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#COptiGate, 2022 Xmas Edition.
Following the news about UK-#Moderna partnership, this THREAD is about a key technology used IN ALL mRNA "vaccines" (and IN ALL gene therapy technologies), which is carrying SEVERE HEALTH RISKS that our health regulators decided to ignore.
#COptiGate, 2022 Xmas Edition.
Following the news about UK-#Moderna partnership, this THREAD is about a key technology used IN ALL mRNA "vaccines" (and IN ALL gene therapy technologies), which is carrying SEVERE HEALTH RISKS that our health regulators decided to ignore.
2/
The UK-#Moderna partnership is so that the #NHS will "have access to a UK-made supply of COVID-19 jabs as well as cutting-edge vaccines developed for other respiratory diseases, such as flu and respiratory syncytial virus (RSV)".
Sounds great, no?
NO!
gov.uk/government/new…
The UK-#Moderna partnership is so that the #NHS will "have access to a UK-made supply of COVID-19 jabs as well as cutting-edge vaccines developed for other respiratory diseases, such as flu and respiratory syncytial virus (RSV)".
Sounds great, no?
NO!
gov.uk/government/new…
3/
Last year, starting Aug 2021, I've published a series of threads I entitled #COptiGate. Until that point of time it was unknown to the most of the public that all the COVID19 shots were using a technology that had a negative impact on their safety.
Let's start with a recap.
Last year, starting Aug 2021, I've published a series of threads I entitled #COptiGate. Until that point of time it was unknown to the most of the public that all the COVID19 shots were using a technology that had a negative impact on their safety.
Let's start with a recap.
4/
Codon Optimization is a method to use an alternative genetic sequence to produce the same protein (in the case of COVID19, the spike protein).
There were known risks related to the technology, which health authorities knew of for many years, but…
#COptigate
Codon Optimization is a method to use an alternative genetic sequence to produce the same protein (in the case of COVID19, the spike protein).
There were known risks related to the technology, which health authorities knew of for many years, but…
#COptigate
5/
Health regulators from around the world (e.g., FDA, EMA), which were aware of the multiple risks associated with the codon optimization technology, decided to simply ignore them when it came to the COVID19 shots.
The betrayal of the public was covered in #COptigate threads.
Health regulators from around the world (e.g., FDA, EMA), which were aware of the multiple risks associated with the codon optimization technology, decided to simply ignore them when it came to the COVID19 shots.
The betrayal of the public was covered in #COptigate threads.
6/
The body has defence mechanisms against viral replication in its cells. To bypass it and increase the number of spike proteins produced inside the cells, two major changes were done: the introduction of N1-methylpseudouridine, and Codon Optimization.
#COptiGate
The body has defence mechanisms against viral replication in its cells. To bypass it and increase the number of spike proteins produced inside the cells, two major changes were done: the introduction of N1-methylpseudouridine, and Codon Optimization.
#COptiGate
7/
First, N1-methylpseudouridine:
If you wish to understand why manufacturers such as #Pfizer & #Moderna use it, as well why replacing specific genetic letters with it is a bad idea to our health, I invite you to read my article, linked below:
#PrizerLeak
ehden.substack.com/p/deadly-subst…
First, N1-methylpseudouridine:
If you wish to understand why manufacturers such as #Pfizer & #Moderna use it, as well why replacing specific genetic letters with it is a bad idea to our health, I invite you to read my article, linked below:
#PrizerLeak
ehden.substack.com/p/deadly-subst…
8/
For now, let's focus on Codon Optimization:
1) a "codon" is 3 adjacent genetic letters (or nucleotides). It either encodes information to produce a specific amino acid or serves as a stop signal to terminate translation.
#COptiGate
For now, let's focus on Codon Optimization:
1) a "codon" is 3 adjacent genetic letters (or nucleotides). It either encodes information to produce a specific amino acid or serves as a stop signal to terminate translation.
#COptiGate
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2) Codon Optimization is a technology in which genetic letters (nucleotides) are being substituted by other letters, thus creating a new codon, while not impacting the proteins that ribosomes produces. This technology creates inconsequential (“silent”) mutations.
