Discover and read the best of Twitter Threads about #glucose

Most recents (24)

@ir_rkp #Korsakov @MikaLintila
#Gasgrid. #LNG alus ei tuota #kaasua, vaan varastoi #Venäjä'n, aiemmin #Baltiasta ostettua, n. 3x hintaan.
@valtionomistus
- 10v. ajalta terminaalin kokonaiskustannuksiksi arvioidaan noin €460 miljoona, eli noin €126 000 päivässä
@ir_rkp @MikaLintila @valtionomistus #GreatReset=#SuurTyöttömyys-#Hätätila
#WEF-#Marxist -ideologia lahtaa yritykset #kaasu'lla. @valtionomistus
#Gasgrid Imatra #Räikkölä vs. #Korsakov
- Korsakov on satamakaupunki ja piirikunta #Sahalini'n saaren eteläpäässä Venäjän  Sahalinin alueella. 
@ir_rkp @MikaLintila @valtionomistus #Uniper-#Gasgrid #skandaali.
#YGLs veijarit keksivät roudata kaasun #Räikkölä'n sijasta näin. @TyttiTup
#Prigorodnoje'n satama 10km #Korsakovi'n itäpuolella on #LNG'n vientiin erikoistunut satama
From: Port of #Korsakov
To: Port of #Gibraltar (->#Inkoo)
Read 19 tweets
@SRLucie92 @elonmusk @EU_Commission @kokoomus @vihreat @sfprkp @persut #AliBaba & #WorldBank & #IMF and 40 world wealthiest #thieves.
- Who collects all the world's #CarbonTaxes in their own #coffers?
- The World Bank - IMF is owned and controlled by NM #Rothschild and 30 to 40 of the wealthiest people in the world.
Read 10 tweets
Central to Alzheimer's pathology is a phenomenon known as brain hypometabolism. Let me explain better what that term means. 🧵 (1/25) #alzheimers #AD #neurotwitter
Brain hypometabolism refers to a state of reduced metabolic activity in the brain, characterized by a decreased uptake and utilization of glucose - the primary #energy source for brain cells. (2/25)
This disastrous metabolic slowdown is not just a mere lack of energy, although that would be devastating enough. It triggers a cascade of effects that impair neuronal function and disrupts communication between #brain cells. (3/25)
Read 25 tweets
Should people be concerned with blood glucose concentrations if they don’t have prediabetes or diabetes?
1/10

#glucose #health #biohack #science #metabolism #cgms #hba1c #sugarspikes
For context, the relationship between LDL-cholesterol concentration and coronary heart disease risk appears linear across the entire physiological range

What about glucose?
2/10
For glucose, it might depend how it’s measured:

STANDARDISED TESTS (reflect underlying physiology)
-Fasting [glucose]
-2-h [glucose] post-OGTT

FREE-LIVING MEASURES (reflect underlying physiology x acute behaviour)
-HbA1c
-CGMS variables

What do the data show?
3/10
Read 10 tweets
Research suggests that these changes in cognitive function (#brain fog, poor memory, mood, and focus) may be accompanied by dysfunction in #brain energy metabolism that can be treated with #metabolic therapies. (1/17)
Cognitive dysfunction can arise when the brain's energy supply is disrupted. It's called brain hypometabolism. (2/17)
Head traumas and concussions in sports or accidents are associated with such changes and can cause behavioral changes and memory loss in adults. But you don't need a history of head injury for cognitive decline to occur. (3/17)
Read 17 tweets
Migraine, a common neurological disorder, may be a metabolic as much as a neurological disease, with the migraine attack serving as a warning signal to increased oxidative stress and/or hypometabolism. (1/21) #neurotwitter #hypometabolism
Despite being primarily studied in terms of neuro-vasculature and neurotransmission, recent research suggests that migraine's pathogenic mechanisms may be linked to metabolism and mitochondrial dysfunction. (2/21) #mitochondria
Magnetic resonance spectroscopy studies have consistently shown decreased ATP levels and abnormal mitochondrial function in migraineurs, suggesting a metabolic component to the disorder. (3/21)
Read 21 tweets
We are discovering exciting things about how therapeutic nutritional ketosis could benefit those living with serious mental illnesses. It's time for a short thread about two main ways this could be happening. 🧵 (1/13)
First is the direct effect of ketones. Scientific studies have shown that people with serious mental illnesses often have trouble using glucose efficiently for fuel. Ketones supply fuel that doesn't depend on insulin or the cell's ability to metabolize glucose. (2/13)
By providing the brain with this alternative fuel source, ketones can help enhance energy production and improve cognitive function in people with serious mental illnesses. (3/13) #lifechanging
Read 13 tweets
3VOLUTION of Homo sapien to HOM3OSTASIEN​

