Raj Rajnarayanan Profile picture
Jan 3, 2023 18 tweets 15 min read Read on X
#COVID19 #VariantDashboard - #UnitedStates

Holiday season - Low seq count this 15day period!

TOP lineages (#15DAYTRENDS):

35.7% XBB.1.5
13.4% BQ.1.1
8.5% BQ.1
4.1% XBB.1
2.8% BQ.1.1.4
2.6% BQ.1.1.3

Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 01/02/2023

1/n
Sequence count by US State

New York has submitted a HUGE SHARE of sequences with specimen collection dates in the last 15 days.

2/n
Granular details -#VariantDashboard #USA #15DayTrends

3/n
.@CDCgov updated variant proportions estimates on 12/30/2022 (updated every Friday)

Several BQ* are circulating at >1% especially BQ.1.22 is a good candidate to be included in CDC's Nowcast estimates next week!



4/n
#Global #VariantSoup 01/02/2023

Top lineages with at least 5 key convergent #Spike mutations (#30DayTrends):

BQ.1.1 (24.09%)
BQ.1 (8.90%)
BQ.1.22 (4.12%)
XBB.1 (4.04%)
CH.1.1 (2.84%)👀
XBB.1.5 (2.84%)👀
BN.1.3 (2.27%)
BQ.1.2 (2.21%)
BQ.1.1.4 (2.00%)
BQ.1.1.20 (1.71%)

5/n
Predicted Immune Escape and ACE2 binding of top lineages in USA (relative to BA.2)

Bivalent boosters (OG/Omicron.BA.5) will potentially protect the boosted from getting severe disease/hospitalizations.

Please get #boosted ASAP!

public.tableau.com/app/profile/ra…

6/n
#Hospital #Capacity - (by State/Division)

All hospitalizations not just COVID-19

public.tableau.com/app/profile/ra…

7/n
#COVID19 #Hospitalizations in the #UnitedStates

Please get #boosted (especially > 50 yr old and immune compromised) and #MaskUP!

Hospital Tracker (by States, by age group): public.tableau.com/app/profile/ra…

8/n
Status of the latest #COVID19 Wave in #NewYork #BellwetherState

XBB.1.5 is the dominant #SARSCoV2 lineage in NY

Top Lineages (#15DAYTrends):

XBB.1.5 (55.6%)👀🚀
BQ.1.1 (9.6%)⬇️
XBB.1 (6.1%)
BQ.1 (5.5%)
BQ.1.1.4 (2.2%)
BQ.1.1.3 (1.6%)
XBB.2 (1.6%)
..
CH.1.1 (1%)

9/n
Rise of highly immune evasive XBB* family of lineages especially XBB.1.5 (Key mutation: Spike F486P) in NY is concerning

fortune.com/well/2022/11/0…

10/n
BQ* Hotspots - #USA #15DayTrends

11/n
Recombinant lineage hotspots - #USA #15DayTrends

12/n
Adding CH.1.1* (BA.2.75's sub-lineage) to the watch list

Lineage that's surging in the #UnitedKingdom now. CH.1.1* is already at 1% in NY.

Will the one to watch after XBB.1.5!

13/n
Tracking the current #COVID19 wave, variant soup and #Hospitalizations 👀 in #Massachusetts

No sequences with sample collection dates in the last 15 days.

14/n
Tracking the current #COVID19 wave, variant soup and #Hospitalizations 👀 in #Connecticut

XBB.1.5 is the top circulating lineage in CT

16/n
Tracking the current #COVID19 wave, variant soup and #Hospitalizations in #NewJersey

Low sequence count

17/n
Tracking the current #COVID19 wave, variant soup and #Hospitalizations in #Virginia

XBB is the top circulating lineage in VA

[low sequence count]

18/n

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More from @RajlabN

Oct 20
Tracking #SARSCoV2 #Lineages - Globally |10/19/24

Top lineages -#30DayTrends #G30

KP.3.1.1 (41.9%)
XEC (10.5%)👀
KP.2.3 (3.1%)
MC.13 (3.1%)
MC.16 (2.6%)
MC.1 (2.5%)
KP.3.3 (2.3%)
LB.1.3.1 (1.9%)
MC.10 (1.7%)
MC.11 (1.4%)
XEC.2 (1.3%)👀



1/n public.tableau.com/app/profile/ra…Image
Granular details #Global #30DayTrends

KP.3.1.1* is still the top circulating group of lineages in the world.

