This systematic review comes to the conclusion that physical activity with regular aerobic training of moderate to vigorous intensity appears to help preserve leukocyte telomere length, a biomarker of biological aging associated with several age-related diseases. Image
* Key points:
- As life-expectancy increases, lifestyle choices like exercise take on increasing importance in healthy aging.
Telomere attrition is a molecular marker of aging. Thus, physical activity may influence the aging process through telomere biology, namely leukocyte telomere length and telomerase activity.
- The amount of reduction in sedentary behavior appears to have a positive effect of preserving and increasing leukocyte telomere length.
- With respect to history of previous exercise, current level of physical fitness appears to have a more important beneficial role than previous exercise on leukocyte telomere length.
In fact, amongst athletes, a history of physical activity during youth does not appear to play a protective role in preserving or increasing leukocyte telomere length.
Nevertheless, there is strong evidence that, lifelong elite- or master-athletes will have increased leukocyte telomere length in comparison with inactive controls.
* Caveats:
- While the majority of studies highlight positive effects of physical activity on telomere dynamics, there lacks a consensus on the most beneficial exercise type and training modality (intensity, duration and frequency).
- Although the majority of the studies underscore the beneficial role of physical activity on telomere dynamics and aging, the molecular events in leukocyte telomere length preservation and/or elongation remain poorly understood.
Telomere dynamics are tissue- and cell-specific and are also dependent upon proliferative activity; as such, grasping the molecular mechanisms induced by exercise remains a challenge.
Along with further understanding of telomere biology and potential deleterious events at the molecular level (e.g. oxidative stress), tissue- and cell-type differences in their analyses of leukocyte telomere length and telomerase need to also be considered.
- Future studies should provide more detailed information on the physical fitness level of the participants, as well as characteristics of the exercise training modality, for standardization and comparison, in order to draw more definitive conclusions.
Physical Activity on Telomere Length as a Biomarker for Aging: A Systematic Review (open access)…

#exercise #Workout #TrainHard #GymLife #GymTime #muscle #strength #lift #GetStrong #cardio #hiit #aging #longevity

• • •

Missing some Tweet in this thread? You can try to force a refresh

Keep Current with Nick Krontiris

Nick Krontiris Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!


Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @nick_krontiris

Sep 10
This one found average and slow walking pace to be associated with a higher risk of incident type 2 diabetes, independent of major confounding factors with these associations even being consistent across different physical activity levels and walking time. ImageImageImageImage
- Compared with brisk walking, average and slow walking paces were associated with a higher incidence of type 2 diabetes in both men and women, independent of sociodemographic factors, diet, adiposity, and physical activity level.
- Among people with average and slow walking paces, high levels of physical activity did not attenuate the excess type 2 diabetes risk attributable to slow walking pace.
Read 5 tweets
Sep 10
Using data from 3095 people living in Sweden, this one identified the most relevant predictors of 18-year mortality in individuals aged ≥60 years. ImageImage
- Individuals’ social connections and civil status were identified as meaningful predictors of mortality, as well as socio-environmental characteristics such as living conditions, civil status, and leisure activities.
- Physical function also had a strong prognostic role, as the functional status domain, encompassing several measures of physical performance and dependency, was the only single domain that showed comparable predictive performance to chronological age.
Read 12 tweets
Sep 10
Here, objectively-measured moderate and vigorous physical activity were found to be associated with lower risk of affective disorders, including depression and anxiety. ImageImageImage
- A higher level of physical activity was associated with lower risk of affective disorders up to 500 min of moderate and 120 min of vigorous physical activity per week.
- At an equivalent amount of time, vigorous physical activity was associated with lower risk of affective disorders than moderate physical activity.
Read 9 tweets
Sep 10
Here, any intensity of physical activity was associated with a decrease in total cholesterol, with higher MVPA being associated with reduced SBP, whereas higher LIPA being associated with decreased measures of adiposity, in individuals with coronary heart disease. Image
- 72 participants (predominantly males) with a mean age of 64 years were recruited to this 12-month observational study.
- Participants were included if they had stable CHD and were receiving optimal medical treatment ± revascularisation.
Read 10 tweets
Sep 10
This systematic review and meta-analysis suggests that exercise combined with a high protein intake is more likely to preserve fat-free mass than exercise alone during weight loss in adults with overweight or obesity, regardless of the weight loss approach used. ImageImage
- The study's aim was to investigate the effect of exercise training, protein, calcium, and vitamin D supplementation on the preservation of fat-free mass during non-surgical and surgical weight loss and of the combination of all interventions together in adults with obesity.
- Exercise Training + High Protein intervention was superior in every comparison and independent of the outcome and type of induced weight loss.
Read 12 tweets
Sep 10
This one found cardiorespiratory fitness to be associated with small, but beneficial changes in cerebrovascular hemodynamics in adults without CVD risk factors, but with men and women showing some differences in those benefits. Image
- Greater VO2peak was associated with small but beneficial changes in cerebrovascular hemodynamics in adults without CVD risk factors.
These included greater MCA conductance and pulsatile damping, and lower large artery stiffness, forward wave energy, and mean arterial pressure in the combined sample of males and females, with sex-specific associations in large artery stiffness and carotid pulse pressure.
Read 17 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!


0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy


3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!