#COptiGate
2) Codon Optimization is a technology in which genetic letters (nucleotides) are being substituted by other letters, thus creating a new codon, while not impacting the proteins that ribosomes produces. This technology creates inconsequential (“silent”) mutations.
#COptiGate
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3) Inconsequential (“silent”) mutations are known as synonymous mutation.
4) Synonymous mutations contribute to cellular processes which are determining protein structure and function.
5) Synonymous mutations influence protein folding.
#COptiGate
3) Inconsequential (“silent”) mutations are known as synonymous mutation.
4) Synonymous mutations contribute to cellular processes which are determining protein structure and function.
5) Synonymous mutations influence protein folding.
#COptiGate
11/
6) Protein misfolding been linked to Alzheimer, Parkinson disease, and many other pathologies.
7) PROTEIN MISFOLDING resulting in intracellular PAO accumulation IS SUFFICIENT TO CAUSE CARDIOMYOCYTE DEATH & HEART FAILURE.
#COptiGate
ncbi.nlm.nih.gov/pmc/articles/P…
6) Protein misfolding been linked to Alzheimer, Parkinson disease, and many other pathologies.
7) PROTEIN MISFOLDING resulting in intracellular PAO accumulation IS SUFFICIENT TO CAUSE CARDIOMYOCYTE DEATH & HEART FAILURE.
#COptiGate
ncbi.nlm.nih.gov/pmc/articles/P…
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8) For example, these misfolded proteins, known as PRIONS, cause several rare brain disorders, such as kuru, bovine spongiform encephalopathy (“mad cow” disease), and Creutzfeldt-Jakob disease.
Notice, this article is from 2010!
#COptiGate
brainfacts.org/archives/2010/…
8) For example, these misfolded proteins, known as PRIONS, cause several rare brain disorders, such as kuru, bovine spongiform encephalopathy (“mad cow” disease), and Creutzfeldt-Jakob disease.
Notice, this article is from 2010!
#COptiGate
brainfacts.org/archives/2010/…
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9) ALL COVID19 "vaccines" uses large-scale alteration of the gene sequence of the spike protein via codon optimization. They carry potential risk: the modified nucleotide sequences may have unpredictable effects on the structure and function of proteins.
#COptiGate
9) ALL COVID19 "vaccines" uses large-scale alteration of the gene sequence of the spike protein via codon optimization. They carry potential risk: the modified nucleotide sequences may have unpredictable effects on the structure and function of proteins.
#COptiGate
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10) This is a real problem. Here is Katerina Alexaki, from the FDA, explaining how a SINGLE synonymous mutation (mutation that doesn't impact the protein but its 3D object & folding) can result in a disease. In the mRNA "Vaccines" all is synonymous!
10) This is a real problem. Here is Katerina Alexaki, from the FDA, explaining how a SINGLE synonymous mutation (mutation that doesn't impact the protein but its 3D object & folding) can result in a disease. In the mRNA "Vaccines" all is synonymous!
https://twitter.com/eh_den/status/1426885765653573634
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If you want to understand the risks that were created as a result of it, as well as the decision of health authorities to ignore it, I invite you to read this #COptiGate summary thread.
At the end there are links to the original threads on the topic.
If you want to understand the risks that were created as a result of it, as well as the decision of health authorities to ignore it, I invite you to read this #COptiGate summary thread.
At the end there are links to the original threads on the topic.
https://twitter.com/eh_den/status/1433428404712337419
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Here is the first thread I've written on the topic, which I entitled "COPTIGATE - THE WORST DESIGN FLAW IN HUMAN HISTORY THAT IS IMPACTING YOUR HEALTH."
I've published it on Aug 15, 2021. A lot has happened ever since, so let's start!
#COptiGate
Here is the first thread I've written on the topic, which I entitled "COPTIGATE - THE WORST DESIGN FLAW IN HUMAN HISTORY THAT IS IMPACTING YOUR HEALTH."
I've published it on Aug 15, 2021. A lot has happened ever since, so let's start!
#COptiGate
https://twitter.com/eh_den/status/1426885632140394499
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OK, I hope I got everyone on board now, so we can progress to what was discovered ever since I've published my #COptiGate articles (threads).
