As the year ends, it's time once again to discuss some of the best clinical papers in the 🦴 #bone field in 2022!
A long 🧵
@Sandroppa @ECTS_science @larsfolkestad
A long 🧵
@Sandroppa @ECTS_science @larsfolkestad
Nr. 1: Supplemental #VitaminD and Incident #Fractures in Midlife and Older Adults @NEJM
No effect in the VITAL trial although confidence intervals do not exclude meaningful reduction in patients on osteoporosis meds or with fracture history
nejm.org/doi/full/10.10…
No effect in the VITAL trial although confidence intervals do not exclude meaningful reduction in patients on osteoporosis meds or with fracture history
nejm.org/doi/full/10.10…
#VitaminD Deficiency Increases Mortality Risk in the UK Biobank
A Nonlinear Mendelian Randomization Study
Risk increased steeply < 50 nmol/L and was greater with genetic than phenotypic vitamin D deficiency
@AnnalsofIM
acpjournals.org/doi/10.7326/M2…
A Nonlinear Mendelian Randomization Study
Risk increased steeply < 50 nmol/L and was greater with genetic than phenotypic vitamin D deficiency
@AnnalsofIM
acpjournals.org/doi/10.7326/M2…
The effect of #calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials @eLife
Significant effect on peak bone mass accretion at whole body and femoral neck, particularly in those 20-35yo
elifesciences.org/articles/79002
Significant effect on peak bone mass accretion at whole body and femoral neck, particularly in those 20-35yo
elifesciences.org/articles/79002
Calcium #Citrate Versus Calcium Carbonate in the Management of Chronic #Hypoparathyroidism: A Randomized, Double-Blind, Crossover Clinical Trial
@The_JBMR
Lower oxaluria and less constipation with calcium citrate in post-surgical hypoparathyroidism
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
@The_JBMR
Lower oxaluria and less constipation with calcium citrate in post-surgical hypoparathyroidism
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
Mortality and Morbidity in Mild Primary Hyperparathyroidism: Results From a 10-Year Prospective Randomized Controlled Trial of Parathyroidectomy Versus Observation
Parathyroidectomy does not appear to reduce morbidity or mortality in mild PHPT
acpjournals.org/doi/abs/10.732…
Parathyroidectomy does not appear to reduce morbidity or mortality in mild PHPT
acpjournals.org/doi/abs/10.732…
#Pregnancy #VitaminD Supplementation and Childhood Bone Mass at Age 4 Years: Findings From the Maternal Vitamin D Osteoporosis Study (MAVIDOS) Randomized Controlled Trial
@DrBethCurtis18 @ProfNickHarvey @JBMRPlus
sustained beneficial effect
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
@DrBethCurtis18 @ProfNickHarvey @JBMRPlus
sustained beneficial effect
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
Effect of active #vitaminD treatment on development of type 2 diabetes: DPVD randomised controlled trial in Japanese population
eldecalcitol lowered development of diabetes, particularly in those with lower levels of basal insulin secretion
bmj.com/content/377/bm…
eldecalcitol lowered development of diabetes, particularly in those with lower levels of basal insulin secretion
bmj.com/content/377/bm…
#VitaminD supplementation and #exercise for improving physical function, body composition & metabolic health in overweight or obese older adults with vitamin D deficiency: a pilot double-blind RCT
@DavidScottPhD @PeterEbeling2 @Sandroppa @DrAyseZ
link.springer.com/article/10.100…
@DavidScottPhD @PeterEbeling2 @Sandroppa @DrAyseZ
link.springer.com/article/10.100…
Which brings us from #vitaminD to our second topic: #exercise!
