Antoine FLAHAULT Profile picture
Sep 1 9 tweets 4 min read
1/9 - “[A new study] suggests that updated boosters [of #COVID19 vaccines] seem to offer much the same protection as an extra dose of the older vaccines — particularly when it comes to keeping people out of hospital.”
nature.com/articles/d4158…
2/9 - “On 15 August, the United Kingdom became the first country to approve these ‘bivalent’ vaccines, which are based on the #Omicron #BA1 lineage and the original #SARSCoV2 sequence identified in Wuhan, China, and will soon roll them out. [And today EMA].”
3/9 - “Largescale efficacy trials […] which involved randomly assigning tens of thousands of people to get a vaccine or placebo and following who got infected are no longer practical, possible or ethical in 2022.”
4/9 - “Updated #COVID19 vaccines have instead been trialled in smaller groups. To gauge effectiveness, developers have typically measured participants’ immune responses, particularly infection-blocking ‘neutralizing’ antibodies, and compared them with […] the original vaccine.”
5/9 - “Most of these trials found that updated vaccines — based not only #Omicron, but also older variants including Beta — performed a bit better in this measure than the original vaccines. “This is a clearly superior booster,” Moderna’s president, Stephen Hoge, told investors.”
6/9 - “Studies suggest that higher levels of neutralizing antibodies equate to better protection against #COVID19. But it wasn’t clear from the updated vaccine trials how much more effective they might be.”
7/9 - “Bivalent vaccines that included the original vaccine looked no more effective than vaccines based solely on a newer variant. […] the main message of the analysis should be that any #COVID19 booster is a good one.”
8/9 -“Other scientists question the decision to pursue variant boosters, when the benefit is so small. Worry that people are being misled into thinking updated vaccines are vastly more effective than existing vaccines, and might then expose themselves to greater infection risks.”
9/9 - “In the long run, it probably makes sense to develop variant-based vaccines, but the idea that they need to closely match circulating viral strains is unrealistic and counterproductive when highly effective vaccines are already available.”

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More from @FLAHAULT

Aug 31
1/7 - “As the world grapples with the reality of living with #COVID19, a rogue's gallery of deadly pathogens seems to have stepped up the attack.”
via @ejustin46
newsweek.com/2022/09/09/how…
2/7 - “#Monkeypox, a close relation of smallpox, is officially a public health emergency worldwide. The current outbreak—the first large one ever outside of Africa—has spread globally to more than 45,000 people, including more than 16,000 confirmed cases in the US.”
3/7 - “And #polio, a disease routinely referred to as "eradicated," is circulating in and around New York City and London, bringing with it the irreversible paralysis that strikes about one of 200 people infected with the disease.”
Read 7 tweets
Aug 31
1/6 - “Un diagnostic précoce, l’isolement des pers. porteuses du virus, le traçage des contacts, des stratégies de comm., de prévention et de vaccination ciblées sur les groupes à risque sont essentiels pour espérer contrôler efficacement le #monkeypox.”
tnova.fr/societe/sante/…
2/6 - “Pour les associations de lutte contre le sida, en 1ère ligne face au #monkeypox, la hiérarchie des risques est sans appel: les pouvoirs publics auraient tort d’amoindrir l’efficacité de la réponse par crainte de nourrir la stigmatisation à l’égard des groupes à risque.”
3/6 - “Il faut rester ouvert vis-à-vis des modes de transmission et retenir les leçons récentes de la pandémie de #COVID19. Il n’est pas impossible qu’une partie des contaminations au sein même des communautés HSH aient eu lieu par voie aérosol dans des bars ou des clubs.”
Read 6 tweets
Aug 30
1/9 - “The potential impact on heart and brain disease poses challenges to healthcare systems globally.”
ft.com/content/26e073…
2/9 - “Covid generated a kind of epidemiological aftershock by leaving people susceptible to a huge range of other conditions, threatening global health systems already struggling with insufficient resources and ageing populations.”
3/9 - “A Financial Times analysis of data from the UK’s NHS, showed significant rises in deaths from heart disease since the start of the pandemic in all but the very oldest age groups. In the 40-64 age group, heart attack deaths increased 15 per cent in 2021 compared with 2019.”
Read 9 tweets
Aug 30
1/9 – Aug 30 to Sep 05 –
"Around the #COVID19 World in 80 Seconds"!
Daily epidemic 7-day forecasting for 300+ countries/ territories on our dashboard:tinyurl.com/COVIDdashb
Data source: coronavirus.jhu.edu & ourworldindata.org/coronavirus
Powered by @ISG_UNIGE & @SDSCdatascience
2/9 – Western Europe
Improvement all over the sub-continent in its #COVID19 epidemic activity, with remaining medium-low mortality.
- (Slow) landing in (AU (R-eff=0.97); FR=0.94; SP=0.95; SE=0.94); CH; LUX; FL; DK; BE; PT; NL; IT; DE;
- Safe in the UK; IRL; NO.
3/9 – East-Central Europe
- Rise in its #COVID19 epidemic activity in Russia (R-eff=1.14); Ukraine=1.13, with low mortality;
- Plateau in Pol=0.97; [Slovn=1.0], low [high] mortality.
(Slow) landing in (Hung=0.94; CZ=0.93); Bulg; Alb; Greece; Rom; Serb; Croat; Latv; Lith.
Read 11 tweets
Aug 30
1/4 – France (R-eff=0.94) is slowly landing towards its #COVID19 safety zone, with low mortality.
14,817 cases and 23 deaths/day to be reported by Sep 05, if at same pace.
Regional forecast for Aug 30 to Sep 02: tinyurl.com/COVIDfrance
By:@ISG_UNIGE & @SDSCdatascience
2/4 – Eleven mainland Régions are either (slowly landing towards) or plateauing above their #COVID19 safety zones,with low [medium] mort:
AURA (R-eff=0.97);
[Bg-Fr-C=0.96];
Bret=0.97;
CvL=1.06;
(G-Est=0.94);
H-de-Fr=0.95;
IDF=1.02;
Norm=1.04;
Nouv-Aq=0.96;
(Occit=0.92);
PdL=0.99.
3/4 – Only two mainland Régions are landing towards their #COVID19 safety zones, with remaining medium levels of mortality:
Corse (R-eff=0.82);
PACA=0.73.
Read 6 tweets
Aug 29
1/9 - "A Chinese think tank issued a rare public disagreement Monday with the ruling Communist Party’s severe #ZeroCovid policy, saying curbs that shut down cities and disrupt trade, travel and industry must change to prevent an “economic stall."
apnews.com/article/covid-…
2/9 - The Anbound Research Center gave no details of possible changes but said President Xi Jinping’s government needs to focus on shoring up sinking growth. It noted the United States, Europe and Japan are recovering economically after easing anti-disease curbs."
3/9 - "Preventing the risk of economic stall should be the priority task,” the think tank said in a report titled, “It’s Time for China to Adjust Its Virus Control and Prevention Policies."
Read 9 tweets

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