Biotech2k Profile picture
Feb 22 5 tweets 1 min read
I have been doing my fully DD in the NGS space after the $PACB back to back disappointing quarters. I needed to know if this was a company specific problem or some softness in the space related to Covid.
First, I went back to $ILMN as they are the top dog in this space. There was no weakness in their numbers or any mention of weakness. That concerned me for $PACB, but $ILMN is a huge commercial business.
Then came the $TXG earnings. They did mention seeing some weakness in the space related to labs running at lower levels. That was the first sign of weakness in the space.
Then $TWST had earnings. Their earnings call seemed to show no issues with NGS, but on the Leerink call, they asked about the weakness in the NGS numbers for last quarter and full year 2022 guidance.
This means that the falling Covid numbers could signify an end is coming for NGS challenges and we could see a much better 2nd half 2022 for these companies.

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More from @Biotech2k1

Feb 23
1/ Sharing some #crypto learning with you all. I am a hardcore biotech investor, but I often dabble in new technologies when I see opportunity. I did this with the Healthy Eating stocks several years ago. I also did a big jump into Internet of Things back about 8 years ago.
2/ So I started learning about this #crypto thing. At first, I hated the idea and did the work to prove how worthless it was. I have to admit, it does have a lot of challenges to work out yet like massive fees everywhere you look. Most of the coins are complete fraud coins.
3/ I took the time to do a ton of research and sign up for a few exchanges. Here is my experience for US based investors. I stuck with the top 2 coins of #BTC and #ETH. I also think I might do some DOT later. The rest of the coins seem like a waste of money.
Read 18 tweets
Feb 21
1/ Bargain Hunting in #iPSC:

These are the companies that rank in my top picks for people to use as a jumping off point to do their own research.
2/ My top pick here would be $FATE. They have been the leader in this space for years. They have strong management and strong science. They are the only company to have early phase 1 data so far.
3/ The data has been very encouraging, but it still needs to fully develop to know where it will fit into the treatment landscape. They have multiple programs across blood cancers and now moving into solid tumors.
Read 15 tweets
Feb 20
1/ Bargain Hunting in #TPD:

These are the companies that rank in my top picks for people to use as a jumping off point to do their own research.
2/ My first pick here will be $ARVN, but not because I like their science the most. I am actually not that thrilled with their ER and AR program. I picked them as they are the most established with data and have a big partner.
3/ They made a big partnership for their ER program. They now have $1.6 billion cash. That is nearly half of their $3.6 billion market cap. That makes them really cheap while we wait for some of the bigger programs like KRAS and Tau.
Read 16 tweets
Feb 19
1/ Bargain Hunting in #Genomics:

These are the companies that rank in my top picks for people to use as a jumping off point to do their own research.
2/ My top pick here is clearly $BEAM. I think they got the best management and science. I know it is still a very expensive company at $4.5 billion market cap and not even any human data yet. It should probably be worth more like $3 billion.
3/ I do think they have the best long term potential with their wholly owned programs and a long list of partnerships.
Read 14 tweets
Feb 18
Ranking my Companies by Management:

By science theme and management.
#AI/#ML in biotech

1. $RLAY
2. $RXRX
3. $SDGR
4. $EXAI (have not heard him present yet)
#TargetedOcology

1. $BPMC
2. $MRTX
3. $ERAS
4. $RVMD
Read 7 tweets
Feb 18
1/ The Battle for the Future of Targeted Oncology:

This is a space I have been focused on for years. The traditional methods of cancer treatment have been very toxic. Its about trying to kill the cancer faster then the patient. There has to be a better way to help patients.
2/ This brings about targeted oncology which is actually a very big space. The focus for me has been in the genetic cell pathways that mutate to drive uncontrolled cell growth. These are often referred to as the kinase or TKI companies.
3/ Its actually much bigger then just targeting kinases as many of these pathways have many kinases, enzymes, proteins and other factors that play key roles in these cell pathways.
Read 11 tweets

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