⚠️Disclaimer:
Due to the complexity of this structure, this tweetorial will be composed of three main parts.
1️⃣ Gross anatomy and microscopic anatomy (sort of)
2️⃣ Areas and connections
3️⃣ Clinical Syndromes and curiosities
Hope you enjoy!
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⚠️Before we begin, a great quote about this amazing part of the human brain. 👇⬇️
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What is the frontal lobe?🤔🤨
- Biggest cerebral lobe 🧠
- It occupies 1/3 of all the content inside the skull 💀
- It has multiple complex connections between structures 🥅
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Limits ⛔
- Superior: Central Sulcus, Frontal Pole, Sylvian Fissure 🆙
- Lateral: Frontal Pole, Sylvian Fissure 💠
- Medial: Medial Portion of the Central Sulcus, Frontal Pole, Cingulate sulcus🛣️
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Fissures give rise to different Gyri in the frontal 🧠. As 🥼🩺is much more easier and practical to learn functional areas, but as #AnatomyLovers it is important to know most of these concepts.
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What about the cortex?🧠
- Neocortex in the brain has six layers 🧅
- The diffrerence between the thickness of these six layers is what makes a difference in function
A few examples:👇
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Now that I mentioned function and functional areas. 🤓
We all know Brodmann, right?🤔
His model is based on the cytoarchitectonic structure of the cerebral cortex. 🔬
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More recent studies using fMRI have discovered that areas are not the same for everyone and what it used to be a well divided map is now changing. 🤯🤯
As every human is different, it makes sense that functional areas are not exactly the same for everyone. 🤔
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Below is a more "updated" map of the Functional Areas of the Frontal Lobe👇⬇️🔽
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🤓Enough of Gross anatomy, but before we leave...🤪🤓
Do you know what is Exner's area function❓
a) Spinal-Onset ALS
b) Progressive Muscular Atrophy
c) Progressive Bulbar Palsy/Bulbar-onset ALS
d) Facial onset sensory and motor neuronopathy (FOSMN)
e) Flail-arm syndrome (Vulpian-Bernhardt syndrome): LMN upper limbs and UMN (usually only brisk reflexes in lower limbs)
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f) Hirayama disease: monomelic amyotrophy
g) O’Sullivan-McLeod syndrome: slowly progressive distal amyotrophy of the hands and forearms extending over long periods of time
h) Flail-leg syndrome
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"A characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention." 🩸🧠
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Introduction
What is the use of biomarkers? 🧠
Diagnostic tool🪓
Tool for staging the disease 🥼
Indicator of prognosis📡
Predic or monitor of clinical response to an intervention🚨
Remember: "tools"should aid clinicians, not be the source of all truth.