Exercise Reduces the Number of Overall and Major Osteoporotic #Fractures in Adults. Does Supervision Make a Difference? Systematic Review and Meta-Analysis @The_JBMR
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
Exercise Reduces the Number of Overall and Major Osteoporotic #Fractures in Adults. Does Supervision Make a Difference? Systematic Review and Meta-Analysis @The_JBMR
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
Bone-loading exercises versus #risedronate for the prevention of osteoporosis in postmenopausal women with low bone mass: a randomized controlled trial
...main effect of risedronate
link.springer.com/article/10.100…
...main effect of risedronate
link.springer.com/article/10.100…
High-Intensity Exercise and Geometric Indices of #Hip Bone Strength in Postmenopausal Women on or off Bone Medication: The MEDEX-OP Randomised Controlled Trial
@BelindaRBeck
Effect of medication, particularly when combined with exercise
link.springer.com/article/10.100…
@BelindaRBeck
Effect of medication, particularly when combined with exercise
link.springer.com/article/10.100…
...which brings us to: HRpQCT!
Hip Fractures in Older Adults Are Associated With Low Density Bone Phenotype and Deterioration of Bone Microarchitecture
@d_whittier @The_JBMR
...should we define osteoporosis as high void space instead of low T-scores?
asbmr.onlinelibrary.wiley.com/doi/10.1002/jb…
Hip Fractures in Older Adults Are Associated With Low Density Bone Phenotype and Deterioration of Bone Microarchitecture
@d_whittier @The_JBMR
...should we define osteoporosis as high void space instead of low T-scores?
asbmr.onlinelibrary.wiley.com/doi/10.1002/jb…
Distribution of Fracture Sites in Postmenopausal Overweight and Obese Women: The FRISBEE Study
...are ankle fractures osteoporotic or diabetic/obesity fractures? I think the latter
link.springer.com/article/10.100…
...are ankle fractures osteoporotic or diabetic/obesity fractures? I think the latter
link.springer.com/article/10.100…
...moving on to therapeutics!
Efficacy of #ZoledronicAcid in the Treatment of Nonmalignant Painful Bone Marrow Lesions: A Triple-Blind, Randomized, Placebo-Controlled Phase III Clinical Trial (ZoMARS) @The_JBMR
treatment for painful bone marrow lesions
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
Efficacy of #ZoledronicAcid in the Treatment of Nonmalignant Painful Bone Marrow Lesions: A Triple-Blind, Randomized, Placebo-Controlled Phase III Clinical Trial (ZoMARS) @The_JBMR
treatment for painful bone marrow lesions
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
#Zoledronate Reduces Height Loss Independently of #Vertebral Fracture Occurrence in a Randomized Trial in Osteopenic Older Women
Reid et al., more ZOLepenia trial findings
...prevents vertebral fractures and height loss independently
asbmr.onlinelibrary.wiley.com/doi/abs/10.100…
Reid et al., more ZOLepenia trial findings
...prevents vertebral fractures and height loss independently
asbmr.onlinelibrary.wiley.com/doi/abs/10.100…
Renal safety of zoledronic acid for osteoporosis in adults 75 years and older
@iofbonehealth
No clinically relevant nephrotoxicity => stop using Cockroft-Gault equation?
link.springer.com/article/10.100…
@iofbonehealth
No clinically relevant nephrotoxicity => stop using Cockroft-Gault equation?
link.springer.com/article/10.100…
Potential Adverse Effect of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) on Bisphosphonate Efficacy: An Exploratory Post Hoc Analysis From a Randomized Controlled Trial of Clodronate
@mccloskey_e
Efficacy of clodronate negated in those receiving NSAIDs
asbmr.onlinelibrary.wiley.com/doi/10.1002/jb…
@mccloskey_e
Efficacy of clodronate negated in those receiving NSAIDs
asbmr.onlinelibrary.wiley.com/doi/10.1002/jb…
Next up: #denosumab!
