Singular (generic = montelukast) is a medication commonly used to treat #asthma & allergic rhinitis.
Last week, the FDA announced a ‘boxed warning’ & new discussion points with patients regarding side effects.
I’ll provide some thoughts in this thread fda.gov/news-events/pr…
Last week, the FDA announced a ‘boxed warning’ & new discussion points with patients regarding side effects.
I’ll provide some thoughts in this thread fda.gov/news-events/pr…
Montelukast blocks part of the leukotriene pathway, which can be activated as part of the late phase allergic response for people with environmental allergies (pets, pollen, etc) or asthma.
It is NOT an antihistamine.
It has NEVER been a 1st line treatment for asthma/allergies.
It is NOT an antihistamine.
It has NEVER been a 1st line treatment for asthma/allergies.
Montelukast can help some people as an add on treatment when their allergic rhinitis or asthma is not well controlled with other medications.
It is commonly misused by itself to treat allergic rhinitis, which is not effective. New FDA warning encourages not using as such.
It is commonly misused by itself to treat allergic rhinitis, which is not effective. New FDA warning encourages not using as such.
Physicians (should) have been discussing possible neuropsychiatric side effects of montelukast with patients for the past decade.
The new FDA warning comes after longer term evidence of these previously known rare side effects.
This isn’t ‘new’, but is more proactive.
The new FDA warning comes after longer term evidence of these previously known rare side effects.
This isn’t ‘new’, but is more proactive.
Neuropsychiatric side effects with montelukast can affect children & adults.
-These are rare
-Typically occur in 1st 1-2 months of use
-Watch for sudden change in behavior, nightmares, depression
-Typically reversible once stopped
-If currently using w/o problems, likely ok
-These are rare
-Typically occur in 1st 1-2 months of use
-Watch for sudden change in behavior, nightmares, depression
-Typically reversible once stopped
-If currently using w/o problems, likely ok
Summary:
-Montelukast should be used thoughtfully in patients w poorly controlled asthma or allergic rhinitis as ADD ON to other proven meds
-Don’t use by itself for mild allergies
-All patients should receive info re: possible side effects
Details: fda.gov/news-events/pr…
-Montelukast should be used thoughtfully in patients w poorly controlled asthma or allergic rhinitis as ADD ON to other proven meds
-Don’t use by itself for mild allergies
-All patients should receive info re: possible side effects
Details: fda.gov/news-events/pr…
Hope this thread offers some insight. As always, please discuss all individual concerns with your personal doctor.
This new boxed warning will hopefully help prescribers be more proactive in discussions with patients...and more thoughtful about when to consider montelukast
This new boxed warning will hopefully help prescribers be more proactive in discussions with patients...and more thoughtful about when to consider montelukast
Aaaand I misspelled singulair in my 1st Tweet in this thread 🤦🏻♂️
Can’t edit Tweets, so I’ll live with the mistake...apologies for the error.
Can’t edit Tweets, so I’ll live with the mistake...apologies for the error.