by Dmitry Kats, PhD, MPH
scholar.google.com/citations?user…

- - -

A HOM3OSTASIEN represents the evolutionary step forward undertaken by the homo sapien species (among other mammals) to substantially extend and reestablish healthy, fulfilling,… twitter.com/i/web/status/1…
... "inhibition of nuclear de novo NAD+ synthesis reduced the total levels of NAD+ in the cell and mitochondrial energy metabolism, leading to premature cellular senescence"

"nuclear de novo NAD+ synthesis pathway, controlled by H2AX [i.e., GPR109A aka HOM3OSTASIS.com/2022/11/homo-s…twitter.com/i/web/status/1… ImageImageImageImage
... Little do people know, as they don’t care to review the actual literature, that per se, akin to every other cell in the body, as proved in these high-profile journal-published papers (collecting Internet-dust) by the world's most elite investigators (scientists and/or… twitter.com/i/web/status/1… Image
Read 52 tweets
Let's explore the outcomes of a study that explored the neurobiological evidence in support of improvement in depression with a ketogenic diet and find out what underlying biological mechanisms they uncovered through in vitro and in vivo studies.🧵(1/29) #depression #ketogenic
Basically, they did a literature review from August 2021 to January 2022. Here's what they found. (2/29) #research
People with #depression may have changes in #glucose #metabolism in the brain. The #ketogenic diet boosts cellular #energy metabolism by raising #ketone bodies and replacing glucose as the main fuel source. (3/29)
Read 29 tweets
Taking frequent walking breaks during prolonged sitting could help lower blood sugar and BP

1. Sedentary lifestyle with prolonged sitting hours (>8 hours daily) is common these days.
Frequent walking breaks (1 min or 5 min every 30-60 minutes) could help lower blood sugar and BP
2. When participants took a 5-minute light #walk after every half hour of sitting, the blood #glucose spike after eating was reduced by 58% compared with sitting all day (reduction one would see in a diabetic using insulin or #diabetes medications to control their blood sugar).
3. The largest reductions in systolic blood pressure were observed when the walking break was 1 minute every 60 minutes (-5.2 mm Hg).
Read 7 tweets
The less we eat, the longer we live

1. This seems to be true.
A recent extensive review of studies done in geographies with maximum 100+ aged people showed that most of them practiced some form of calories restriction (CR) right from childhood.
#fasting #Longevity #MedTwitter
2. Calorie restriction (CR) is defined as consuming fewer (10-30% lower) calories as compared to usual.
This can be achieved by either intermittent fasting, or time-restricted feeding or substantially reducing carbohydrate intake.
#nutrition #HealthyEating
3. In ageing, #Insulin increases and insulin sensitivity decreases, which increase the risk of #diabetes, #obesity and #cardiovascular diseases. CR reverses these- reduces insulin levels and increases insulin sensitivity. #Glucose levels also reduce with CR.
Read 10 tweets
Today, almost half of the 4 million Americans living with type 1 diabetes use devices called continuous glucose monitors, or CGMs, to monitor their #glucose levels and regulate their insulin levels in real-time.
@statnews' @KatieMPalmer reviews CGM's here:
reports.statnews.com/products/conti…
@statnews unpacks the differences between the different ways the FDA approves drugs, like accelerated approvals, fast-track designations, and emergency use authorizations. It touches on how we got here, where the agency is headed next, and what's at stake
reports.statnews.com/products/speed…
The potential of the psychedelics industry has never been bigger. Long-stigmatized drugs like esketemine, MDMA and psilocybin are advancing rapidly through clinical trials for treatments of a range of mental health conditions @OliviaGoldhill @statnews
reports.statnews.com/products/the-s…
Read 5 tweets
Q: Which of these would produce biggest the blood sugar response?
(i.e., biggest change in glucose concentration)