First of all, huge thanks to @Kevin_McKernan for his work on the topic.
OK, I hope I got everyone on board now, so we can progress to what was discovered ever since I've published my #COptiGate articles (threads).
First of all, huge thanks to @Kevin_McKernan for his work on the topic.
18/
Let's start with "Differences in Vaccine and SARS-CoV-2 Replication Derived mRNA: Implications for Cell Biology and Future Disease" of @Kevin_McKernan & @P_McCulloughMD & Anthony Kyriakopoulos
#COptiGate
Let's start with "Differences in Vaccine and SARS-CoV-2 Replication Derived mRNA: Implications for Cell Biology and Future Disease" of @Kevin_McKernan & @P_McCulloughMD & Anthony Kyriakopoulos
#COptiGate
19/
Here the authors have used the known genetic code that #Pfizer & #Moderna has used, and they analysed it to see if there were any alterations in the secondary structures of mRNAs in SARS-CoV-2 vaccines due to the use of codon optimization.
#COptiGate
Here the authors have used the known genetic code that #Pfizer & #Moderna has used, and they analysed it to see if there were any alterations in the secondary structures of mRNAs in SARS-CoV-2 vaccines due to the use of codon optimization.
#COptiGate
20/
What are secondary structures? Well, a protein is a 3D object, and its interaction with the body is based on it. Since the spike protein which the mRNA was supposed to create has been codon optimized, it meant that it looked differently if you could see it with your eyes.
What are secondary structures? Well, a protein is a 3D object, and its interaction with the body is based on it. Since the spike protein which the mRNA was supposed to create has been codon optimized, it meant that it looked differently if you could see it with your eyes.
21/
Ribosome, the cell unit which is supposed to process the genetic code, is impacted by the changes in the structure. It impacts the transcription, the translation and the replication of the genetic code.
#COptiGate
Ribosome, the cell unit which is supposed to process the genetic code, is impacted by the changes in the structure. It impacts the transcription, the translation and the replication of the genetic code.
#COptiGate
22/
On top of of that, there are the problems that were created as a results of using N1-methylpseudouridine (from now on: m1Ψ). It increase base stacking, RNA stability and melting temperatures compared to uracil, the original genetic letter that it substituted.
#COptiGate
On top of of that, there are the problems that were created as a results of using N1-methylpseudouridine (from now on: m1Ψ). It increase base stacking, RNA stability and melting temperatures compared to uracil, the original genetic letter that it substituted.
#COptiGate
23/
What causes the change in the way ribosomes process genetic data is the emerges of G-quadruplexes. What are they? Because codon optimization increases the GC content of synthetic mRNAs, there can be an enrichment of G-quartets which potentially form G-quadruplex structures.
What causes the change in the way ribosomes process genetic data is the emerges of G-quadruplexes. What are they? Because codon optimization increases the GC content of synthetic mRNAs, there can be an enrichment of G-quartets which potentially form G-quadruplex structures.
24/
I will stop here. #COptiGate will continue tomorrow.
Hopefully it would allow people to catch up, as I know many never even heard about Codon Optimization before.
Tomorrow there will be much more…
Please use the "Show replies" if you don't see anything…
Thanks,
Ehden
I will stop here. #COptiGate will continue tomorrow.
Hopefully it would allow people to catch up, as I know many never even heard about Codon Optimization before.
Tomorrow there will be much more…
Please use the "Show replies" if you don't see anything…
Thanks,
Ehden
25/
#COptiGate, 2022 Xmas Edition - PART 2!
Thanks for your comments and your DM!
I understand that for a some this topic of "Codon Optimization" might seems a bit confusing.
This part will start by (hopefully) clarifying things to those who feel slightly lost…
#COptiGate, 2022 Xmas Edition - PART 2!
Thanks for your comments and your DM!
I understand that for a some this topic of "Codon Optimization" might seems a bit confusing.
