Raj Rajnarayanan Profile picture
Jan 5, 2023 21 tweets 18 min read Read on X
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (#15DAYTRENDS):

18.9% XBB.1.5
14.5% BQ.1.1
9.6% BQ.1
6.6% BQ.1.22
3.2% XBB.1
2.4% BQ.1.1.4
2.3% BQ.1.3
2.1% BQ.1.12
2.0% BQ.1.1.3

Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 01/04/2023

1/n
Sequence count by US State

New York, California, North Carolina, Washington, Virginia and Florida have submitted a large share of sequences with specimen collection dates in the last 15 days.

2/n
Granular details -#VariantDashboard #USA #15DayTrends

3/n
.@CDCgov updated variant proportions estimates on 12/30/2022 (updated every Friday)

Several BQ* are circulating at >1% especially BQ.1.1.3/4, BQ.1.22 are good candidates to be included in CDC's Nowcast estimates next week!



4/n
#Global #VariantSoup 01/04/2023

Top lineages with at least 5 key convergent #Spike mutations (#30DayTrends):

BQ.1.1 (24.36%)
BQ.1 (8.59%)
BQ.1.22 (4.10%)
XBB.1 (3.95%)
XBB.1.5 (3.04%)👀
CH.1.1 (2.95%)👀
BN.1.3 (2.24%)
BQ.1.2 (2.14%)
BQ.1.1.4 (1.99%)
BQ.1.1.20 (1.79%)

5/n
Predicted Immune Escape and ACE2 binding of top lineages in USA (relative to BA.2)

Bivalent boosters (OG/Omicron.BA.5) will potentially protect the boosted from getting severe disease/hospitalizations.

Please get #boosted ASAP!

public.tableau.com/app/profile/ra…

6/n
#Hospital #Capacity - (by State/Division)

All hospitalizations not just COVID-19

public.tableau.com/app/profile/ra…

7/n
#COVID19 #Hospitalizations in the #UnitedStates

Please get #boosted (especially > 50 yr old and immune compromised) and #MaskUP!

Hospital Tracker (by States, by age group): public.tableau.com/app/profile/ra…

8/n
Status of the latest #COVID19 Wave in #NewYork #BellwetherState

XBB.1.5 is the dominant #SARSCoV2 lineage in NY

Top Lineages (#15DAYTrends):

XBB.1.5 (53.4%)👀🚀
BQ.1.1 (10.1%)
XBB.1 (6.2%)
BQ.1 (4.1%)
BQ.1.1.4 (2.6%)
BQ.1.3 (2.3%)
BQ.1.1.3 (2.1%)
..
CH.1.1 (1%)

9/n
Rise of highly immune evasive XBB* family of lineages especially XBB.1.5 (Key mutation: Spike F486P) in NY is concerning

fortune.com/well/2022/11/0…

10/n
BQ* Hotspots - #USA #15DayTrends

11/n
Adding BN* & CH.1.1* (BA.2.75's sub-lineages) to the watch list

12/n
Recombinant lineage XBB.1.5* hotspots - #USA #15DayTrends

13/n
Why the new COVID variant XBB.1.5 is taking over the U.S. so quickly

14/n

salon.com/2023/01/04/why…
Tracking the current #COVID19 wave, variant soup and #Hospitalizations 👀 in #Massachusetts

3 sequences with sample collection dates in the last 15 days (1 each of CK.1, BQ.1.13 & XBB.1.5).

15/n
Tracking the current #COVID19 wave, variant soup and #Hospitalizations 👀 in #Connecticut

XBB.1.5 is the top circulating lineage in CT

16/n
Tracking the current #COVID19 wave, variant soup and #Hospitalizations in #NewJersey

XBB.1.5 is the top circulating lineage in NJ

17/n
Tracking the current #COVID19 wave, variant soup and #Hospitalizations in #Virginia

BQ.1.1 & XBB.1.5 are the top circulating lineages in VA

[low sequence count]

18/n
Tracking the current #COVID19 wave, variant soup and #Hospitalizations in #Florida

BQ.1.22, XBB.1.5 and BQ.1.1 are the top circulating lineages in FL

[low sequence count]

19/n
Tracking the current #COVID19 wave, variant soup and #Hospitalizations in #California

BQ.1.1, BQ.1, BQ.1.22 and XBB.1.5 are the top circulating lineages in CA

19/n

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More from @RajlabN

Jan 1
#H5N1 #AvianInfluenza updates

New @NEJM case report describing severe human illness caused by highly pathogenic avian influenza A -H5N1 in #BritishColumbia (#Canada) teenager with evidence of potential viral adaptation to humans.