Answers below (1/8) 🧵 #glucose #health #metabolism
Have a guess here before reading on to find out if you are right... (2/8)
A: There is no meaningful difference (at least in healthy people) - data from: pubmed.ncbi.nlm.nih.gov/28684634/

How can 75 g glucose (3 times more) not increase glucose more than 25 g?

(3/8)
Read 8 tweets
Fructose Coingestion Does Not Accelerate Postexercise Muscle Glycogen Repletion

Our 2016 paper:
pubmed.ncbi.nlm.nih.gov/26606271/

A thread with figures.

#fructose #glucose #glycogen Image
The gut absorption of the carbohydrate glucose is the limiting factor in using glucose drinks for energy during exercise (carbohydrate oxidation). Fructose is a carbohydrate that is absorbed differently in the gut than glucose. Sucrose consists out of glucose and fructose.

2/ Image
Therefore, a combined ingestion of glucose and fructose allows a higher total carbohydrate absorption rate, oxidation rate, and exercise performance. But does this combination also improve the recovery of the muscle carbohydrate stores (i.e. muscle glycogen) after exercise?

3/
Read 9 tweets
1) Welcome to our new #accredited #tweetorial on the Pathophysiology of #DKD in #T2D: Traditional Teaching and New Insights. Our expert author is Hans-Joachim Anders, MD, @hjanders_hans from @LMU_Uniklinikum of @LMU_Muenchen
2) This #accredited #tweetorial series on the foundations of #kidneydisease #DKD through the lens of #T2D is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance and is intended for healthcare providers.
3) This activity is accredited for #physicians #physicianassociates #nurses #NPs #pharmacists. Past programs still eligible for credit can be found at ckd-ce.com. Faculty disclosures & accreditation statement are at ckd-ce.com/disclosures/. FOLLOW US!
Read 48 tweets
Thanks for the guesses.

A: Exercise!

Group 1: Trained
Group 2: Untrained

Thread 🧵 1/9

#exercise #glucose #metabolism
Here is the original figure

Note the remarkable increase in glucose immediately after intense exercise (110% VO2 max)

So whats going on here?
2/9
Luckily the authors applied tracer methods to understand rates of appearance (Ra) and disappearance (Rd) of glucose

Whilst exercise did increase Rd (lower panel) Ra increased much more ( and even more so in trained athletes)
3/9
Read 9 tweets
I often hear people say venous blood samples are preferable to capillary (fingertip/earlobe) samples.

Why then, do the glycaemic index guidelines make the following recommendation?

pubmed.ncbi.nlm.nih.gov/19079901/

Let’s look a little deeper into this… 🧵 1/9 #glucose #metabolism
We will focus here on glucose concentrations.

With glucose tolerance tests or other postprandial tests, a common aim is to understand the ability of the person to maintain relatively stable glucose concentrations.

I.e. the outcome of the integrated response from all organs
2/9
We could sample blood from a few different sites, e.g.