This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 09/19/2024 (11,851sequences)

2/n Image
@GISAID Thanks to all the countries that are supporting #SARSCoV2 testing and rapidly submitting sequences to @GISAID

Top submitters #Canada #USA #France #UK #Netherlands #Sweden #Spain #Japan #Italy
#Denmark #Australia #Ireland #Singapore
#China #NewZealand #Slovenia #Germany

3/n Image
Read 4 tweets
Sep 27
#SARSCoV2 #VariantProportions - #USA |09/27/24

@CDCgov #Nowcast 2-Week estimates

KP.3.1.1 (JN.1.11.1.3.1.1) is still the top circulating lineage in the USA

🚨XEC makes an entry @ 5.7%



1/n covid.cdc.gov/covid-data-tra…
Image
Reliable nowcast estimates are available only for HHS regions 2, 3, 4, 5, 7 and 9

Other regions did not sequence enough

2/n Image
KP.3.1.1* group of lineages

In the @CDCgov nowcast chart....
KP.3.1.1* is not further separated in to MC.1-MC.16 sub-lineages

3/n Image
Read 6 tweets
Sep 8
Tracking #SARSCoV2 #Lineages - Globally |09/07/24

Top lineages -#30DayTrends

KP.3.1.1 (37.1%)
KP.2.3 (9%)
KP.3.3 (5.7%)
KP.3.1 (2.9%)
XDV.1 (2.9%)
KP.1.1.3 (2.7%)
LB.1 (2.3%)
LB.1.3 (2.1%)
KP.2.2 (2%)
---
XEC (1.4%)👀

Track #G30 :

1/n public.tableau.com/app/profile/ra…
Image
Granular details #Global #30DayTrends

KP.3.1.1* is still the top circulating group of lineages in the world.

This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 08/08/2024 (12,884 sequences)

2/n Image
@GISAID Thanks to all the countries that are supporting #SARSCoV2 testing and rapidly submitting sequences to @GISAID

Top submitters #USA #Canada #UK #Sweden #Japan
#China #Spain #Australia #Germany #Denmark #SouthKorea #France #Singapore #NewZealand #Ireland #Italy #Netherlands Image
Read 16 tweets
Sep 1
What the XEC!

Recombinant #SARSCoV2 lineage #XEC (recombinant of KS.1.1/KP.3.3) has the potential to outcompete other circulating lineages in #USA (and other countries)

More data is needed to provide a reliable growth advantage estimates
Image
#VariantHunters are closely monitoring XEC.1 with signature mutations Spike K182R & ORF1a:L4182F
XEC.1 was proposed by #VariantHunter @siamosolocani

github.com/sars-cov-2-var…
Read 5 tweets
Aug 25
Tracking #SARSCoV2 #Lineages - Globally |08/25/24

Top lineages -#30DayTrends

KP.3.1.1 (30.1%)👀
KP.2.3 (11%)
KP.3.3 (7.1%)
KP.3.1 (4.2%)
LB.1.7 (2.7%)
KP.2 (2.5%)
LB.1 (2.5%)
KP.1.1.3 (2.5%)
KP.2.2 (2.2%)
---
XEC (0.4%)

Track #G30 :

1/n public.tableau.com/app/profile/ra…
Image
Granular details #Global #30DayTrends

KP.3.1.1* is the top circulating group of lineages in the world. This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 07/25/2024 (14,688 sequences)

2/n Image
@GISAID Thanks to all the countries that are still supporting #SARSCoV2 testing and rapidly submitting sequences to @GISAID

Top submitters: #USA #Canada #UK #Japan #Spain
#Sweden #Netherlands #SouthKorea #Denmark #Israel #Ireland #Singapore #Australia #China #Germany #Italy #France Image
Read 17 tweets
Aug 11
Tracking #SARSCoV2 #Lineages - Globally |08/10/24

Top lineages -#30DayTrends

KP.3.1.1 (24.2%)👀
KP.2.3 (9.5%)
KP.3.3 (8.4%)
KP.3.1 (5.9%)
LB.1 (2.5%)
KP.2.2 (2.4%)
KP.2 (2.4%)
KP.3 (2.3%)
LB.1.7 (2.3%)
KP.3.2.3 (2.2%)

Track #G30 :

1/n public.tableau.com/app/profile/ra…
Image
Granular details #Global #30DayTrends

KP.3.1.1 is the top circulating lineage in the world. This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 07/11/2024 (15,325 sequences)

2/n Image
@GISAID Thanks to all the countries that are still supporting #SARSCoV2 testing and rapidly submitting sequences to @GISAID

Top submitters: #USA #Canada #UK #Japan #Spain
#France #China #Netherlands #Israel #Ireland
#Australia #Singapore #Denmark #Italy #Sweden #Germany #Guatemala Image
Read 21 tweets

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