Do doses of fat respond the same way as glucose?
A 🧵 1/8
#metabolism #fat #nutrition #diet
A 🧵 1/8
#metabolism #fat #nutrition #diet
https://twitter.com/Gonzalez_JT/status/1576495111139053569
This time, the measure of interest is the level of fat in the blood (triacylglycerol; aka TAG)
When fasted, levels of TAG are low (left)
High levels of TAG make the plasma part of blood look cloudy/turgid (right)
2/8
When fasted, levels of TAG are low (left)
High levels of TAG make the plasma part of blood look cloudy/turgid (right)
2/8
In contrast to glucose, the more fat eaten in a meal, the higher the level of TAG
Does the type of fat matter?
3/8
Does the type of fat matter?
3/8
Not really, most fats show a similar response.
What about if we increase intake of all macronutrients?
4/8
What about if we increase intake of all macronutrients?
4/8
In this study by @AaronHengist people ate pizza 🍕 until comfortably full, or ate as much as they could tolerate
pubmed.ncbi.nlm.nih.gov/32248846/
5/8
pubmed.ncbi.nlm.nih.gov/32248846/
5/8
TAG levels were slightly higher when eating maximally, but less that would be expected given the doubling of fat intake.
Why so?
6/8
Why so?
6/8
The additional carbs and protein stimulated insulin secretion (fat has little effect on insulin secretion).
Why is this relevant?
7/8
Why is this relevant?
7/8
Insulin plays a key role in fat metabolism by:
1) suppressing fatty acid availability to the liver (precursors for TAG released by the liver as VLDL)
2) directly suppressing VLDL secretion
3) stimulating clearance of TAG by adipose tissue (by stimulating LPL)
End 8/8
1) suppressing fatty acid availability to the liver (precursors for TAG released by the liver as VLDL)
2) directly suppressing VLDL secretion
3) stimulating clearance of TAG by adipose tissue (by stimulating LPL)
End 8/8
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