Thread by @firefoxx66

After 2 long virtual years, *so happy* to be back at #UCSDdynamics Dynamics & Evolution of Human Viruses in person in beautiful San Diego! Brilliant sessions on everything from #HIV to #SARSCoV2 & many viruses in between, with fantastic global scientists & experts!

Opening the conference, @manonragonnet shows the relationship of drug & antibody treatment for #SARSCoV2 on the appearance of resistance mutations, as well as their ability to escape. These mutations are rare in the general pop; mostly assoc with treatment.
#UCSDdynamics

@sarehchimeh gives an interesting talk on how & whether we can detect increased selection on surface-exposed areas of #HumanViruses - since these are exposed to the immune system, might we expect to see them evolving faster?
#UCSDdynamics

Tying up the 1st session beautifully, @SheriHarari speaks on her work on adaptive evo of #SARSCoV2. Viral load rebound can be a red flag for resistance, & key mutations missing between chronically infected & VoC defining are of interest!

#UCSDdynamics

https://twitter.com/SheriHarari/status/1539485613774217217?t=DvCxytE0AUPERCYboHVumQ&s=19

To open the next #UCSDdynamics session, @viralverity gives a great breakdown of the origin of #SARSCoV2 Variant of Concern Alpha, & what this may mean for other & future VoCs. It seems most likely that Alpha came from a chronic infection.

#HumanViruses

Turning to HIV, @twoseventwo gives a very nice overview of looking into age & sex dynamics in HIV transmission, using two approaches to try and better understand who infects whom at what points. Including a lovely chart of the relationships!
#UCSDdynamics #HumanViruses

And closing out a brilliant 1st day, @heather_eGrant takes us through the incredibly interesting historical HIV subtype A1 & D sequences in Uganda. The rise & fall of subtype D is very interesting, & possibly related to cell tropism!
#UCSDdynamics #HumanViruses