Multiple Vertebral Fractures After Denosumab Discontinuation: FREEDOM and FREEDOM Extension Trials Additional Post Hoc Analyses @The_JBMR
Dmab associated with multiple VFx, esp. after longer duration @BotcentrumLUMC
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
Multiple Vertebral Fractures After Denosumab Discontinuation: FREEDOM and FREEDOM Extension Trials Additional Post Hoc Analyses @The_JBMR
Dmab associated with multiple VFx, esp. after longer duration @BotcentrumLUMC
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
Discontinuation of denosumab in men with prostate cancer
...findings in post-menopausal women extended to castrated men
@iofbonehealth
link.springer.com/article/10.100…
...findings in post-menopausal women extended to castrated men
@iofbonehealth
link.springer.com/article/10.100…
Diabetes Mellitus and the Benefit of Antiresorptive Therapy on Fracture Risk
@EastellR @MaryBouxsein @The_JBMR
Denosumab effect on non-vertebral fractures and total hip BMD attenuated in T2D
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
@EastellR @MaryBouxsein @The_JBMR
Denosumab effect on non-vertebral fractures and total hip BMD attenuated in T2D
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
Asian Ethnicity and Femoral Geometry in #Atypical Femur Fractures: Independent or Interdependent Risk Factors? @JBMRPlus
Asian ethnicity strong independent risk factor for AFF, unaccounted for by ethno-specific differences in proximal femoral geometry
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
Asian ethnicity strong independent risk factor for AFF, unaccounted for by ethno-specific differences in proximal femoral geometry
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
Factors affecting healing and progression of conservatively treated incomplete #atypical femoral fractures: retrospective observational study
...bisphosphonates, dreaded black line and symptoms predicted progression
link.springer.com/article/10.100…
...bisphosphonates, dreaded black line and symptoms predicted progression
link.springer.com/article/10.100…
Osteonecrosis of the Jaw and Antiresorptive Agents in Benign and Malignant Diseases: A Critical Review Organized by the @ECTS_soc
@AcademyEcts @EndoSocJournals @a_anastasilakis
academic.oup.com/jcem/article/1…
@AcademyEcts @EndoSocJournals @a_anastasilakis
academic.oup.com/jcem/article/1…
Next topic: romo!
Modeling-Based Bone Formation After 2 Months of #Romosozumab Treatment: Results From the FRAME Clinical Trial
@The_JBMR
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
[ thread continues in next post ]
Modeling-Based Bone Formation After 2 Months of #Romosozumab Treatment: Results From the FRAME Clinical Trial
@The_JBMR
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
[ thread continues in next post ]
Effects of prior osteoporosis treatment on the treatment response of #romosozumab in patients with postmenopausal osteoporosis
...best in treatment-naïve; less in bisphosphonate/teriparatide exposed; worst after dmab discontinuation!
link.springer.com/article/10.100…
...best in treatment-naïve; less in bisphosphonate/teriparatide exposed; worst after dmab discontinuation!
link.springer.com/article/10.100…
Sclerostin Protects Against Vascular Calcification Development in Mice @The_JBMR
...increased vascular calficiation in two induced CKD models with genetic or pharmacological sclerostin inhibition
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
...increased vascular calficiation in two induced CKD models with genetic or pharmacological sclerostin inhibition
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
Efficacy and Safety of #Romosozumab Among Postmenopausal Women With Osteoporosis and Mild-to-Moderate Chronic Kidney Disease
...reassuring safety, while efficacy in other small series in advanced CKD @AngelaMCheung
asbmr.onlinelibrary.wiley.com/doi/10.1002/jb…
...reassuring safety, while efficacy in other small series in advanced CKD @AngelaMCheung
asbmr.onlinelibrary.wiley.com/doi/10.1002/jb…
A review in @TheLancet entitled:
"Drug therapy for osteoporosis in older adults"
Reid & Billington
thelancet.com/article/S0140-…
"Drug therapy for osteoporosis in older adults"
Reid & Billington
thelancet.com/article/S0140-…
...but how to close the treatment gap in osteoporsis?
FLS!
Decreased Mortality and Subsequent Fracture Risk in Patients With a Major and Hip Fracture After the Introduction of a #FractureLiaisonService: A 3-Year Follow-Up Survey
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
FLS!