This part will start by (hopefully) clarifying things to those who feel slightly lost…
26/
Let's start with the basic building blocks of genetic code: the 4 nucleotide letters – A, C, G, & T/U. In the COVID19 shots, the manufacturers has used a modified uridine (N1-methylpseudouridine) to replace uridine (U) which appears in the original spike protein.
#COptiGate
Let's start with the basic building blocks of genetic code: the 4 nucleotide letters – A, C, G, & T/U. In the COVID19 shots, the manufacturers has used a modified uridine (N1-methylpseudouridine) to replace uridine (U) which appears in the original spike protein.
#COptiGate
27/
Remember that a codon are 3 letters, right? This means 64 combinations (4*4*4).
However, there is something really interesting: a mRNA with CGA codon and a CGG codon will both will result in adding an Arginine nucleotide to the protein it manufacture. Why?
#COptiGate
Remember that a codon are 3 letters, right? This means 64 combinations (4*4*4).
However, there is something really interesting: a mRNA with CGA codon and a CGG codon will both will result in adding an Arginine nucleotide to the protein it manufacture. Why?
#COptiGate
28/
During the process of translation, ribosomes rely on tRNA (Transfer RNA), located in the cell plasma w/cloverleaf structure, to bring the right amino acid element to add to the ribosomes. The tRNA contains a 3-nucleotide codon that anticodon (inverse match) of the mRNA code.
During the process of translation, ribosomes rely on tRNA (Transfer RNA), located in the cell plasma w/cloverleaf structure, to bring the right amino acid element to add to the ribosomes. The tRNA contains a 3-nucleotide codon that anticodon (inverse match) of the mRNA code.
29/
Different species and even different cell types (lungs, shoulder muscles etc.) have different availability of different tRNA, therefore a successful human respiratory virus will be evolutionary optimized, in terms of its code to humans and to the human lung cells.
#COptiGate
Different species and even different cell types (lungs, shoulder muscles etc.) have different availability of different tRNA, therefore a successful human respiratory virus will be evolutionary optimized, in terms of its code to humans and to the human lung cells.
#COptiGate
30/
Since the production of the protein in the ribosome is dependant on the availability of tRNA, if you change the codon to a synonymous codon that has a higher probability of matching the available tRNA in the cell, it should improve the throughput of your product.
#COptiGate
Since the production of the protein in the ribosome is dependant on the availability of tRNA, if you change the codon to a synonymous codon that has a higher probability of matching the available tRNA in the cell, it should improve the throughput of your product.
#COptiGate
31/
This brings us to the next quick overview - the 3-D structure of the protein, which seems to confuse a lot of people.
There are FOUR levels in describing a protein structure, or four levels of organization:
Primary.
Secondary.
Tertiary.
Quaternary.
#COptiGate
This brings us to the next quick overview - the 3-D structure of the protein, which seems to confuse a lot of people.
There are FOUR levels in describing a protein structure, or four levels of organization:
Primary.
Secondary.
Tertiary.
Quaternary.
#COptiGate
32/
Primary (1D): the amino acid sequence. "formula".
Secondary (2D): amino acids linked by peptide bonds (oxygen attached to carbon, nitrogen attached to hydrogen). Oxygen & hydrogen can bond. Interactions of adjacent amino acids can form folding: α-helices and β-plated sheets.
Primary (1D): the amino acid sequence. "formula".
Secondary (2D): amino acids linked by peptide bonds (oxygen attached to carbon, nitrogen attached to hydrogen). Oxygen & hydrogen can bond. Interactions of adjacent amino acids can form folding: α-helices and β-plated sheets.
33/
Tertiary (3D): an attraction between α-helices and β-plated causes the protein to fold.
Quaternary (4D): multiple amino acid chains connect together.
Tertiary (3D): an attraction between α-helices and β-plated causes the protein to fold.
Quaternary (4D): multiple amino acid chains connect together.
34/
An adverse result of low tRNA is ribosomal pausing, which in the case of the COVID19 mRNA "vaccines" means that the spike protein creation will be paused significantly enough to impact proper spike protein folding, which, as I've mentioned before, is not good.
#COptiGate
An adverse result of low tRNA is ribosomal pausing, which in the case of the COVID19 mRNA "vaccines" means that the spike protein creation will be paused significantly enough to impact proper spike protein folding, which, as I've mentioned before, is not good.
