t know how many people have been or are currently infected with #COVID19.
More testing is necessary to help us understand basic principles about prevalence and incidence, which informs just about all other public health measures.
Rate of infection is also important. This will change over time & is subject to a LOT of factors (proximity, activities, time in close contact).
Current #COVID19 estimates: 1 infected person can infect 2 others.
Montelukast blocks part of the leukotriene pathway, which can be activated as part of the late phase allergic response for people with environmental allergies (pets, pollen, etc) or asthma.
It is NOT an antihistamine.
It has NEVER been a 1st line treatment for asthma/allergies.
Montelukast can help some people as an add on treatment when their allergic rhinitis or asthma is not well controlled with other medications.
It is commonly misused by itself to treat allergic rhinitis, which is not effective. New FDA warning encourages not using as such.
You see, I farted a lot last week. I was also bloated. I was curious why, so I turned to the internet.
The 1st link informed me that I may have a food intolerance, so I looked that up ⬇️
I quickly found some handy dandy quizzes designed to see if I may have a food intolerance.
Question 1 - excessive flatulence. Check.
Question 2 - wait, what? Why is a food intolerance quiz asking if I have metallic taste in my mouth or blurry vision?
There's more ⬇️
OMG!!! According to this quiz, a food intolerance could be causing my AGGRESSIVE OUTBURSTS😱
And now I may have finally found a reason for my clumsiness!!!
Lastly, this quiz associates food intolerance with arthritis, psoriasis and all sorts of chronic conditions.
10% of people reading this believe they are allergic to penicillin, but >95% of you are not actually allergic.
Inappropriate labeling of penicillin allergy is rampant and leads to unnecessary avoidance, use of less effective alternatives, & antibiotic resistance. Thread⬇️
Too many unqualified people have the ability to label someone as having penicillin allergy, which stays on the medical record forever.
The fact is, true allergy is much more rare than suspected. Side effects are common, as are other symptoms, which get mislabeled as ‘allergy’
Simple questions can stratify risk for penicillin allergy.
No increased risk or reason to avoid based on:
-Family history (drug allergy not inherited)
-Received again without problems
-Diarrhea, upset stomach, yeast infections (side effects) #nationalpenicillinallergyday
Primary outcome - 67% of participants could tolerate a single dose of 600 mg (total 1043 mg) peanut vs 4% in placebo after ~12 months of peanut oral immunotherapy (300 mg daily maintenance)
One peanut kernel contains about 250-300 mg of protein.
AR101 peanut immunotherapy has a goal daily dose of 300 mg.
There is a gradual build up starting with very small doses and then the maintenance dose must be taken daily. nejm.org/doi/suppl/10.1…
Anyone who uses IgE allergy tests should be able to predict results BEFORE testing is done...and communicate that to the patient
IgE tests are NOT 'positive' or 'negative'. Can only determine likelihood of allergy being present, determined by history. A #WednesdayWisdom thread⬇️
The most important concept for patients and medical providers to understand about IgE testing is the HUGE difference between sensitization and allergy.
Example: ~30% of people have detectable IgE to foods, but only 5-8% are actually allergic.
Rely on test alone = overdiagnosis
Skin prick testing introduces small amounts of allergen to the allergy cells in the skin.
If IgE towards allergen is present, the cells will open and release histamine = red, itchy bump.
Size of bump = likelihood of allergy being present.