Decreased Mortality and Subsequent Fracture Risk in Patients With a Major and Hip Fracture After the Introduction of a #FractureLiaisonService: A 3-Year Follow-Up Survey
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
Osteoporosis in Europe: a compendium of country-specific reports
@iofbonehealth @ProfNickHarvey @mccloskey_e
SCOPE update 2022
link.springer.com/article/10.100…
@iofbonehealth @ProfNickHarvey @mccloskey_e
SCOPE update 2022
link.springer.com/article/10.100…
More epidemiology and healthcare burden assessment:
The Economic Burden of Severe Osteoporotic Fractures in the French Healthcare Database: The FRACTOS Study
@Julienpaccoujp7
asbmr.onlinelibrary.wiley.com/doi/10.1002/jb…
The Economic Burden of Severe Osteoporotic Fractures in the French Healthcare Database: The FRACTOS Study
@Julienpaccoujp7
asbmr.onlinelibrary.wiley.com/doi/10.1002/jb…
Costs of patient management over 18 months following a hip, clinical vertebral, distal forearm, or proximal humerus fragility fracture in France—results from the ICUROS study
@iofbonehealth
link.springer.com/article/10.100…
@iofbonehealth
link.springer.com/article/10.100…
Target Values and Daytime Variation of Bone #Turnover Markers in Monitoring Osteoporosis Treatment After Fractures
...study of great practical value for clinical interpretation of BTMs
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
...study of great practical value for clinical interpretation of BTMs
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
...moving on to rare bone disease:
Bone Mass, Density, Geometry, and Stress–Strain Index in Adults With #OsteogenesisImperfecta Type I and Their Associations With Physical Activity and Muscle Function Parameters
@The_JBMR @OIFE_OI
asbmr.onlinelibrary.wiley.com/doi/abs/10.100…
Bone Mass, Density, Geometry, and Stress–Strain Index in Adults With #OsteogenesisImperfecta Type I and Their Associations With Physical Activity and Muscle Function Parameters
@The_JBMR @OIFE_OI
asbmr.onlinelibrary.wiley.com/doi/abs/10.100…
Targeting TGF-β for treatment of osteogenesis imperfecta
@jclinicalinvest
...from patient samples to clinical trials with fresolimumab, particularly in type IV OI
jci.org/articles/view/…
@jclinicalinvest
...from patient samples to clinical trials with fresolimumab, particularly in type IV OI
jci.org/articles/view/…
Identification of ENPP1 Haploinsufficiency in Patients With Diffuse Idiopathic Skeletal Hyperostosis and Early-Onset Osteoporosis
...provocative findings: ENPP1 haploinsufficiency as a DISH mimic with osteoporosis and hypophosphatemia @TissueHomandDis
asbmr.onlinelibrary.wiley.com/doi/abs/10.100…
...provocative findings: ENPP1 haploinsufficiency as a DISH mimic with osteoporosis and hypophosphatemia @TissueHomandDis
asbmr.onlinelibrary.wiley.com/doi/abs/10.100…
Phase 2 results from palovarotene in FOP @The_JBMR
Palovarotene for Fibrodysplasia Ossificans Progressiva (FOP): Results of a Randomized, Placebo-Controlled, Double-Blind Phase 2 Trial
@sfeirjad
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
Palovarotene for Fibrodysplasia Ossificans Progressiva (FOP): Results of a Randomized, Placebo-Controlled, Double-Blind Phase 2 Trial
@sfeirjad
asbmr.onlinelibrary.wiley.com/doi/full/10.10…
Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1
...surprising twist for anti-ACVR1 antibodies! Difficult path for development in FOP... @Osteoporosis_NL
jci.org/articles/view/…
...surprising twist for anti-ACVR1 antibodies! Difficult path for development in FOP... @Osteoporosis_NL
jci.org/articles/view/…
And finally... I'm gonna be talking a LOT about prunes with my patients these days, thanks to these authors
...small effect on preservation of hip BMD compared to loss in controls with moderate dose of prunes (poor compliance with high dose)
academic.oup.com/ajcn/article-a…
...small effect on preservation of hip BMD compared to loss in controls with moderate dose of prunes (poor compliance with high dose)
academic.oup.com/ajcn/article-a…
P.S.: In case you missed out, here was last year's overview 👇
https://twitter.com/MichalLaurent11/status/1473403984048177157?s=20&t=c1729blM46UXV1CxGj0z9A
Join us at the 2023 Belgian Bone Club clinical update symposium to find out more!
Saturday January 21st, Brussels and online
@olibruyere @etiennecavalier
bbcbonehealth.org/clinical-updat…
Saturday January 21st, Brussels and online
@olibruyere @etiennecavalier
bbcbonehealth.org/clinical-updat…
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