1/n nejm.org/doi/full/10.10…Image
A 13-year-old girl with mild asthma and obesity (BMI >35) presented with conjunctivitis, fever, respiratory distress, and multi-organ complications was hospitalized on 11/7/24, and required intensive care, including ECMO and continuous renal therapy

2/n
RT-PCR confirmed A/H5N1 infection, and the virus was linked to wild birds in British Columbia.

Genetic analysis revealed mutations in the HA protein (E186D, Q222H), associated with increased binding to human airway receptors, facilitating viral entry and replication.

3/n
Read 6 tweets
Dec 22, 2024
#H5N1 #AvianInfluenza updates

Quick analysis of the 7 sequences from NIAID experimental study of #Macaques infected w/ H5N1 2.3.4.4b (B3.13 type)

PB2 mutations: T58A, V109I, V139I, E362G, K389R, D441N, V478I, V495I, M631L, V649I, M676A, E677K

Ref: A/Duck/Guangdong/E1/2012

1/n
HA mutations: L120M, L131Q, T211I, V226A, I526V

Ref: A/Astrakhan/3212_cell/2020

2/n
NA mutations: V67I, D259E, L269M, V321I, S339P

Ref: A/AmericanWigeon/SouthCarolina/22-000345-001/2021

3/n
Read 4 tweets
Oct 20, 2024
Tracking #SARSCoV2 #Lineages - Globally |10/19/24

Top lineages -#30DayTrends #G30

KP.3.1.1 (41.9%)
XEC (10.5%)👀
KP.2.3 (3.1%)
MC.13 (3.1%)
MC.16 (2.6%)
MC.1 (2.5%)
KP.3.3 (2.3%)
LB.1.3.1 (1.9%)
MC.10 (1.7%)
MC.11 (1.4%)
XEC.2 (1.3%)👀



1/n public.tableau.com/app/profile/ra…Image
Granular details #Global #30DayTrends

KP.3.1.1* is still the top circulating group of lineages in the world.

This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 09/19/2024 (11,851sequences)

2/n Image
@GISAID Thanks to all the countries that are supporting #SARSCoV2 testing and rapidly submitting sequences to @GISAID

Top submitters #Canada #USA #France #UK #Netherlands #Sweden #Spain #Japan #Italy
#Denmark #Australia #Ireland #Singapore
#China #NewZealand #Slovenia #Germany

3/n Image
Read 4 tweets
Sep 27, 2024
#SARSCoV2 #VariantProportions - #USA |09/27/24

@CDCgov #Nowcast 2-Week estimates

KP.3.1.1 (JN.1.11.1.3.1.1) is still the top circulating lineage in the USA

🚨XEC makes an entry @ 5.7%



1/n covid.cdc.gov/covid-data-tra…
Image
Reliable nowcast estimates are available only for HHS regions 2, 3, 4, 5, 7 and 9

Other regions did not sequence enough

2/n Image
KP.3.1.1* group of lineages

In the @CDCgov nowcast chart....
KP.3.1.1* is not further separated in to MC.1-MC.16 sub-lineages

3/n Image
Read 6 tweets
Sep 8, 2024
Tracking #SARSCoV2 #Lineages - Globally |09/07/24

Top lineages -#30DayTrends

KP.3.1.1 (37.1%)
KP.2.3 (9%)
KP.3.3 (5.7%)
KP.3.1 (2.9%)
XDV.1 (2.9%)
KP.1.1.3 (2.7%)
LB.1 (2.3%)
LB.1.3 (2.1%)
KP.2.2 (2%)
---
XEC (1.4%)👀

Track #G30 :

1/n public.tableau.com/app/profile/ra…
Image
Granular details #Global #30DayTrends

KP.3.1.1* is still the top circulating group of lineages in the world.

This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 08/08/2024 (12,884 sequences)

2/n Image
@GISAID Thanks to all the countries that are supporting #SARSCoV2 testing and rapidly submitting sequences to @GISAID

Top submitters #USA #Canada #UK #Sweden #Japan
#China #Spain #Australia #Germany #Denmark #SouthKorea #France #Singapore #NewZealand #Ireland #Italy #Netherlands Image
Read 16 tweets
Sep 1, 2024
What the XEC!

Recombinant #SARSCoV2 lineage #XEC (recombinant of KS.1.1/KP.3.3) has the potential to outcompete other circulating lineages in #USA (and other countries)

More data is needed to provide a reliable growth advantage estimates
Image
#VariantHunters are closely monitoring XEC.1 with signature mutations Spike K182R & ORF1a:L4182F
XEC.1 was proposed by #VariantHunter @siamosolocani

github.com/sars-cov-2-var…
Read 5 tweets

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