Ziyad Al-Aly, MD Profile picture
Feb 7 12 tweets 7 min read
The latest from our team on the long-term cardiovascular consequences of Covid-19 in @NatureMedicine

@VAResearch @vahsrd @WUSTLpubhealth @WUSTLmed @WUSTLnews @VREFSTL @NaturePortfolio

@Biostayan @BCBowe

A thread

nature.com/articles/s4159…
In a cohort of more than 153 k people with COVID-19, 5.6 million contemporary controls, and 5.8 million historical controls without evidence of infection

We show increased risks of a wide range of cardiovascular diseases at 1 year
These include cerebrovascular disorders, dysrhythmias, ischemic and non-ischemic heart disease, pericarditis, myocarditis, heart failure and thromboembolic disease.
The risks of cardiovascular diseases were evident in all subgroups: young and old, White and Black people, males and females, and several other subgroups
The risks were evident in people who had no prior history of any cardiovascular disease
The risks were evident even among people who did not need hospitalization or ICU care during the acute phase of SARS-CoV-2 infection
Governments and health systems around the world should be prepared to deal with the likely significant contribution of the COVID-19 pandemic to a rise in the burden of cardiovascular diseases

nature.com/articles/s4159…
Because of the chronic nature of these conditions, they will likely have long-lasting consequences for patients and health systems and also have broad implications on economic productivity and life expectancy

nature.com/articles/s4159…
Addressing the challenges posed by Long COVID will require a much needed, but so far lacking, urgent and coordinated long-term global response strategy

nature.com/articles/s4159…
I am happy that the cancer moonshot is being re-launched. We need a Long Covid Moonshot

#LongCovidmoonshot
Grateful to my team, our funders @VAResearch @vahsrd our Editors and Referees.

nature.com/articles/s4159…
Most grateful to the #LongCovid patient community whose heroic and historical advocacy inspired us and continue to inspire us to work very hard on #LongCovidResearch

#LongCovidisfact

nature.com/articles/s4159…

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More from @zalaly

Sep 1, 2021
The latest from our team:

A deep dive into the long-term consequences of #COVID19 on kidney function and disease

#longcovid #PASC

@VAResearch @vahsrd @WUSTL @WUSTLpubhealth @WUSTLmed @WUSTLnews @VREFSTL
@Biostayan @BCBowe @JASN_News @ASNKidney

jasn.asnjournals.org/content/early/…

🧵
We previously provided a high dimensional characterization of post-acute sequelae of COVID-19

We showed that #LongCovid can affect nearly every organ system.

@Nature @NaturePortfolio

#COVID19 #PASC

nature.com/articles/s4158…
What happens to long term kidney function in people who survive acute #COVID19 ?

And are they at increased risk of #kidney disease?

To address this, we built a cohort of 89,216 US veterans with #COVID19 and 1,637,467 non-infected controls.

jasn.asnjournals.org/content/early/…
Read 9 tweets
Apr 22, 2021
Happy to share the latest paper from our team in @nature

A comprehensive characterization of post acute sequelae of COVID-19

#longcovid #PASC

nature.com/articles/s4158…

@VAResearch @vahsrd @WUSTL @WUSTLpubhealth @WUSTLmed @WUSTLnews @VREFSTL @Biostayan @BCBowe
#Longcovid is a multifaceted disease; it can affect multiple organ systems including respiratory, cardiovascular, nervous, mental health, metabolic, gastrointestinal, kidneys, and other organ systems.
People with #longcovid have increased risk of incident use of several therapeutics including pain medications (opioids and non-opioids), antidepressants, anxiolytics, antihypertensives, and oral antihyperglycemics and evidence of laboratory abnormalities in multiple organ systems
Read 10 tweets

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