#COptiGate
35/
I hope that now, when you look at this image of the "three different Spike Protein Sequences (Moderna (left), Pfizer (middle), SARs-CoV-2(right)) analyzed with RNAfold" I've mentioned above, you can understand there might be structure differences.
I hope that now, when you look at this image of the "three different Spike Protein Sequences (Moderna (left), Pfizer (middle), SARs-CoV-2(right)) analyzed with RNAfold" I've mentioned above, you can understand there might be structure differences.
https://twitter.com/eh_den/status/1606445001243873281
36/
As the researchers have written, "Not only are the secondary structures of the mRNA noticeably different, of note, is the increased number of quadruplex G formations in the codon optimized mRNA vaccines".
If the secondary structures are different, so does the Tertiary (3D)!
As the researchers have written, "Not only are the secondary structures of the mRNA noticeably different, of note, is the increased number of quadruplex G formations in the codon optimized mRNA vaccines".
If the secondary structures are different, so does the Tertiary (3D)!
37/
I've posted a thread last year on the topic, entitled "REVERSE ENGINEERING: WHAT DO WE KNOW ABOUT THE GENETIC CODE WITHIN THE PFIZER VACCINE?", and in it I looked at an analysis done on the #Pfizer and #Moderna genetic code.
#COptiGate
I've posted a thread last year on the topic, entitled "REVERSE ENGINEERING: WHAT DO WE KNOW ABOUT THE GENETIC CODE WITHIN THE PFIZER VACCINE?", and in it I looked at an analysis done on the #Pfizer and #Moderna genetic code.
#COptiGate
https://twitter.com/eh_den/status/1431674294606651393
38/
In the analysis, performed by @XuhuaX who reviewed the genetic sequence used by #Prizer and #Moderna, he stated that:
"THE CODON OPTIMIZATION … SUFFERS FROM LACK OF CONSIDERATION FOR TRANSLATION ACCURACY".
They were focused on throughput!
#COptiGate
In the analysis, performed by @XuhuaX who reviewed the genetic sequence used by #Prizer and #Moderna, he stated that:
"THE CODON OPTIMIZATION … SUFFERS FROM LACK OF CONSIDERATION FOR TRANSLATION ACCURACY".
They were focused on throughput!
#COptiGate
https://twitter.com/eh_den/status/1431780790208172035
39/
From the same review:
"IT IS IMPORTANT FOR VACCINE mRNA TO BE TRANSLATED ACCURATELY BECAUSE MISINCORPORATION OF THE WRONG AMINO ACIDS WOULD CONFUSE OUR IMMUNE SYSTEM IN TARGET RECOGNITION".
Mis-incorporation can also cause prion proteins.
#COptiGate
From the same review:
"IT IS IMPORTANT FOR VACCINE mRNA TO BE TRANSLATED ACCURATELY BECAUSE MISINCORPORATION OF THE WRONG AMINO ACIDS WOULD CONFUSE OUR IMMUNE SYSTEM IN TARGET RECOGNITION".
Mis-incorporation can also cause prion proteins.
#COptiGate
https://twitter.com/eh_den/status/1431780808583487492
40/
As you can see, the regulators (here the #FDA) has never asked manufacturers about their codon optimization decisions. #Pfizer and #Moderna mRNA products and the health implication of their codon optimization were not challenged because regulators have no process to do so!
As you can see, the regulators (here the #FDA) has never asked manufacturers about their codon optimization decisions. #Pfizer and #Moderna mRNA products and the health implication of their codon optimization were not challenged because regulators have no process to do so!
41/
END OF PART 2!
PART 3 will cover research published since my #coptigate publications last year.
I leave you with a question:
How can the UK go into partnership with #Moderna who depend on codon optimization while having no process in place to assure its use is safe?
💖
Ehden
END OF PART 2!
PART 3 will cover research published since my #coptigate publications last year.
I leave you with a question:
How can the UK go into partnership with #Moderna who depend on codon optimization while having no process in place to assure its use is safe?
💖
Ehden
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