1) artery
2) superficial vein (normally antecubital fossa of the forearm)
3) capillary (e.g. fingertip)
4) interstitial fluid (e.g. CGMs)

Some options can be seen in the figure
3/9
Read 9 tweets
1) Welcome to an #accredited #tweetorial on optimizing the use of #SGLT2i in the management of #T2D. This program is accredited for 0.50 🆓credits for #physicians #nurses #physicianassociates #nursepratcitioners #pharmacists by @academiccme! I am @tmodarressi of @HeartDoctorNJ.
2) This program is intended for healthcare professionals and is supported by an educational grant from Boehringer Ingelheim Pharmaceuticals Inc. and Eli Lilly Company. See archived programs, all by expert authors, still available for credit at cardiometabolic-ce.com.
Read 47 tweets
1) Welcome to our new #accredited #tweetorial on the Pathophysiology of #DKD in #T2D: Traditional Teaching and New Insights. Our expert author is Hans-Joachim Anders, MD, @hjanders_hans from @LMU_Uniklinikum of @LMU_Muenchen
2) This #accredited #tweetorial series on the foundations of #kidneydisease #DKD through the lens of #T2D is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance and is intended for healthcare providers.
3) This activity is accredited for #physicians #physicianassociates #nurses #NPs #pharmacists 🇺🇸🇪🇺🇬🇧🇨🇦. Past programs still eligible for credit are at ckd-ce.com. Faculty disclosures are at ckd-ce.com/disclosures/. FOLLOW US for regular programs by expert faculty!
Read 48 tweets
#2 B-COMPLEX/MULTI VITAMIN. Buy a liposomal or other form that increases bio-availability. Take 1 capsule w/Breakfast and Lunch. If you have stomach upset, try sublingual (under tongue) EZ Melt B-Complex in AM & Multi w/iron for Dinner. amazon.com/Liposomal-Meth…
#3 OMEGA 3s. Fish Oil, Krill Oil, Algae Oil are all good sources of Omega 3. Be careful the EPA/DHA ratio. EPA helps with inflammation/DHA helps with cognition. You need both! Opt for a 1:1 or 2:1 ratio of DHA to EPA (2:1 ratio eg. 800 DHA/400EPA) amazon.com/3Care-Concentr…
Read 93 tweets
Niveles elevados de glucosa en sangre (hiperglucemia) en pacientes con #COVID19

Abro 🧵👇🏼

1/15

#SARSCoV2 #Diabetes #Glucose
Primero algunos (4) conceptos:

1️⃣ Insulina

Es una pequeña proteína producida por el páncreas. Le indica a nuestras células que deben absorber la glucosa que les llega a través del torrente sanguíneo

2/15

#Insulin #pancreas #metabolism
2️⃣Adiponectina

La adiponectina es una hormona producida por las células que almacenan la grasa (adipocitos), tiene dos funciones principales: hacer que las células sean más sensibles ante la insulina, y...

3/15

#FatTissue #Endocrinology #Hormones
Read 16 tweets
recap of a lil #hydration #sciencefromhome #experiment me & some mates ran over the last ~year. analysis not finished, but will release #bloodsugar data before H4H conf starts🤓

Pt 1. A fair while back we had a rather exciting delivery...What have we been up to?1/ Image
Pt 2. After the rather exciting delivery (and some more) arrived, the study design needed to be finalised:

Non-randomised controlled study where we *planned* for experimenters to do the CONTROL arm first, followed by the INTERVENTION arm

🤔
2/
#hydration #sciencefromhome Image
Pt 3. Equipment ordered & study designed.

Minor problem: i hadnt cannulated in > 1 y & my mates had never learnt at all

Cue odd evening remembering/teaching cannulation on poor Snuffles belly...

*GULP*
My ❤️of #science > my fear of needles it seems
3/
#sciencefromhome #hydrate Image
Read 9 tweets
Tonight we have a special installment of #MitoMonday as @ClaireBensard hosts a #Tweetorial on her recent paper in @CellMetabolism #LateNightWithTheRutterLab
Can a specific metabolic program provoke a cell to become a cancer cell? Focusing mainly on glucose, with some thoughts on fatty acids, and glutamine, we tested the uncoupling of glycolysis and glucose oxidation to induce the transformation from stem cell to cancer cell. 2/
Long ago, Otto Warburg observed that cancer cells perform aerobic glycolysis, but we didn’t know how a cell could control flux from cytosolic glycolysis to mitochondrial glucose oxidation until the transporter was identified…bit.ly/2RDELqe #MPC 3/
Read 23 tweets

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